Research Papers

List of published paper

1:Suzuki, M., Fujimori, H., Wakatsuki, K., Manaka, Y., Asai, H., Hyodo, M., Matsuno, Y., Kusumoto-Matsuo, R., Shiroishi, M., and Yoshioka, K., Genome Destabilization-Associated Phenotypes Arising as a Consequence of Therapeutic Treatment are Suppressed by Olaparib. PLoS ONE, 18 (2023) e0281168. https://doi.org/10.1371/journal.pone.0281168.

2: Matsuno, Y., Kusumoto-Matsuo, R., Asai, H., Manaka, Y., and Yoshioka, K. Echoed Induction of Nucleotide Variants and Chromosomal Structural Variants in Cancer Cells. Scientific Reports, 12 (2022) 20964. https://doi.org/10.1038/s41598-022-25479-6.

3: Yoshioka, K., Kusumoto-Matsuo, R., Matsuno, Y., and Ishiai, M. Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair. Int. J. Mol. Sci., 22 (2021) 12254. https://doi.org/10.3390/ijms222212254.

4: Matsuno, Y., Hyodo, M., Suzuki, M.,Tanaka, Y., Horikoshi, Y.,  Murakami, Y., Torigoe, H., Mano, H., Tashiro, S., and Yoshioka, K. Replication Stress-Associated DSBs Arisen by Ionizing Radiation Risk Genomic Destabilization and the Associated Clonal Evolution. iScience, 24 (2021) 102313. https://doi.org/10.1016/j.isci.2021.102313.(linked at external site)

5: Yoshioka, K. and Matsuno, Y. Genomic Destabilization and its Associated Mutagenesis Increase with Senescence-Associated Phenotype Expression. Cancer Science, 112 (2021) 515–522. DOI: 10.1111/cas.14746.

6: Matsuno, Y., Atsumi, Y., Alauddin, M., Rana, M.M., Fujimori, H., Hyodo, M., Shimizu, A., Ikuta, T., Tani, H., Torigoe, H., Nakatsu, Y., Tsuzuki, T., Komai, M., Shirakawa, H., and Yoshioka, K. Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability. Scientific Reports, 10 (2020) 5388. https://doi.org/10.1038/s41598-020-62292-5.(linked at external site)

7: Fujimori, H., Hyodo, M., Matsuno, Y., Shimizu, A., Minakawa, Y., Atsumi, Y., Nakatsu, Y., Tsuzuki, T., Murakami, Y., and Yoshioka, K. Mismatch Repair Dependence of Replication Stress-Associated DSB Recognition and Repair. Heliyon, 4 (2019) e03057. https://doi.org/10.1016/j.heliyon.2019.e03057.(linked at external site)

8: Yoshioka, K., Matsuno, Y., Hyodo, M., and Fujimori, H. Genomic-destabilization-associated mutagenesis and clonal evolution of cells mutated in tumor-suppressor genes. Cancers 11 (2019) 1643. doi:10.3390/cancers11111643.

9: Matsuno, Y., Atsumi, Y., Shimizu, A., Katayama, K., Fujimori, H., Hyodo, M., Nakatsu, Y., Kaneko, S., Hamamoto, R., Shimamura, T., Miyano, S., Tsuzuki, T., Hanaoka, F., and Yoshioka, K. Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro. Nature Communications, 10 (2019) 3925. doi:10.1038/s41467-019-11760-2.

10: Motegi, A., Masutani, M., Yoshioka, K., and Bessho, T. Aberrations in DNA repair pathways in cancer and therapeutic significances. Seminars in Cancer Biology 58 (2019) 29-46. doi: 10.1016/j.semcancer.2019.02.005.

11: Shimizu, A., Fujimori, H., Minakawa, Y., Matsuno, Y., Hyodo, M., Murakami, Y., and Yoshioka, K. Onset of deaminase APOBEC3B induction in response to DNA double-strand breaks. Biochem. Biophys. Reports 16 (2018) 115-121. https://doi.org/10.1016/j.bbrep.2018.10.010.(linked at external site)

12: Matsuno, Y., Hyodo, M., Fujimori, H., and Yoshioka, K. Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules. Cancers, 10 (2018) 364. doi:10.3390/cancers10100364.

13: Matsuno, Y., Torigoe, H., and Yoshioka, K. Establishment of Cellular Quiescence Together with H2AX Downregulation and Genome Stability Maintenance. J Clin Exp Pathol, 8 (2018) 1000335.

14: Minakawa, Y., Shimizu, A., Matsuno, Y., and Yoshioka, K. Genomic Destabilization Triggered by Replication Stress during Senescence. Cancers, 9 (2017) 159. doi:10.3390/cancers9110159.

15: Minakawa, Y., Atsumi, Y., Shinohara, A., Murakami, Y., Teraoka, H., and Yoshioka, K. Gamma-irradiated quiescent cells repair directly induced double-strand breaks but accumulate persistent double-strand breaks during subsequent DNA replication. Genes Cells, 21 (2016) 789-797. doi:10.1111/gtc.12381.

16: Atsumi, Y., Minakawa, Y., Ono, M., Dobashi, S., Shinohe, K., Shinohara, A., Takeda, S., Takagi, M., Takamatsu, N., Nakagama, H., Teraoka, H., and Yoshioka, K. ATM and SIRT6/SNF2H mediate transient H2AX stabilization when DSBs form by blocking HUWE1 to allow efficient γH2AX foci formation. Cell Reports, 13 (2015) 2728-2740. doi:10.1016/j.celrep.2015.11.054.

17: Yoshioka, K., Atsumi, Y., Nakagama, H., and Teraoka, H. Development of cancer-initiating cells and immortalized cells with genomic instability. World J Stem Cells, 7, (2015) 483-489.

18: Atsumi, Y., Inase, A., Osawa, T., Sugihara, E., Sakasai, R., Fujimori, H., Teraoka, H., Saya, H., Kanno, M., Tashiro, F., Nakagama, H., Masutani, M., and Yoshioka, K. Arf/p53 module, which induces apoptosis, downregulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. J. Biol. Chem., 288 (2013) 13269-13277. doi:10.1074/jbc.M112.402560.

19: Osawa, T., Atsumi, Y., Sugihara, E., Saya, H., Kanno, M., Tashiro, F., Masutani, M., and Yoshioka, K. Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes. Biochem. Biophys. Res. Comm. 432 (2013) 34-39. doi:10.1016/j.bbrc.2013.01.091.

20: Fujimori, H. Shikanai, M., Teraoka, H., Masutani, M., and Yoshioka, K. Induction of Cancerous Stem Cells during Embryonic Stem Cell Differentiation. J. Biol. Chem., 287 (2012) 36777-36791.

21: Yoshioka, K., Atsumi, Y., Fukuda, H., Masutani, M., and Teraoka, H. The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability. Int. J. Mol. Sci. 13, (2012) 6492-6506. doi:10.3390/ijms13056492.

22: Atsumi, Y., Fujimori, H., Fukuda, H., Inase, A., Shinohe, K., Yoshioka, Y., Shikanai, M., Ichijima, Y., Unno, J., Mizutani, S., Tsuchiya, N., Hippo, Y., Nakagama, H., Masutani, M., Teraoka, H., and Yoshioka, K. Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells. PLoS ONE, 6, (2011) e23432. doi:10.1371/journal.pone.0023432.

23: Ichijima, Y., Yoshioka, K., Shinohe, K., Fujimori, H., Yoshioka, Y., Unno, J., Takagi, M., Goto, H., Inagaki, M., Mizutani, S. and Teraoka, H., DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development. PLoS ONE, 5, (2010) e8821. doi:10.1371/journal.pone.0008821.