Yasushi Uemura, DDS, PhD

 

We are aiming to reduce cancer-associated mortality by realizing truly effective next-generation medicines, by establishing broadly applicable immune cell platforms for the selective elimination of cancer cells.

Official title

• Laboratory Chief, Division of Cancer Immunotherapy (Kashiwa)

Areas of research

• Immunology, Cancer Immunotherapy

Keywords

• Immunomodulation
• Cell therapy

Research

• Cancer therapy using regenerated immune cells from induced pluripotent stem cells
• Cancer immunotherapy using genetically modified immune cells

Email

yuemura●east.ncc.go.jp（Replace ● to @）

Brief History

• 1997 Graduated from Faculty of Dentistry, Niigata University
• 2003 Completed doctoral course in Kumamoto University Graduate School of Medicine
• 2003 Assistant Professor, Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University
• 2005 Lecturer, Saitama Medical University
• 2008 Lecturer, Department of Stem Cell Biology, Kansai Medical University
• 2010 Principal Investigator, Division of Immunology, Aichi Cancer Center Research Institute
• 2013 Laboratory Chief, Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center (Kashiwa)

Professional Memberships

• Japanese Cancer Association
• Japanese Society for Immunology
• Japanese Association of Cancer Immunology (Councillor)
• Japanese Society for Hygiene

Publications

1. kitayama S, Zhang R, Liu T-Y, Ueda N, Iriguchi S, Yasui Y, Kawai Y, Tatsumi M, Hirai N, Mizoro Y, Iwama T, Watanabe A, Nakanishi M, Kuzushima K, Uemura Y, Kaneko S. Cellular adjuvant properties, direct cytotoxicity of re-differentiated Vα24 invariant NKT-like cells from human induced pluripotent stem cells. Stem Cell Reports, 6:213-227, 2016
2. Zhang R, Liu T, Senju S, Haruta M, Hirosawa N, Suzuki M, Tatsumi M, Ueda N, Maki H, Nakatsuka R, Matsuoka Y, Sasaki Y, Tsuzuki S, Nakanishi H, Araki R, Abe M, Akatsuka Y, Sakamoto Y, Sonoda Y, Nishimura Y, Kuzushima K, Uemura Y. Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells. Cancer Immunol Res, 3:668-677, 2015 
3. Uemura Y, Liu TY, Narita Y, Suzuki M, Nakatsuka R, Araki T, Matsumoto M, Iwai LK, Hirosawa N, Matsuoka Y, Murakami M, Kimura T, Hase M, Kohno H, Sasaki Y, Ichihara Y, Ishihara O, Kikuchi H, Sakamoto Y, Jiao SC, Senju S, Sonoda Y. Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Vα24 invariant NKT cells. J Immunol, 183:201-208, 2009 
4. Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur J Immunol, 38:1012-1023, 2008 
5. Uemura Y, Senju S, Maenaka K, Iwai LK, Fujii S, Tabata H, Tsukamoto H, Hirata S, Chen YZ, Nishimura Y. Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for glutamic acid decarboxylase 65-specific TCRs. J Immunol, 170:947-960, 2003