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先端医療開発センター

Home > Yasuhito Uezono, MD, PhD

Yasuhito Uezono, MD, PhDYasuhito Uezono, MD, PhD

上園 保仁

As of 2017, the five-year survival rate for cancer patients has increased more than 60% due to the improvement of early-diagnosis techniques and state-of-the-art therapeutic technologies. However, the number of cancer survivors suffering the side effects of cancer chemotherapy has increased as well. In the Division of Supportive Care Research, we continue to develop novel compounds for intolerable pain and nausea/vomiting that decrease the quality of life of cancer patients. By such translational research, I want to innovate successful treatments for cancer patients.
We are now collaborating with several universities and companies to proceed above activities. We also call our next collaborators to develop novel compounds related to improve QOL of cancer patients. If you have any questions, please contact "yuezono●ncc.go.jp(● replaccce to @)".

Official title

  • Chief, Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center
  • Chief, Division of Cancer Pathophysiology, Research Institute
  • Staff Scientist, Innovation Center for Supportive, Palliative and Psychosocial Care, Hospital
  • Staff Scientist, Division of Health Care Research, Center for Public Health Sciences
  • Professor, Department of Comprehensive Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Visiting Professor, Research Institute for Science & Technology (Translational Research Center), Tokyo University of Science
  • Visiting Professor, Kyushu University of Health and Welfare

Area of research

  • Molecular neuropharmacology
  • Supportive and palliative care research

Keywords

  • Opioid analgesia
  • G protein-coupled receptors(GPCR)
  • Palliative and supportive care
  • Non-labeled, real-time receptor assay

Current main research theme

  • Collaborative study and support of innovation of novel compounds in supportive, palliative care fields.
  • Translational research for the development of novel analgesics for intolerable oral mucositis
  • Development of lipid signaling-modified compounds for treating intolerable pain
  • Development of novel clinically-available opioids with fewer side effects
  • Innovation of compounds for improving symptoms of cancer cachexia - clinical use of ghrelin or des-acyl ghrelin based on their molecular mechanisms of action
  • Research of Japanese kampo medicine to improve QOL in cancer patients

Collaborative research themes

  • G protein-coupled receptor-mediated signaling assay
  • Development of compounds to treat intolerable pain
  • Molecular and cellular mechanisms of action of Japanese herbal kampo medicine
  • Development and support of compounds and methods for the improvement of symptoms of cancer cachexia

Email

yuezono●ncc.go.jp(● replaccce to @)

Brief History

  • 1985  University of Occupational and Environmental Health, M.D.
  • 1989  University of Occupational and Environmental Health, M.D., Ph. D.
  • 1991  Postdoctoral Fellow, Division of Biology, California Institute of Technology
  • 2004  Associate Professor, Department of Molecular and Cellular Biology, Nagasaki University Graduate School of Biomedical Sciences
  • 2009  Chief, Division of Cancer Pathophysiology, National Cancer Center Research Institute
  • 2015  Chief, Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
  • 2015   Staff Scientist, Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital
  • 2015   Staff Scientist, Division of Health Care Research, Center for Public Health Sciences, National Cancer Center
  • 2017 Professor, Department of Comprehensive Oncology, Nagasaki University Graduate School of Biomedical Sciences

Major affiliated societies

  • The Japanese Pharmacological Society(Executive board member、Associate editor of the Editorial Board of Journal of Pharmacological Sciences)
  • Japan Society of Neurovegetative Research(Councilor)
  • The Japanese Society of Neuropsychopharmacology(Councilor)
  • Japanese Association of Supportive Care in Cancer (Councilor, Deputy Director of Kampo Medicine Committee)
  • Japanese Cancer Association
  • Japanese Society for Palliative Medicine
  • Japanese Society for Pharmaceutical Palliative Care and Sciences
  • The Japanese Society of Clinical Pharmacology and Therapeutics
  • Japanese Association for Study of Pain
  • Japan Society of Pain Clinicians

Major Publications

  1. Uezono Y, Miyano K, Sudo Y, Suzuki M, Shiraishi S, Terawaki K. A review of traditional Japanese medicines and their potential mechanism of action. Curr Pharm Des, 18:4839-4853, 2012. [PubMed]
  2. Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Nakata Y, Higami Y, Uezono Y. History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay. J Pharmacol Sci, 126:302-309, 2014. [PubMed]
  3. Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A. Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Mol Psychiatry, 21:1613-1623, 2016. [PubMed]
  4. Terawaki K, Kashiwase Y, Sawada Y, Hashimoto H, Yoshimura M, Ohbuchi K, Sudo Y, Suzuki M, Miyano K, Shiraishi S, Higami Y, Yanagihara K, Hattori T, Kase Y, Ueta Y, Uezono Y. Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the kampo medicine rikkunshito on the model. PLoS One, 12:e0173113, 2017. [PubMed]
  5. Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. Relief from neuropathic pain by blocking of platelet-activating factor-pain loop. FASEB J, Epub ahead of print, 2017. [PubMed]