Jump to Main Contents
研究所ロゴ

Home > Organization > Divisions and Independent Research Units > Group for Development of Molecular diagnostics and Individualized Therapy > Division of Epigenomics > Research Papers

Research Papers

2021

  1. Zhang CD, Takeshima H, Sekine S, Yamashita S, Liu YY, Hattori N, Abe H, Yamashita H, Fukuda M, Imamura Y, Ushiku T, Katai H, Makino H, Watanabe M, Seto Y and Ushijima T.  Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation.  Gastric Cancer, online.  PMID: 34557982
  2. Ushijima T, Clark SJ and Tan P.  Mapping genomic and epigenomic evolution in cancer ecosystems.  Science, 373: 1474-1479, 2021.  PMID: 34554797
  3. Ueda S, Yamashita S, Watanabe SI, Wakabayashi M, Motoi N, Noguchi M, Sekine S, Sato Y and Ushijima T. Influence of degree of DNA degradation in formalin-fixed and paraffin-embedded tissue samples on accuracy of genome-wide DNA methylation analysis. Epigenomics, 13: 565-576, 2021. PMID: 33820444
  4. Yasukawa Y, Hattori N, Iida N, Takeshima H, Maeda M, Kiyono T, Sekine S, Seto Y and Ushijima TSAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation.  Carcinogenesis, 42: 180-189, 2021.  PMID: 33284950
  5. Nitani C, Hara J, Kawamoto H, Taguchi T, Kimura T, Yoshimura K, Hamada A, Kitano S, Hattori N, Ushijima T, Ono H, Nakamoto M, Higuchi T and Sato A. Phase I study of tamibarotene monotherapy in pediatric and young adult patients with recurrent/refractory solid tumors. Cancer Chemother Pharmacol, 88: 99-107, 2021. PMID: 33829292
  6. Ureshino H, Kurahashi Y, Watanabe T, Yamashita S, Kamachi K, Yamamoto Y, Fukuda-Kurahashi Y, Yoshida-Sakai N, Hattori N, Hayashi Y, Kawaguchi A, Tohyama K, Okada S, Harada H, Ushijima T and Kimura S. Silylation of deoxynucleotide analog yields an orally available drug with anti-leukemia effects. Mol Cancer Ther, online. PMID: 34045225
  7. Miyamoto T, Uosaki H, Mizunoe Y, Han SL, Goto S, Yamanaka D, Masuda M, Yoneyama Y, Nakamura H, Hattori N, Takeuchi Y, Ohno H, Sekiya M, Matsuzaka T, Hakuno F, Takahashi SI, Yahagi N, Ito K and Shimano H.  Rapid manipulation of mitochondrial morphology in a living cell with iCMM.  Cell Rep Methods, 1: 100052, 2021.
  8. Suzuki T, Fukuhara S, Nomoto J, Yamashita S, Maeshima AM, Ito Y, Hatta S, Yuda S, Makita S, Munakata W, Suzuki T, Maruyama D, Taniguchi H, Ushijima T, Izutsu K, Tobinai K and Kobayashi Y.  Clinicopathological and genetic features of limited-stage diffuse large B-cell lymphoma with late relapse: targeted sequencing analysis of gene alterations in the initial and late relapsed tumors.  Haematologica, 106: 593-596.  PMID: 32336683
  9. Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R and Ichimura K.  12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.  Neuro Oncol, online. PMID: 34698864
  10. Motoo I, Nanjo S, Ando T, Yamashita S, Ushijima T and Yasuda I.  Methylation silencing of ULK2 via epithelial-mesenchymal transition causes transformation to poorly differentiated gastric cancers.  Gastric Cancer, online.  PMID: 34554345
  11. Katsuda Y, Tanaka K, Mori T, Narita M, Takeshima H, Kondo T, Yamabe Y, Matsufuji M, Sato D, Hamada Y, Yamaguchi K, Ushijima T, Inada E, Kuzumaki N, Iseki M and Narita M.  Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery.  Mol Brain, 14: 146, 2021.  PMID: 34544461
  12. Chiang TH, Maeda M, Yamada H, Chan CC, Chen SL, Chiu SY, Chen YN, Chou YH, Shieh CF, Liu CY, Chiu HM, Chiang H, Shun CT, Lin MW, Wu MS, Lin JT, Chen HH, Ushijima T, Graham DY and Lee YC.  Risk stratification for gastric cancer after Helicobacter pylori eradication: A population-based study on Matsu Islands.  J Gastroenterol Hepatol, 36: 671-679, 2021.  PMID: 32671873

2020

  1. Ishihara H, Yamashita S, Liu YY, Hattori N, El-Omar O, Ikeda T, Fukuda H, Yoshida K, Takagi T, Taneda S, Kondo T, Nagashima Y, Tanabe K and Ushijima T.  Genetic and epigenetic profiling indicate the proximal tubule origin of renal cancers in end-stage renal disease.  Cancer Sci, 111: 4276-4287, 2020.  PMID: 32860304
  2. Takeshima H, Niwa T, Yamashita S, Takamura-Enya T, Iida N, Wakabayashi M, Nanjo S, Abe M, Sugiyama T, Kim YJ and Ushijima T. TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.  J Clin Invest, 130: 5370-5379, 2020.  PMID: 32663196
  3. Takeshima H, Yoda Y, Wakabayashi M, Hattori N, Yamashita S and Ushijima T.  Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level.  Clin Epigenetics, 12: 142, 2020.  PMID: 32958049
  4. Yamashita S, Hattori N, Fujii S, Yamaguchi T, Takahashi M, Hozumi Y, Kogawa T, El-Omar O, Liu YY, Arai N, Mori A, Higashimoto H, Ushijima T and Mukai H.  Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy.  Sci Rep, 10: 15530, 2020.  PMID: 32968149
  5. Kawachi A, Yamashita S, Okochi-Takada E, Hirakawa A, Tsuda H, Shimomura A, Kojima Y, Yonemori K, Fujiwara Y, Kinoshita T, Ushijima T and Tamura K.  BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy.  Breast Cancer Res Treat, 181: 323-329, 2020.  PMID: 32314111
  6. Moro H, Hattori N, Nakamura Y, Kimura K, Imai T, Maeda M, Yashiro M and Ushijima T.  Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.  Gastric Cancer, 23: 105-115, 2020.  PMID: 31555951
  7. Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y and Ushijima T.  Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3.  Gut, 69: 243-251, 2020. P MID: 31085554
  8. Blair VR, McLeod M, Carneiro F, Coit DG, D'Addario JL, van Dieren JM, Harris KL, Hoogerbrugge N, Oliveira C, van der Post RS, Arnold J, Benusiglio PR, Bisseling TM, Boussioutas A, Cats A, Charlton A, Schreiber KEC, Davis JL, Pietro MD, Fitzgerald RC, Ford JM, Gamet K, Gullo I, Hardwick RH, Huntsman DG, Kaurah P, Kupfer SS, Latchford A, Mansfield PF, Nakajima T, Parry S, Rossaak J, Sugimura H, Svrcek M, Tischkowitz M, Ushijima T, Yamada H, Yang HK, Claydon A, Figueiredo J, Paringatai K, Seruca R, Bougen-Zhukov N, Brew T, Busija S, Carneiro P, DeGregorio L, Fisher H, Gardner E, Godwin TD, Holm KN, Humar B, Lintott CJ, Monroe EC, Muller MD, Norero E, Nouri Y, Paredes J, Sanches JM, Schulpen E, Ribeiro AS, Sporle A, Whitworth J, Zhang L, Reeve AE and Guilford P.  Hereditary diffuse gastric cancer: updated clinical practice guidelines.  Lancet Oncol, 21: e386-e397, 2020. PMID: 32758476
  9. Chiang TH, Maeda M, Yamada H, Chan CC, Chen SL, Chiu SY, Chen YN, Chou YH, Shieh CF, Liu CY, Chiu HM, Chiang H, Shun CT, Lin MW, Wu MS, Lin JT, Hsiu-Hsi C, Ushijima T, Graham DY and Lee YC. Risk Stratification for Gastric Cancer after Helicobacter pylori Eradication: A Population-based Study on Matsu Islands. J Gastroenterol Hepatol, online. PMID: 32671873
  10. Watanabe T, Yamashita S, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Yoshida N, Hattori N, Nakamura H, Sato A, Kawaguchi A, Sueoka-Aragane N, Kojima K, Okada S, Ushijima T, Kimura S and Sueoka E.  Targeting Aberrant DNA Hypermethylation as a Driver of ATL Leukemogenesis Using the New Oral Demethylating Agent OR-2100.  Blood, 136: 871-887, 2020.  PMID: 32391874
  11. Nakatani Y, Kato K, Shoji H, Iwasa S, Honma Y, Takashima A, Ushijima T, Ito Y, Itami J and Boku N.  Comparison of involved field radiotherapy and elective nodal irradiation in combination with concurrent chemotherapy for T1bN0M0 esophageal cancer.  Int J Clin Oncol, 25: 1098-1104, 2020.  PMID: 32189155
  12. Sekine S, Yamashita S, Yamada M, Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Ushijima T and Saito Y.  Clinicopathological and molecular correlations in traditional serrated adenoma.  J Gastroenterol, 55: 418-427, 2020.  PMID: 32052185

2019

  1. Yamashita S, Nanjo S, Rehnberg E, Iida N, Takeshima H, Ando T, Maekita T, Sugiyama T and Ushijima T.  Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori.  Clin Epigenetics, 11: 191, 2019.  PMID: 31829249
  2. Iwabu J, Yamashita S, Takeshima H, Kishino T, Takahashi T, Oda I, Koyanagi K, Igaki H, Tachimori Y, Daiko H, Nakazato H, Nishiyama K, Lee YC, Hanazaki K and Ushijima TFGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy.  Sci Rep, 9: 13347, 2019.  PMID: 31527639
  3. Hattori N, Sako M, Kimura K, Iida N, Takeshima H, Nakata Y, Kono Y and Ushijima T.  Novel prodrugs of decitabine with greater metabolic stability and less toxicity.  Clin Epigenetics, 11: 111, 2019.  PMID: 31370878
  4. Zong L, Hattori N, Yasukawa Y, Kimura K, Mori A, Seto Y and Ushijima TLINC00162 Confers Sensitivity to 5-Aza-2'-deoxycytidine via Modulation of an RNA Splicing Protein, HNRNPH1.  Oncogene, in press.  PMID: 30914798
  5. Takeshima H and Ushijima T.  Accumulation of genetic and epigenetic alterations in normal cells and cancer risk.  NPJ Precis Oncol, 3: 7, 2019.  PMID: 30854468
  6. Ushijima T and Suzuki H.  The origin of CIMP, at last.  Cancer Cell, 35: 165-167, 2019.  PMID: 30753821
  7. Hattori N, Niwa T, Ishida T, Kobayashi K, Imai T, Mori A, Kimura K, Mori T, Asami Y and Ushijima T.  Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.  Cancer Sci, 110: 147-156, 2019.  PMID: 30443963
  8. Asano N, Takeshima H, Yamashita S, Takamatsu H, Hattori N, Kubo T, Yoshida A, Kobayashi E, Nakayama R, Matsumoto M, Nakamura M, Ichikawa H, Kawai A, Kondo T and Ushijima T.  Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas.  Sci Rep, 9: 20360, 2019.  PMID: 31889115
  9. Pang K, Park J, Ahn SG, Lee J, Park Y, Ooshima A, Mizuno S, Yamashita S, Park KS, Lee SY, Jeong J, Ushijima T, Yang KM and Kim SJ.  RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triplenegative breast cancers.  Nat Commun, 10: 5805, 2019.  PMID: 31862882
  10. Yatsuoka W, Ueno T, Miyano K, Uezono Y, Enomoto A, Kaneko M, Ota S, Soga T, Sugimoto M and Ushijima T.  Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw.  PLoS One, 14: e0220712, 2019.  PMID: 31404085
  11. Nakano Y, Hasegawa D, Stewart DR, Schultz KAP, Harris AK, Hirato J, Uemura S, Tamura A, Saito A, Kawamura A, Yoshida M, Yamasaki K, Yamashita S, Ushijima T, Kosaka Y, Ichimura K, Dehner LP and Hill DA.  Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation.  Mod Pathol, 32: 1744-1750, 2019.  PMID: 31296931
  12. Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H and Narita M.  Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.  Brain, 42: 1675-1689, 2019.  PMID: 31135049
  13. Zwergel C, Schnekenburger M, Sarno F, Battistelli C, Manara MC, Stazi G, Mazzone R, Fioravanti R, Gros C, Ausseil F, Florean C, Nebbioso A, Strippoli R, Ushijima T, Scotlandi K, Tripodi M, Arimondo PB, Altucci L, Diederich M, Mai A and Valente S.  Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells.  Clin Epigenetics, 11: 68, 2019.  PMID: 31060628
  14. Hironaka-Mitsuhashi A, Tsuda H, Yoshida M, Shimizu C, Asaga S, Hojo T, Tamura K, Kinoshita T, Ushijima T, Hiraoka N and Fujiwara Y.  Invasive breast cancers in adolescent and young adult women show more aggressive immunohistochemical and clinical features than those in women aged 40-44 years.  Breast Cancer, 26: 386-396, 2019.  PMID: 30539373
  15. Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashita S, Takai D, Ushijima T, Nagase T and Hoshi K.  Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: A rare case report and literature review.  BMC Cancer, 19: 52, 2019.  PMID: 30634950
  16. Sugimoto K, Ito T, Lu Z, Hulbert A, Chen C, Orita H, Maeda M, Moro H, Fukagawa T, Ushijima T, Katai H, Wada R, Sato K, Sakamoto K, Yu W, Considine M, Cope L, Herman JG and Brock MV.  DNA methylation genome-wide analysis in remnant and primary gastric cancers.  Gastric Cancer, 22: 1109-1120, 2019.  PMID: 30863929

2018

  1. Ishihara H, Yamashita S, Amano R, Kimura K, Hirakawa K, Ueda T, Murakami Y, Tamori A, Tanabe K, Kawada N, Hagihara A and Ushijima T.  Pancreatic cancer cell fraction estimation in a DNA sample.  Oncology, 95: 370-379, 2018.  PMID: 30149376
  2. Yamashita S, Kishino T, Takahashi T, Shimazu T, Charvat H, Kakugawa Y, Nakajima T, Lee YC, Iida N, Maeda M, Hattori N, Takeshima H, Nagano R, Oda I, Tsugane S, Wu MS and Ushijima T.  Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues.  Proc Natl Acad Sci USA, 115: 1328-1333, 2018.  PMID: 29358395
  3. Iida N, Okuda Y, Ogasawara O, Yamashita S, Takeshima H and Ushijima T.  MACON: a web tool for computing DNA methylation data obtained by the Illumina Infinium Human DNA methylation BeadArray.  Epigenomics, 10: 249-258, 2018.  PMID: 29343101
  4. Ishihara H, Yamashita S, Fujii S, Tanabe K, Mukai H and Ushijima T.  DNA methylation marker to estimate the breast cancer cell fraction in DNA samples.  Med Oncol, 35: 147, 2018.  PMID: 30218172
  5. Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T and Sakuma T.  Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays.  The CRISPR Journal, 1: 337-347, 2018.  PMID: 31021277
  6. Okochi-Takada E, Hattori N, Ito A, Niwa T, Wakabayashi M, Kimura K, Yoshida M and Ushijima T.  Establishment of a high-throughput detection system for DNA demethylating agents.  Epigenetics, 13: 147-155, 2018.  PMID: 27935410
  7. Maeda M, Yamashita S, Shimazu T, Iida N, Takeshima H, Nakajima T, Oda I, Nanjo S, Kusano C, Mori A, Moro H, Yamada H, Tsugane S, Sugiyama T, Sakai Y and Ushijima T.  Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication.  Gastric Cancer, 21: 745-755, 2018.  PMID: 29427040
  8. Hattori N and Ushijima T.  Analysis of DNA Methylation in Tissues Exposed to Inflammation.  Methods Mol Biol, 1725: 185-199, 2018.  PMID: 29322419
  9. Yamaguchi T, Mukai H, Takahashi M, Hara F, Yamauchi C, Yamashita S and Ushijima T.  Predictive value of genetic analysis for pathological complete response to preoperative treatment in HER2 positive, HR negative early breast cancer (PASSION trial).  Jpn J Clin Oncol, 48: 388-391, 2018. PMID: 29506214
  10. Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M, Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki M, Arai H, Sakamoto H, Nishikawa R, Ichimura K; Japan Pediatric Molecular Neuro-Oncology Group (JPMNG).  Significance of molecular classification of ependymomas: C11orf95-RELA fusionnegative supratentorial ependymomas are a heterogeneous group of tumors.  Acta Neuropathol Commun, 6: 134, 2018.  PMID: 30514397
  11. Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D and Hernandez-Vargas H.  Roadmap for investigating epigenome deregulation and environmental origins of cancer.  Int J Cancer, 142: 874-882, 2018.  PMID: 28836271
  12. Tsuchida T, Mano T, Koshi-Mano K, Bannai T, Matsubara T, Yamashita S, Ushijima T, Nagata K, Murayama S, Toda T, Tsuji S and Iwata A.  Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.  Brain Res, 1697: 59-66, 2018.  PMID: 29909202
  13. Yoshida M, Yokota E, Sakuma T, Yamatsuji T, Takigawa N, Ushijima T, Yamamoto T, Fukazawa T and Naomoto Y.  Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma.  Oncotarget, 9: 29220-29232, 2018.  PMID: 30018747
  14. Abe M, Zong L, Abe T, Takeshima H, Ji J, Ushijima T and Hoshi K.  BRAF inhibitor: a novel therapy for ameloblastoma in mandible.  Chin J Cancer Res, 30: 677-678, 2018.

2017

  1. Maeda M, Nakajima T, Oda I, Shimazu T, Yamamichi N, Maekita T, Asada K, Yokoi C, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M and Ushijima T.  High impact of methylation accumulation on metachronous gastric cancer: 5-year follow up of a multicentre prospective cohort study.  Gut, 66: 1721-1723, 2017.  PMID: 28003322
  2. Yamashita S, Iida N, Takeshima H, Hattori N, Maeda M, Kishino T, Nagano R, Shimazu T, Tsugane S and Ushijima T.  A novel method to quantify base substitution mutations at the 10-6 per bp level in DNA samples.  Cancer Lett, 403: 152-158, 2017.  PMID: 28642169
  3. Nakamura Y, Hattori N, Iida N, Yamashita S, Mori A, Kimura K, Yoshino T and Ushijima T.  Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway.  Cancer Lett, 402: 100-109, 2017.  PMID: 28576751
  4. Takeshima H, Niwa T, Toyoda T, Wakabayashi M, Yamashita S and Ushijima T.  Degree of methylation burden is determined by the exposure period to carcinogenic factors.  Cancer Sci, 108: 316-321, 2017.  PMID: 27992956
  5. Maeda M, Moro H and Ushijima T.  Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway.  Gastric Cancer, 20 (Suppl 1): 8-15, 2017.  PMID: 27718135
  6. Yoshida S, Yamashita S, Niwa T, Mori A, Ito S, Ichinose M and Ushijima T.  Epigenetic inactivation of FAT4 contributes to gastric field cancerization.  Gastric Cancer, 20: 136-145, 2017.  PMID: 26792292
  7. Padmanabhan N, Ushijima T and Tan P.  How to stomach an epigenetic insult: the gastric cancer epigenome.  Nat Rev Gastroenterol Hepatol, 14: 467-478, 2017.  PMID:28513632
  8. Fujii S, Yamashita S, Yamaguchi T, Takahashi M, Hozumi Y, Ushijima T and Mukai H.  Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation.  Oncotarget, 8: 19039-19048, 2017.  PMID: 28186977
  9. Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T and Kadomatsu K.  PRC2-mediated transcriptomic alterations at the embryonic stage govern tumorigenesis and clinical outcome in MYCN-driven neuroblastoma.  Cancer Res, 77: 5259-5271, 2017.  PMID: 28807939
  10. Hashimoto T, Yamashita S, Yoshida H, Taniguchi H, Ushijima T, Yamada T, Saito Y, Ochiai A, Sekine S and Hiraoka N.  WNT pathway gene mutations are associated with the presence of dysplasia in colorectal sessile serrated adenoma/polyps.  Am J Surg Pathol, 41: 1188-1197, 2017.  PMID: 28614199
  11. Hironaka-Mitsuhashi A, Matsuzaki J, Takahashi RU, Yoshida M, Nezu Y, Yamamoto Y, Shiino S, Kinoshita T, Ushijima T, Hiraoka N, Shimizu C, Tamura K and Ochiya T.  A tissue microRNA signature that predicts the prognosis of breast cancer in young women.  PLoS One, 12: e0187638, 2017.  PMID: 29141042
  12. Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M and Iwata A.  Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.  Proc Natl Acad Sci USA, 114: E9645-E9654, 2017.  PMID: 29042514
  13. West AC, Tang K, Tye H, Yu L, Deng N, Najdovska M, Lin SJ, Balic JJ, Okochi-Takada E, McGuirk P, Keogh B, McCormack W, Bhathal PS, Reilly M, Oshima M, Ushijima T, Tan P and Jenkins BJ.  Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.  Oncogene, 36: 5134-5144, 2017. PMID: 28481875
  14. Muhammad JS, Nanjo S, Ando T, Yamashita S, Maekita T, Ushijima T, Tabuchi Y and Sugiyama T.  Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis.  Int J Cancer, 140: 2272-2283, 2017.  PMID: 28214334
  15. Narita M, Shimura E, Nagasawa A, Aiuchi T, Suda Y, Hamada Y, Ikegami D, Iwasawa C, Arakawa K, Igarashi K, Kuzumaki N, Yoshioka Y, Ochiya T, Takeshima H, Ushijima T and Narita M.  Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c.  PLoS One, 12: e0172115, 2017.  PMID: 28225782
  16. Fukushima S, Yamashita S, Kobayashi H, Takami H, Fukuoka K, Nakamura T, Yamasaki K, Matsushita Y, Nakamura H, Totoki Y, Kato M, Suzuki T, Mishima K, Yanagisawa T, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Nagane M, Iuchi T, Yoshimoto K, Mizoguchi M, Tamura K, Sakai K, Sugiyama K, Nakada M, Yokogami K, Takeshima H, Kanemura Y, Matsuda M, Matsumura A, Kurozumi K, Ueki K, Nonaka M, Asai A, Kawahara N, Hirose Y, Takayama T, Nakazato Y, Narita Y, Shibata T, Matsutani M, Ushijima T, Nishikawa R, Ichimura K on behalf of The Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium).  Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas.  Acta Neuropathol, 133: 445-462, 2017.  PMID: 28078450
  17. Nakamura T, Yamashita S, Fukumura K, Nakabayashi J, Tanaka K, Tamura K, Tateishi K, Kinoshita M, Fukushima S, Takami H, Fukuoka K, Yamazaki K, Matsushita Y, Ohno M, Miyakita Y, Shibui S, Kubo A, Shuto T, Kocialkowski S, Yamanaka S, Mukasa A, Sasayama T, Mishima K, Maehara T, Kawahara N, Nagane M, Narita Y, Mano H, Ushijima T and Ichimura K.  Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma.  Acta Neuropathol, 133: 321-324, 2017.   PMID: 28058506
  18. Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y and Guo M.  Meeting report of the fifth international cancer epigenetics conference in Beijing, China, October 2016.  Epigenomics, 9: 937-941, 2017.  PMID: 28530839

 

2016

  1. Kishino T, Niwa T, Yamahsita S, Takahashi T, Nakazato H, Nakajima T, Igaki H, Tachimori Y, Suzuki Y and Ushijima T.  Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.  Mol Carcinogenesis, 55: 2077-2088, 2016.  PMID: 26756304
  2. Ushijima T and Yoshino T.  The moment that KRAS mutation started to evolve into precision medicine in metastatic colorectal cancer.  Cancer Res, 76: 6443-6444, 2016.  PMID: 28148677
  3. Zong L, Hattori N, Yoda Y, Yamashita S, Takeshima H, Takahashi T, Maeda M, Katai H, Nanjo S, Ando T, Seto Y, and Ushijima T.  Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.  Gastric Cancer, 19: 361-369, 2016.  PMID: 25678126
  4. Nakazato H, Takeshima H, Kishino T, Kubo E, Hattori N, Nakajima T, Yamashita S, Igaki H, Tachimori Y, Kuniyoshi Y and Ushijima T.  Early-stage induction of SWI/SNF mutations during esophageal squamous cell carcinogenesis.  PLoS One, 11: e0147372, 2016.  PMID: 26812616
  5. Hattori N and Ushijima T.  Epigenetic impact of infection on carcinogenesis: mechanisms and applications.  Genome Med, 8: 10, 2016.  PMID: 26823082
  6. Mori G, Nakajima T, Asada K, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Fujishiro M, Gotoda T, Ichinose M, Ushijima T and Oda I.  Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan.  Gastric Cancer, 19: 911-918, 2016.  PMID: 26420267
  7. Abe M, Yamashita S, Mori Y, Abe T, Saijo H, Hoshi K, Ushijima T and Takato T.  High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes.  BMC Cancer, 16: 350, 2016.  PMID: 27255271
  8. Sekine S, Yamashita S, Tanabe T, Hashimoto T, Yoshida H, Taniguchi H, Kojima M, Shinmura K, Saito Y, Hiraoka N, Ushijima T and Ochiai A.  Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.  J Pathol, , 239: 133-138, 2016.  PMID: 26924569
  9. Sasaki Y, Hamaguchi T, Yamada Y, Takahashi N, Shoji H, Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Nagai Y, Taniguchi H, Boku N, Ushijima T and Shimada Y.  Value of KRAS, BRAF, and PIK3CA Mutations and Survival Benefit from Systemic Chemotherapy in Colorectal Peritoneal Carcinomatosis.  Asian Pac J Cancer Prev, 17: 539-543, 2016.  PMID: 26925640
  10. Matsuda Y, Ishiwata T, Yoshimura H, Yamashita S, Ushijima T and Arai T.  Systemic administration of small interfering RNA targeting human nestin inhibits pancreatic cancer cell proliferation and metastasis.  Pancreas, 45: 93-100, 2016.  PMID: 26335012
  11. Ichimura K, Fukushima S, Totoki Y, Matsushita Y, Otsuka A, Tomiyama A, Niwa T, Takami H, Nakamura T, Suzuki T, Fukuoka K, Yanagisawa T, Mishima K, Nakazato Y, Hosoda F, Narita Y, Shibui S, Yoshida A, Mukasa A, Saito N, Kumabe T, Kanamori M, Tominaga T, Kobayashi K, Shimizu S, Nagane M, Iuchi T, Mizoguchi M, Yoshimoto K, Tamura K, Maehara T, Sugiyama K, Nakada M, Sakai K, Kanemura Y, Nonaka M, Asai A, Yokogami K, Takeshima H, Kawahara N, Takayama T, Yao M, Kato M, Nakamura H, Hama N, Sakai R, Ushijima T, Matsutani M, Shibata T, Nishikawa R and The Intracranial Germ Cell Tumor Genome Analysis Consortium.  Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy.  Acta Neuropathol, 131: 889-901, 2016.  PMID: 26956871
  12. Nakamura T, Tateishi K, Niwa T, Matsushita Y, Tamura K, Kinoshita M, Tanaka K, Fukushima S, Takami H, Arita H, Kubo A, Shuto T, Ohno M, Miyakita Y, Kocialkowski S, Sasayama T, Hashimoto N, Maehara T, Shibui S, Ushijima T, Kawahara N, Narita Y and Ichimura K.  Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas.  Neuropathol Appl Neurobiol, 42: 279-290, 2016.  PMID: 26111727
  13. Kuboki Y, Yamashita S, Niwa T, Ushijima T, Nagatsuma A, Kuwata T, Yoshino T, Doi T, Ochiai A and Ohtsu A.  Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer.  Ann Oncol, 27: 127-133, 2016.  PMID: 26489445

 

2015

  1. Asada K, Nakajima T, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Oda I, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M and Ushijima T.  Demonstration of the usefulness of epigenetic cancer risk prediction by a multicenter prospective cohort study.  Gut, 64: 388-396, 2015.  PMID: 25379950
  2. Takeshima H, Wakabayashi M, Hattori N, Yamashita S and Ushijima T.  Identification of co-existence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.  Carcinogenesis, 36: 192-201, 2015.  PMID: 25477340
  3. Takeshima H, Niwa T, Takahashi T, Wakabayashi M, Yamashita S, Ando T, Inagawa Y, Taniguchi H, Katai H, Sugiyama T, Kiyono T and Ushijima T.  Frequent involvement of chromatin remodeler alterations in gastric field cancerization.  Cancer Lett, 357: 328-338, 2015.  PMID: 25462860
  4. Takahashi T, Yamashita S, Matsuda Y, Kishino T, Nakajima T, Kushima R, Kato K, Igaki H, Tachimori Y, Osugi H, Nagino M and Ushijima TZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.  J Cancer Res Clin Oncol, 141: 453-463, 2015.  PMID: 25273507
  5. Yoda Y, Takeshima H, Niwa T, Kim JG, Ando T, Kushima R, Sugiyama T, Katai H, Noshiro H and Ushijima T.  Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.  Gastric Cancer, 18: 65-76, 2015.  PMID: 24510342
  6. Wei FZ, Cao Z, Wang X, Wang H, Cai MY, Li T, Hattori N, Wang D, Du Y, Song B, Cao LL, Shen C, Wang L, Wang H, Yang Y, Xie D, Wang F, Ushijima T, Zhao Y and Zhu WG.  Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTORdependent pathway.  Autophagy, 11: 2309-2322, 2015.  PMID: 26735435
  7. Shimazu T, Asada K, Charvat H, Kusano C, Otake Y, Kakugawa Y, Watanabe H, Gotoda T, Ushijima T and Tsugane S.  Association of gastric cancer risk factors with DNA methylation healthy Japanese: a cross-sectional study.  Carcinogenesis, 36: 1291-1298, 2015.  PMID: 26354778
  8. Yamaguchi T, Mukai H, Yamashita S, Fujii S and Ushijima T.  Comprehensive DNA methylation and extensive mutation analyses of HER2-positive breast cancer.  Oncology, 88: 377-384, 2015.  PMID: 25591616
  9. Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V and Narita M.  Epigenetic mechanisms of chronic pain.  Trends Neurosci, 38: 237-246, 2015.  PMID: 25765319

 

2014

  1. Okochi-Takada E, Hattori N, Tsukamoto T, Miyamoto K, Ando T, Ito S, Yamamura Y, Wakabayashi M, Nobeyama Y and Ushijima T.  ANGPTL4 is a secreted tumor-suppressor that inhibits angiogenesis.  Oncogene, 33: 2273-2278, 2014.  PMID: 23686315
  2. Hattori N and Ushijima T.  Compendium of aberrant DNA methylation and histone modifications in cancer.  Biochem Biophys Res Commun, 455: 3-9, 2014.  PMID: 25194808
  3. Ushijima T.  Cancer epigenetics: Now harvesting fruit and seeding for common diseases.  Biochem Biophys Res Commun, 455: 1-2, 2014.  PMID: 25434294
  4. Ueda Y, Ando T, Nanjo S, Ushijima T and Sugiyama T.  DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis.  Dig Dis Sci, 59: 2444-2451, 2014.  PMID: 24825593
  5. Yamada M, Fukagawa T, Nakajima T, Asada K, Sekine S, Yamashita S, Okochi-Takada E, Taniguchi H, Kushima R, Oda I, Saito Y, Ushijima T and Katai H.  Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1.  Gastric Cancer, 17: 750-756, 2014.  PMID: 24037103
  6. Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, Zhang L, Zhu B, Hattori N, Ji J, Yuasa Y, Kim W, Ushijima T, Shi H and Deng D.  Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.  Clin Cancer Res, 20: 4598-4612, 2014.  PMID: 25009298
  7. Brücher BL, Lyman G, van Hillegersberg R, Pollock RE, Lordick F, Yang HK, Ushijima T, Yeoh KG, Skricka T, Polkowski W, Wallner G, Verwaal V, Garofalo A, D'Ugo D, Roviello F, Steinau HU, Wallace TJ, Daumer M, Maihle N, Reid TJ III, Ducreux M, Kitagawa Y, Knuth A, Zilberstein B, Steele SR and Jamall IS.  Imagine a world without cancer.  BMC Cancer, 14: 186, 2014.  PMID: 24629025
  8. Imaoka T, Nishimura M, Doi K, Tani S, Ishikawa K, Yamashita S, Ushijima T, Imai T and Shimada Y.  Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis.  Int J Cancer , 134: 1529-1538, 2014.  PMID: 24105445
  9. Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, Oka M, Watanabe M, Enomoto S, Niwa T, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Takeshita T, Ushijima T and Ichinose M.  Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer.  Int J Cancer, 134: 1445-1457, 2014.  PMID: 24009139

 

2013

  1. Niwa T, Toyoda T, Tsukamoto T, Mori A, Tatematsu M and Ushijima T.  Prevention of Helicobacter pylori–induced gastric cancers in gerbils by a DNA demethylating agent.  Cancer Prev Res, 6: 263-270, 2013.  PMID: 23559452
  2. Hattori N, Niwa T, Kimura K, Helin K and Ushijima T.  Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells.  Nucleic Acids Res, 41: 7231-7239, 2013.  PMID: 23761442
  3. Takahashi T, Matsuda Y, Yamashita S, Hattori N, Kushima R, Lee YC, Igaki H, Tachimori Y, Nagino M and Ushijima T.  Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.  PLoS One, 8: e82302, 2013.  PMID: 24312652
  4. Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ and Ushijima T.  Interleukin-1b induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis.  Cancer Lett, 340: 141-147, 2013.  PMID: 23920123
  5. Asada K, Ando T, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, Yoshida T, Miyamoto K, Enomoto S, Ichinose M, Tsukamoto T, Ito S, Tatematsu M, Sugiyama T and Ushijima TFHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect.  Oncogene, 32: 2140-2149, 2013.  PMID: 22689052
  6. Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH and Ushijima T.  Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers.  Cancer Lett, 330: 33-40, 2013.  PMID: 23196062
  7. Asada K, Abe M and Ushijima T.  Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas.  J Hum Genet, 58: 428-433, 2013.  PMID: 23739128
  8. Asada K, Watanabe N, Nakamura Y, Ohira M, Westermann F, Schwab M, Nakagawara A and Ushijima T.  Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas.  Jpn J Clin Oncol, 43: 641-645, 2013.  PMID: 23619990
  9. Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ushijima T and Ichinose M.  Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis.  Gastric Cancer, 16: 488-497, 2013.  PMID: 23292007
  10. Suzuki T, Yamashita S, Ushijima T, Takumi S, Sano T, Michikawa T and Nohara K.  Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors.  Cancer Sci, 104: 1575-1585, 2013.  PMID: 24118411
  11. Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H and Nakagawara A.  Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.  J Clin Invest, 123: 2935-2947, 2013.  PMID: 23778138
  12. Ito Y, Yamada Y, Asada K, Ushijima T, Iwasa S, Kato K, Hamaguchi T and Shimada Y.  EGFR L2 domain mutation is not correlated with resistance to cetuximab in metastatic colorectal cancer patients.  J Cancer Res Clin Oncol, 139: 1391-1396, 2013.  PMID: 23722667
  13. Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, Okano HJ, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T and Narita M.  Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.  Brain, 136: 828-843, 2013.  PMID: 23364351
  14. Hirata A, Utika J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K and Yamada Y.  Dose-dependent roles for canonical Wnt signaling in de novo crypt formation and cell cycle properties of the colonic epithelium.  Development, 140: 66-75, 2013.  PMID: 23222438

 

2012

  1. Takeshima H, Ikegami D, Wakabayashi M, Niwa T, Kim YJ and Ushijima T.  Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.  Carcinogenesis, 33: 2384-2390, 2012.  PMID: 22976929
  2. Ushijima T and Hattori N.  Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers.  Clin Cancer Res, 18: 923-929, 2012.  PMID: 22205689
  3. Shigematsu Y, Niwa T, Yamashita S, Taniguchi H, Kushima R, Katai H, Ito S, Tsukamoto T, Ichinose M and Ushijima T.  Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers.  Oncol Lett, 4: 268-274, 2012.  PMID: 22844368
  4. Nanjo S, Asada K, Yamashita S, Nakajima T, Nakazawa K, Maekita T, Ichinose M, Sugiyama T and Ushijima T.  Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection.  Gastric Cancer, 15: 382-388, 2012.  PMID: 22237657
  5. Matsuda Y, Yamashita S, Lee YC, Niwa T, Yoshida T, Gyobu K, Igaki H, Kushima R, Lee S, Wu MS, Osugi H, Suehiro S and Ushijima T.  Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization.  Cancer Causes Control, 23: 865-873, 2012.  PMID: 22527164
  6. Kikuyama M, Takeshima H, Kinoshita T, Okochi-Takada E, Wakabayashi M, Akashi-Tanaka S, Ogawa T, Seto Y and Ushijima T.  Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.  Cancer Lett, 322: 204-212, 2012.  PMID: 22433712
  7. Katsurano M, Niwa T, Yasui Y, Shigematsu Y, Yamashita S, Takeshima H, Lee MS, Kim YJ, Tanaka T and Ushijima T.  Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction.  Oncogene, 31: 342-351, 2012.  PMID: 21685942
  8. Chiba T, Marusawa H and Ushijima T.  Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.  Gastroenterol, 143: 550-563, 2012.  PMID: 22796521
  9. Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T and Ichinose M.  Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis.  Int J Cancer, 131: 2632-2642, 2012.  PMID: 22383377
  10. Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa TO and Oshima M.  Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells.  Oncogene, 31: 3949-3960, 2012.  PMID: 22139078
  11. Frau M, Tomasi ML, Simile MM, Demartis MI, Salis F, Latte G, Calvisi DF, Seddaiu MA, Daino L, Feo CF, Brozzetti S, Solinas G, Yamashita S, Ushijima T, Feo F and Pascale RM.  Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.  Hepatology, 56: 165-175, 2012.  PMID: 22318685

2011

  1. Takeshima H, Yamashita S, Shimazu T and Ushijima T.  Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.  Genomics, 98: 182-188, 2011.  PMID: 21683780
  2. Hattori N, Okochi-Takada E, Kikuyama M, Wakabayashi M, Yamashita S and Ushijima T.  Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.  Cancer Sci, 102: 1337-1343, 2011.  PMID: 21489049
  3. Gyobu K, Yamashita S, Matsuda Y, Igaki H, Niwa T, Oka D, Kushima R, Osugi H, Lee S, Suehiro S and Ushijima T.  Identification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas.  Ann Surg Oncol, 18: 1185-1194, 2011.  PMID: 21042947
  4. Hur K, Niwa T, Toyoda T, Tsukamoto T, Tatematsu M, Yang HK and Ushijima T.  Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation.  Carcinogenesis, 32: 35-41, 2011.  PMID: 20980348
  5. Yoshida T, Yamashita S, Takamura-Enya T, Niwa T, Ando T, Enomoto S, Maekita T, Nakazawa K, Tatematsu M, Ichinose M and Ushijima T.  Alu and Satα hypomethylation in Helicobacter pylori-infected gastric mucosae.  Int J Cancer, 128: 33-39, 2011.  PMID: 20602342
  6. Kuzumaki N, Ikegami D, Tamura R, Hareyama N, Imai S, Narita M, Torigoe K, Niikura K, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T, Suzuki T and Narita M.  Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment.  Hippocampus, 21: 127-132, 2011.  PMID: 20232397
  7. Lee YC, Wang HP, Wang CP, Ko JY, Lee JM, Chiu HM, Lin JT, Yamashita S, Oka D, Watanabe N, Matsuda Y, Ushijima T and Wu MS.  Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers.  Cancer Prev Res, 4: 1982-1992, 2011.  PMID: 21952583
  8. Cai LY, Izumi S, Abe M, Imura M, Yasugi T, Wakazono K, Ohnuki Y, Kondo A and Ushijima T.  Does Aberrant DNA Methylation Occur in Human Uterine Leiomyomas? An Attempt of Genome-Wide Screening by MS-RDA.  Tokai J Exp Clin Med, 36: 84-90, 2011.  PMID: 21932190
  9. Colombo F, Falvella FS, Galvan A, Frullanti E, Kunitoh H, Ushijima T and Dragani TA.  A 5’-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A.  Mol Cancer, 10: 81, 2011.  PMID: 21736709

 

2010

  1. Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M and Ushijima T.  Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.  Cancer Res, 70: 1430-1440, 2010.  PMID: 20124475
  2. Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, Oda I, Gotoda T and Ushijima T.  Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication.  J Gastroenterol, 45: 37-44, 2010.  PMID: 19821005
  3. Niwa T and Ushijima T.  Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis.  Adv Genet, 71: 41-56, 2010.  PMID: 20933125
  4. Takeshima H and Ushijima T.  Methylation destiny: Moira takes account of histones and RNA polymerase II.  Epigenetics, 5: 89-95, 2010.  PMID: 20160507
  5. Ushijima T and Asada K.  Aberrant DNA methylation in contrast with mutations.  Cancer Sci, 101: 300-305, 2010.  PMID: 19958364
  6. Herceg Z and Ushijima T.  Epigenetics is a fascinating field of modern biology. Preface.  Adv Genet, 71: xi-xii, 2010.  PMID: 20933123
  7. Herceg Z and Ushijima T.  Introduction: epigenetics and cancer.  Adv Genet, , 70: 1-23, 2010.  PMID: 20920743
  8. Ikegami D, Narita M, Imai S, Miyashita K, Tamura R, Takagi S, Yokomizo A, Takeshima H, Ando T, Igarashi K, Kanno J, Kuzumaki N, Ushijima T and Suzuki T.  Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine.  Addict Biol, 15: 358-361, 2010.  PMID: 20624155
  9. Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T and Ochiai A.  Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts.  Int J Oncol, 37: 317-325, 2010.  PMID: 20596659
  10. Kuzumaki N, Ikegami D, Imai S, Narita M, Tamura R, Yajima M, Suzuki A, Miyashita K, Niikura K, Takeshima H, Ando T, Ushijima T and Suzuki T.  Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice.  Synapse, 64: 721-728, 2010.  PMID: 20336624
  11. Kuzumaki N, Ikegami D, Tamura R, Sasaki T, Niikura K, Narita M, Miyashita K, Imai S, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T and Suzuki T.  Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging.  Synaps, 64: 611-616, 2010.  PMID: 20340168
  12. Tomita H, Hirata A, Yamada Y, Hata K, Oyama T, Mori H, Yamashita S, Ushijima T and Hara A.  Suppressive effect of global DNA hypomethylation on gastric carcinogenesis.  Carcinogenesis, 31: 1627-1633, 2010.  PMID: 20622006

 

2009

  1. Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, Sugiyama T and Ushijima T.  DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect.  Int J Cancer, 124: 2367-2374, 2009.  PMID: 19165869
  2. Hosoya K, Yamashita S, Ando T, Nakajima T, Itoh F and Ushijima T.  Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis.  Cancer Lett, 285: 182-189, 2009.  PMID: 19527921
  3. Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K and Ushijima T.  The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.  Int J Cancer, 124: 905-910, 2009.  PMID: 19035455
  4. Oka D, Yamashita S, Tomioka T, Nakanishi Y, Kato H, Kaminishi M and Ushijima T.  The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers.  Cancer, 115: 3412-3426, 2009.  PMID: 19472401
  5. Takeshima H, Yamashita S, Shimazu T, Niwa T and Ushijima T.  The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.  Genome Res, 19: 1974-1982, 2009.  PMID: 19652013
  6. Terada K, Okochi-Takada E, Akashi-Tanaka S, Miyamoto K, Taniyama K, Tsuda H, Asada K, Kaminishi M and Ushijima T.  Association between frequent CpG island methylation and HER2 amplification in human breast cancers.  Carcinogenesis, 30: 466-471, 2009.  PMID: 19168584
  7. Yamashita S, Hosoya K, Gyobu K, Takeshima H and Ushijima T.  Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis.  DNA Res, 16: 275-286, 2009.  PMID: 19767598
  8. Ushijima T and Yamashita S.  Methylation-sensitive representational difference analysis (MS-RDA).  Methods Mol Biol, 507: 117-130, 2009.  PMID: 18987811
  9. Akagi I, Miyashita M, Makino H, Nomura T, Hagiwara N, Takahashi K, Cho K, Mishima T, Ishibashi O, Ushijima T, Takizawa T and Tajiri T.  Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma.  Int J Oncol, 34: 767-775, 2009.  PMID: 19212681
  10. Cho YM, Imai T, Hasumura M, Watanabe N, Ushijima T, Hirose M and Nishikawa A.  Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.  J Toxicol Sci, 34: 407-412, 2009.  PMID: 19652463
  11. Ogasawara N, Tsukamoto T, Mizoshita T, Inada KI, Ban H, Kondo S, Takasu S, Ushijima T, Ito K, Ito Y, Ichinose M, Ogawa T, Joh T and Tatematsu M.  RUNX3 expression correlates with chief cell differentiation in human gastric cancers.  Histol Histopathol, 24: 31-40, 2009.  PMID: 19012242

 

2008

  1. Abe M, Watanabe N, McDonell N, Takato T, Ohira M, Nakagawara A and Ushijima T.  Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis.  Oncology, 74: 50-60, 2008.  PMID: 18544995
  2. Imaoka T, Yamashita S, Nishimura M, Kakinuma S, Ushijima T and Shimada Y.  Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas.  J Radiat Res (Tokyo), 49: 349-360, 2008.  PMID: 18421211
  3. Jones PA, Baylin SB, Bernsten BE, Feinberg AP, Greally JM, Jenuwein T, Jirtle R, Ushijima T, Pierotta V, Allis CD, Elgin SC, Rine J and Wu C.  Moving AHEAD with an international human epigenome project.  Nature, 454: 711-715, 2008.  PMID: 18685699
  4. Yamashita S, Takahashi S, McDonell N, Watanabe N, Niwa T, Hosoya K, Tsujino Y, Shirai T and Ushijima T.  Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers.  Cancer Res, 68: 2112-2121, 2008.  PMID: 18381416
  5. Zhao Y, Miyashita K, Ando T, Kakeji Y, Yamanaka T, Taguchi K, Ushijima T, Oda S and Maehara Y.  Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1.  Gene, 423: 188-193, 2008.  PMID: 18692554
  6. Nakajima T, Enomoto S and Ushijima T.  DNA methylation: a marker for carcinogen exposure and cancer risk.  Environ Health Prev Med, 13: 8-15, 2008.  PMID: 19568874

 

2007

  1. Abe M, Westermann F, Nakagawara A, Takato T, Schwab M and Ushijima T.  Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas.  Cancer Lett, 247: 253-258, 2007.  PMID: 16759796
  2. Cai LY, Abe M, Izumi S, Imura M, Yasugi T and Ushijima T.  Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers.  Life Sci, 80: 1458-1465, 2007.  PMID: 17303177
  3. Enomoto S, Maekita T, Tsukamoto T, Nakajima T, Nakazawa K, Tatematsu M, Ichinose M and Ushijima T.  Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae.  Cancer Sci, 98: 1853-1861, 2007.  PMID: 17900260
  4. Hsu CH, Stedeford T, Okochi-Takada E, Ushijima T, Noguchi H, Muro-Cacho C, Holder JW and Banasik M.  Framework analysis for the carcinogenic mode of action of nitrobenzene.  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 25: 155-184, 2007.  PMID: 17558784
  5. Moriguchi K, Yamashita S, Tsujino Y, Tatematsu M and Ushijima T.  Larger numbers of silenced genes in cancer cell lines with increased de novo methylation of scattered CpG sites.  Cancer Lett, 249: 178-187, 2007.  PMID: 16971039
  6. Nobeyama Y, Okochi-Takada E, Furuta J, Miyagi Y, Kikuchi K, Yamamoto A, Nakanishi Y, Nakagawa H and Ushijima T.  Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.  Int J Cancer, 121: 301-307, 2007.  PMID: 17372906
  7. Takasu S, Tsukamoto T, Ushijima T, Yamashita S, Ogasawara N, Ban H, Yanai T, Masegi T and Tatematsu M.  Cyclin D1 overexpression in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas.  Exp Toxicol Pathol, 59: 171-175, 2007.  PMID: 17855062
  8. Ushijima T.  Epigenetic field for cancerization.  J Biochem Mol Biol, 40: 142-150, 2007.  PMID: 17394762

 

2006

  1. Mihara M, Yoshida Y, Tsukamoto T, Inada K, Nakanishi Y, Yagi Y, Imai K, Sugimura T, Tatematsu M and Ushijima T.  Methylation of multiple genes in gastric glands with intestinal metaplasia: a disorder with polyclonal origins.  Am J Pathol, 169: 1643-1651, 2006.  PMID: 17071588
  2. Nakajima T, Maekita T, Oda I, Gotoda T, Yamamoto S, Umemura S, Ichinose M, Sugimura T, Ushijima T and Saito D.  Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers.  Cancer Epidemiol Biomarkers Prev, 15: 2317-2321, 2006.  PMID: 17119066
  3. Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K and Ushijima T.  Silencing of peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.  Cancer Res, 66: 6080-6086, 2006.  PMID: 16778180
  4. Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T and Sasaki H.  Genome-wide profiling of promoter methylation in human.  Oncogene, 25: 3059-3064, 2006.  PMID: 16407832
  5. Imura M, Yamashita S, Cai LY, Furuta JI, Wakabayashi M, Yasugi T and Ushijima T.  Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 ovarian cancer cell lines.  Cancer Lett, 241: 213-220, 2006.  PMID: 16303245
  6. Lieb JD, Beck S, Bulyk ML, Farnham P, Hattori N, Henikoff S, Liu XS, Okumura K, Shiota K, Ushijima T and Greally JM.  Applying whole-genome studies of epigenetic regulation to study human disease.  Cytogenet Genome Res, 114: 1-15, 2006.  PMID: 16717444
  7. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M and Ushijima T.  High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.  Clin Cancer Res, 12: 989-995, 2006.  PMID: 16467114
  8. Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Baba T, Shibuya K, Shibuya A, Kawabe Y and Yanagisawa J.  A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.  EMBO J, 25: 1081-1092, 2006.  PMID: 16498406
  9. Okochi-Takada E, Nakazawa K, Wakabayashi M, Mori A, Ichimura S, Yasugi T and Ushijima T.  Silencing of the UCHL1 gene in human colorectal and ovarian cancers.  Int J Cancer, 119: 1338-1344, 2006.  PMID: 16642472
  10. Ushijima T, Nakajima T and Maekita T.  DNA methylation as a marker for the past and future.  J Gastroenterol, 41: 401-407, 2006.  PMID: 16799880
  11. Watanabe N, Okochi-Takada E, Yagi Y, Furuta JI and Ushijima T.  Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island.  Curr Top Microbiol Immunol, 310: 199-210, 2006.  PMID: 16909912
  12. Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M and Ushijima T.  Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.  Cancer Sci, 97: 64-71, 2006.  PMID: 16367923

 

2005

  1. Yamashita S, Wakazono K, Nomoto T, Tsujino Y, Kuramoto T and Ushijima T.  Expression quantitative trait Loci analysis of 13 genes in the rat prostate.  Genetics, 171: 1231-1238, 2005.  PMID: 16079240
  2. Yamashita S, Suzuki S, Nomoto T, Kondo Y, Wakazono K, Tsujino Y, Sugimura T, Shirai T, Homma Y and Ushijima T.  Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.  Cancer Res, 65: 2610-2616, 2005.  PMID: 15805257
  3. Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T and Kaneda A.  Decreased fidelity in replicating CpG methylation patterns in cancer cells.  Cancer Res, 65: 11-17, 2005.  PMID: 15665274
  4. Ushijima T and Okochi-Takada E.  Aberrant methylations in cancer cells: Where do they come from?  Cancer Sci, 96: 206-211, 2005.  PMID: 15819717
  5. Ushijima T.  Detection and interpretation of altered methylation patterns in cancer cells.  Nat Rev Cancer, 5: 223-231, 2005.  PMID: 15719030
  6. Tsukamoto T, Mizoshita T, Mihara M, Tanaka H, Takenaka Y, Yamamura Y, Nakamura S, Ushijima T and Tatematsu M.  Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes.  Histopathology, 46: 649-658, 2005.  PMID: 15910596
  7. Niwa T, Yamashita S, Tsukamoto T, Kuramoto T, Nomoto T, Wakazono K, Fujita H, Matsushima T, Tatematsu M, Sugimura T and Ushijima T.  Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas.  Cancer Sci, 96: 409-413, 2005.  PMID: 16053512
  8. Miyamoto K and Ushijima T.  Diagnostic and therapeutic applications of epigenetics.  Jpn J Clin Oncol, 35: 293-301, 2005.  PMID: 15930038
  9. Miyamoto K, Fukutomi T, Akashi-Tanaka S, Hasegawa T, Asahara T, Sugimura T and Ushijima T.  Identification of 20 genes aberrantly methylated in human breast cancers.  Int J Cancer, 116: 407-414, 2005.  PMID: 15818620
  10. Kuramoto T, Morimura K, Nomoto T, Namiki C, Hamada S, Fukushima S, Sugimura T, Serikawa T and Ushijima T.  Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17.  J Hered, 96: 339-345, 2005.  PMID: 15829729
  11. Goldberg GS, Kunimoto T, Alexander DB, Suenaga K, Ishidate F, Miyamoto K, Ushijima T, Teng CT, Yokota J, Ohta T and Tsuda H.  Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes.  Med Chem, 1: 57-64, 2005.  PMID: 16789886
  12. Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T and Ushijima T.  Silencing of the thrombomodulin gene in human malignant melanoma.  Melanoma Res, 15: 15-20, 2005.  PMID: 15714116
  13. Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y and Bae SC.  RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor beta-activated SMAD.  Mol Cell Biol, 25: 8097-8107, 2005.  PMID: 16135801
  14. Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A and Ushijima T.  CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas.  Cancer Res, 65: 828-834, 2005.  PMID: 15705880

 

2004

  1. Yamashita S, Nomoto T, Abe M, Tatematsu M, Sugimura T and Ushijima T.  Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers.  Mutat Res, 549: 185-193, 2004.  PMID: 15120970
  2. Ushijima T and Sasako M.  Focus on gastric cancer.  Cancer Cell, 5: 121-125, 2004.  PMID: 14998488
  3. Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S and Tatematsu M.  Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.  J Cancer Res Clin Oncol, 130: 135-145, 2004.  PMID: 14655050
  4. Takada T, Yagi Y, Maekita T, Imura M, Nakagawa S, Tsao SW, Miyamoto K, Yoshino O, Yasugi T, Taketani Y and Ushijima T.  Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers.  Cancer Sci, 95: 741-744, 2004.  PMID: 15471560
  5. Okochi-Takada E, Ichimura S, Kaneda A, Sugimura T and Ushijima T.  Establishment of a detection system for demethylating agents using an endogenous promoter CpG island.  Mutat Res, 568: 187-194, 2004.  PMID: 15542106
  6. Mizoshita T, Inada K, Tsukamoto T, Nozaki K, Joh T, Itoh M, Yamamura Y, Ushijima T, Nakamura S and Tatematsu M.  Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.  J Cancer Res Clin Oncol, 130: 29-36, 2004.  PMID: 14615935
  7. Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, Kaminishi M, Sugimura T and Ushijima TLysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res, 64: 6410-6415, 2004.  PMID: 15374948
  8. Kaneda A, Tsukamoto T, Takamura-Enya T, Watanabe N, Kaminishi M, Sugimura T, Tatematsu M and Ushijima T.  Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation.  Cancer Sci, 95: 58-64, 2004.  PMID: 14720328
  9. Kaneda A, Kaminishi M, Sugimura T and Ushijima T.  Decreased expression of the seven ARP02月03日 complex genes in human gastric cancers.  Cancer Lett, 212: 203-210, 2004.  PMID: 15279900
  10. Hoshi M, Morimura K, Wanibuchi H, Wei M, Okochi E, Ushijima T, Takaoka K and Fukushima S.  No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.  Toxicol Sci, 81: 273-279, 2004.  PMID: 15282409
  11. Hagihara A, Miyamoto K, Furuta J, Hiraoka N, Wakazono K, Seki S, Fukushima S, Tsao MS, Sugimura T and Ushijima T.  Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers.  Oncogene, 23: 8705-8710, 2004.  PMID: 15467763
  12. Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T and Ushijima T.  Promoter methylation profiling of 30 genes in human malignant melanoma.  Cancer Sci, 95: 962-968, 2004.  PMID: 15596045

 

2003

  1. Abe M, Yamashita S, Kuramoto T, Hirayama Y, Tsukamoto T, Ohta T, Tatematsu M, Ohki M, Takato T, Sugimura T, and Ushijima T.  Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.  Carcinogenesis, 24: 861-867, 2003.  PMID: 12771029
  2. Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, Oishi S, Fukui H, Sugimura T, and Ushijima T.  Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.  Oncology, 64: 380-388, 2003.  PMID: 12759536
  3. Huang H, Ushijima T, Nagao M, Sugimura T, and Ohgaki H.  beta-Catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.  Cancer Lett, 198: 29-35, 2003.  PMID: 12893427
  4. Kaneda A, Takai D, Kaminishi M, Okochi E, and Ushijima T.  Methylation-sensitive representational difference analysis and its application to cancer research.  Ann N Y Acad Sci, 983: 131-141, 2003.  PMID: 12724218
  5. Miyamoto K, Asada K, Fukutomi T, Okochi E, Yagi Y, Hasegawa T, Asahara T, Sugimura T, and Ushijima T.  Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.  Oncogene, 22: 274-280, 2003.  PMID: 12527896
  6. Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Chao J, Ushijima T, and Shirai T.  Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.  Prostate, 54: 187-193, 2003.  PMID: 12518323
  7. Tsukamoto T, Yamamoto M, Ogasawara N, Ushijima T, Nomoto T, Fujita H, Matsushima T, Nozaki K, Cao X, and Tatematsu M.  beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas.  Cancer Sci, 94: 1046-1051, 2003.  PMID: 14662019
  8. Ushijima T, Watanabe N, Okochi E, Kaneda A, Sugimura T, and Miyamoto K.  Fidelity of the methylation pattern and its variation in the genome.  Genome Res, 13: 868-874, 2003.  PMID: 12727906
  9. Yamashita S, Nomoto T, Ohta T, Ohki M, Sugimura T, and Ushijima T.  Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays.  Mamm Genome, 14: 845-852, 2003.  PMID: 14724737

 

2002

  1. Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T and Ushijima T.  Cloning of the 5’ upstream region of the rat p16 gene and its role in silencing.  Jpn J Cancer Res, 93: 1100-1106, 2002.  PMID: 12417039
  2. Kuwamura M, Maeda M, Kuramoto T, Kitada K, Kanehara T, Moriyama M, Nakane Y, Yamate J, Ushijima T, Kotani T and Serikawa T.  The myelin vacuolation (mv) rat with a null mutation in the attractin gene.  Laboratory Investigation, 82: 1279-1286, 2002.  PMID: 12379762
  3. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T and Ushijima T.  Identification of silencing of nine genes in human gastric cancers.  Cancer Res, 62: 6645-6650, 2002.  PMID: 12438262
  4. Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T and Ushijima T.  Reduced expression of the insulin-induced protein 1 and p41 Arp02月03日 complex genes in human gastric cancers.  Int J Cancer, 100: 57-62, 2002.  PMID: 12115587
  5. Okochi E, Miyamoto K, Wakazono K, Shima H, Sugimura T and Ushijima T.  Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.  Mol Carcino, 34: 211-218, 2002.  PMID: 12203372
  6. Okochi E, Watanabe N, Sugimura T and Ushijima T.  Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?  Mutat Res, 101: 506-507, 2002.  PMID: 12351149
  7. Okochi E, Ichimura S, Sugimura T and Ushijima T.  The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions.  Jpn J Cancer Res, 93: 501-506, 2002.  PMID: 12036445
  8. Yamashita S, Furumoto K, Nobukiyo A, Kamohara M, Ushijima T and Furukawa T.  Mapping of a gene responsible for cataract formation and its modifier in the UPL rat.  Invest Ophthalmol Vis Sci, 43: 3153-3159, 2002.  PMID: 12356818
  9. Yamashita S, Wakazono K, Sugimura T and Ushijima T.  Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility.  Carcinogenesis, 23: 923-928, 2002.  PMID: 12082013
  10. Li QL, Ito K, Sakakura C, Fukamachi H, Chi XZ, Lee KY, Lee CW, Han SB, Kim HM, Kim WJ, Inoue K, Nomura S, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawwa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC and Ito Y.  Causal relationship between the loss of RUNX3 expression and gastric cancer.  Cell, 109: 113-124, 2002.  PMID: 11955451
  11. Nagao M, Ushijima T, Watanabe N, Okochi E, Ochiai M, Nakagama H and Sugimura T.  Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats.  Environ Mol Mutagen, 39: 158-164, 2002.  PMID: 11921184
  12. Miyamoto K, Fukutomi T, Asada K, Wakazono K, Tsuda H, Asahara T, Sugimura T and Ushijima T.  Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers.  Jpn J Clin Oncol, 32: 79-84, 2002.  PMID: 11956301
  13. Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T and Shirai T.  Down-regulation of Lsm1 is involved in human prostate cancer progression.  Br J Cancer, 86: 940-946, 2002.  PMID: 11953827
  14. Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Nishiyama N, Fujita T, Inoue T, Hioki T, Sugimura Y, Ushijima T and Shirai T.  Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers.  Prostate, 50: 154-161, 2002.  PMID: 11813207
  15. Kuramoto T, Nomoto T, Fujiwara A, Mizutani M, Sugimura T and Ushijima T.  Insertional mutation of the Attractin gene in the black tremor hamster.  Mamm Genome, 13: 36-40, 2002.  PMID: 11773967
  16. Kuramoto T, Morimura K, Yamashita S, Okochi E, Watanabe N, Ohta T, Ohki M, Fukushima S, Sugimura T and Ushijima T.  Etiology-specific gene expression profiles in rat mammary carcinomas.  Cancer Res, 62: 3592-3597, 2002.  PMID: 12097258

 

2001

  1. Watanabe N, Okochi E, Mochizuki M, Sugimura T and Ushijima T.  The presence of single nucleotide instability in human breast cancer cell lines.  Cancer Res, 61: 7739-7742, 2001.  PMID: 11691786
  2. Takai D, Yagi Y, Wakazono K, Ohishi N, Morita H, Sugimura T and Ushijima T.  Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis.  Oncogene, 20: 7505-7513, 2001.  PMID: 11709722
  3. Nagao M, Ochiai M, Okochi E, Ushijima T and Sugimura TlacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.  Mutat Res, 477: 119-124, 2001.  PMID: 11376693
  4. Spinola M, Nomoto T, Manenti G, Falvella FS, Brega Massone PP, Conti B, Cataldo I, Valagussa P, Incarbone M, Miyamoto K, Ushijima T and Dragani TA.  Linkage disequilibrium pattern in the L-myc gene in Italian and Japanese non-small-cell lung-cancer patients.  Int J Cancer, 95: 329-331, 2001.  PMID: 11494234
  5. Kuramoto T, Nomoto T, Sugimura T and Ushijima T.  Linkage mapping of the rat Interleukin 1 Receptor Antagonist gene on chromosome 3.  Exp Anim, 12: 355-357, 2001.  PMID: 11515103
  6. Kuramoto T, Nomoto T, Sugimura T and Ushijima T.  Cloning of the rat agouti gene and identification of the rat nonagouti mutation.  Mamm Genome, 12: 469-471, 2001.  PMID: 11353396
  7. Watanabe N, Okochi E, Hirayama Y, Shimada Y, Yanagihara K, Yoshida MC, Takahashi S, Mochizuki M, Sugimura T, Nagao M and Ushijima T.  Single nucleotide instability without microsatellite instability in rat mammary carcinomas.  Cancer Res, 61: 2632-2640, 2001.  PMID: 11289141
  8. Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T and Serikawa T.  Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.  Proc Natl Acad Sci USA, 98: 559-564, 2001.  PMID: 11209055
  9. Niwa T, Yamashita S, Nakamura A, Shiojiri N and Ushijima T.  Isolation of a genetic marker linked to the Bh gene by genetically directed representational difference analysis of closed colony Japanese quails.  Zoolog Sci, 18: 37-41, 2001.

 

2000

  1. Yamashita S, Yoshida Y, Kurahashi A, Sugimura T and Ushijima T.  Construction of a high-throughput rat genetic mapping system with 466 arbitrarily primed-representational difference analysis markers.  Mamm Genome, 11: 982-988, 2000.  PMID: 11063254
  2. Honda H, Ushijima T, Wakazono K, Oda H, Tanaka Y, Aizawa S-i, Ishikawa T, Yazaki Y and Hirai H.  Acquired loss of p53 induced blastic transformation in p210bcr/abl-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.  Blood, 95: 1144-1150, 2000.  PMID: 10666183
  3. Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T and Nagao M.  Chromosomal mapping of genes controlling development, histological grade, depth of invasion and size of rat stomach carcinomas.  Cancer Res, 60: 1092-1096, 2000.  PMID: 10706129
  4. Ashida A, Fukutomi T, Tsuda H, Akashi-Tanaka S and Ushijima T.  Atypical medullary carcinoma of the breast with cartilaginous metaplasia in a patient with a BRCA1 germline mutation.  Jpn J Clin Oncol, 30: 30-32, 2000.  PMID: 10770566
  5. Takahashi S, Ikeda Y, Kimoto N, Okochi E, Cui L, Nagao M, Ushijima T and Shirai T.  Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue rats.  Mutat Res, 447: 275-280, 2000.  PMID: 10751611
  6. Sugimura T and Ushijima T.  Genetic and epigenetic alterations in carcinogenesis.  Mutat Res, 462: 235-246, 2000.  PMID: 10767635
  7. Stuart GR, Thorleifson E, Okochi E, Boer JGd, Ushijima T, Nagao M and Glickman BW.  Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue rats.  Mutat Res, 452: 101-121, 2000.  PMID: 10894896
  8. Higo K, Ushijima T, Oyabu A, Ye C, Yagyu S, Takahashi H and Matsuyama M.  Generation of a polymorphic marker linked to thymoma susceptibility gene of rat 1 by genetically-directed representational difference analysis.  Exp Anim, 49: 189-195, 2000.  PMID: 11109541
  9. Takai D, Yagi Y, Habib N, Sugimura T and Ushijima T.  Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis.  Jpn J Clin Oncol, 30: 306-309, 2000.  PMID: 11007163