トップページ > 2013年の刊行論文

2013年の刊行論文

Cumulated List of Papers Published in 2013

Group for Cancer Development: 1. Division of Molecular Pathology; 2. Division of Genetics; 3. Division of Familial Cancer Research; 4. Division of Multistep Carcinogenesis; 5. Division of Virology; 6. Division of Cancer Development System

Group for Research of Molecular Functions and Targets: 7. Division of Metastasis and Invasion Signaling; 8. Division of Molecular and Cellular Medicine; 9. Division of Cancer Biology; 10. Division of Cancer Differentiation; 11. Division of Hematological Malignancy

Group for Development of Molecular diagnostics and Individualized Therapy: 12. Division of Pharmacogenomics; 13. Division of Pharmacoproteomics; 14. Division of Epigenomics; 15. Division of Genome Biology; 16. Division of Cancer Genomics

Group for Translational Research: 17. Division of Cancer Pathophysiology; 18. Division of Cancer Stem Cell; 19. Division of Gene and Immune Medicine; 20. Division of Genome Stability Research; 21. Division of Chemotherapy and Clinical Research

Core Facilities for Research and Innovative Medicine: 22. Central Animal Division; 23. Central Radioisotope Division; 24. Core Facility Division

Project Group: 25. Division of Refractory Cancer Research; 26. Division of Cancer Prevention Research; 27. Division of Integrative Omics and Bioinformatics; 28. Division of Brain Tumor Translational Research

Group for Translational Research Support Core: 29. Department of Biobank Support Core; 30. Department of Clinical Pharmacology; 31. Department of Translational Research Seeds Evaluation; 32. Department of Clinical Genomics; 33. Department of Translational Oncology; 34. Department of Biomarker Evaluation; 35. Department of Bioinformatics

1. Division of Molecular Pathology

1. Chihara Y, Kanai Y, Fujimoto H, Sugano K, Kawashima K, Liang G, Jones PA, Fujimoto K, Kuniyasu H, Hirao Y. Diagnostic markers of urothelial cancer based on DNA methylation analysis. BMC Cancer, 13:275, 2013

2. Hara T, Nakanishi H, Nakagawa T, Komiyama M, Kawahara T, Manabe T, Miyake M, Arai E, Kanai Y, Fujimoto H. Ability of preoperative 3.0-Tesla magnetic resonance imaging to predict the absence of side-specific extracapsular extension of prostate cancer. Int J Urol, 20:993-999, 2013

3. Ino Y, Yamazaki-Itoh R, Oguro S, Shimada K, Kosuge T, Zavada J, Kanai Y, Hiraoka N. Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS One, 8:e55146, 2013

4. Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y, Hiraoka N. Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer, 108:914-923, 2013

5. Ishida M, Sekine S, Fukagawa T, Ohashi M, Morita S, Taniguchi H, Katai H, Tsuda H, Kushima R. Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis. Am J Surg Pathol, 37:949-959, 2013

6. Iwaya Y, Kobayashi M, Momose M, Hiraoka N, Sakai Y, Akamatsu T, Tanaka E, Ohtani H, Fukuda M, Nakayama J. High levels of FOXP3⁺ regulatory T cells in gastric MALT lymphoma predict responsiveness to Helicobacter pylori eradication. Helicobacter, 18:356-362, 2013

7. Kinoshita T, Ishii G, Hiraoka N, Hirayama S, Yamauchi C, Aokage K, Hishida T, Yoshida J, Nagai K, Ochiai A. Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma. Cancer Sci, 104:409-415, 2013

8. Kobayashi S, Tsuta K, Sekine S, Yoshida A, Sasaki N, Shibuki Y, Sakurai H, Watanabe S, Asamura H, Tsuda H. Pulmonary neuroendocrine tumors with nuclear inclusion. Pathol Res Pract, 209:574-577, 2013

9. Kondo S, Ojima H, Tsuda H, Hashimoto J, Morizane C, Ikeda M, Ueno H, Tamura K, Shimada K, Kanai Y, Okusaka T. Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma. Int J Clin Oncol, 18:207-213, 2013

10. Kushima R, Sekine S, Matsubara A, Taniguchi H, Ikegami M, Tsuda H. Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma. Pathol Int, 63:318-325, 2013

11. Makuuchi Y, Honda K, Osaka Y, Kato K, Kojima T, Daiko H, Igaki H, Ito Y, Hoshino S, Tachibana S, Watanabe T, Furuta K, Sekine S, Umaki T, Watabe Y, Miura N, Ono M, Tsuchida A, Yamada T. Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy. Cancer Sci, 104:1045-1051, 2013

12. Maruyama M, Kobayashi M, Sakai Y, Hiraoka N, Ohya A, Kageyama S, Tanaka E, Nakayama J, Morohoshi T. Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis. Pancreas, 42:53-59, 2013

13. Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, Kanai Y. Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. J Pathol, 229:579-587, 2013

14. Matsubara A, Sekine S, Yoshida M, Yoshida A, Taniguchi H, Kushima R, Tsuda H, Kanai Y. Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology, 62:657-661, 2013

15. Matsuzaki J, Suzuki H, Tsugawa H, Watanabe M, Hossain S, Arai E, Saito Y, Sekine S, Akaike T, Kanai Y, Mukaisho K, Auwerx J, Hibi T. Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis. Gastroenterology, 145:1300-1311, 2013

16. Nakagawa T, Hara T, Kawahara T, Ogata Y, Nakanishi H, Komiyama M, Arai E, Kanai Y, Fujimoto H. Prognostic risk stratification of patients with urothelial carcinoma of the bladder with recurrence after radical cystectomy. J Urol, 189:1275-1281, 2013

17. Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y. Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms. Br J Cancer, 108:951-958, 2013

18. Oguro S, Shimada K, Ino Y, Esaki M, Nara S, Kishi Y, Kosuge T, Kanai Y, Hiraoka N. Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma. Am J Surg Pathol, 37:1030-1038, 2013

19. Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima AM, Akazawa C, Watabe Y, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H. SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol, 26:1041-1050, 2013

20. Otsuka T, Morizane C, Nara S, Ueno H, Kondo S, Shimada K, Kosuge T, Ikeda M, Hiraoka N, Okusaka T. Gemcitabine in patients with intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas. Pancreas, 42:889-892, 2013

21. Saito Y, Suzuki H, Imaeda H, Matsuzaki J, Hirata K, Tsugawa H, Hibino S, Kanai Y, Saito H, Hibi T. The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. Int J Cancer, 132:1751-1760, 2013

22. Sato T, Arai E, Kohno T, Tsuta K, Watanabe S, Soejima K, Betsuyaku T, Kanai Y. DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma. PLoS One, 8:e59444, 2013

23. Sekiguchi M, Matsuda T, Sekine S, Sakamoto T, Nakajima T, Kushima R, Akasu T, Saito Y. Repeatedly recurrent colon cancer involving the appendiceal orifice after endoscopic piecemeal mucosal resection: a case report. Korean J Gastroenterol, 61:286-289, 2013

24. Sekiguchi M, Sekine S, Oda I, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Tsuda H, Kushima R, Saito Y. Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer. J Gastroenterol, 48:706-712, 2013

25. Sekiguchi M, Suzuki H, Oda I, Abe S, Nonaka S, Yoshinaga S, Taniguchi H, Sekine S, Kushima R, Saito Y. Favorable long-term outcomes of endoscopic submucosal dissection for locally recurrent early gastric cancer after endoscopic resection. Endoscopy, 45:708-713, 2013

26. Yamada M, Oda I, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Kushima R, Saito Y, Gotoda T. Long-term outcome of endoscopic resection of superficial adenocarcinoma of the esophagogastric junction. Endoscopy, 45:992-996, 2013

27. Yamada M, Sekine S, Matsuda T. Dome-type carcinoma of the colon masquerading a submucosal tumor. Clin Gastroenterol Hepatol, 11:A30, 2013

28. Yamanoi K, Fukuma M, Uchida H, Kushima R, Yamazaki K, Katai H, Kanai Y, Sakamoto M. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. Pathol Int, 63:13-19, 2013

29. Yamazaki H, Mori T, Yazawa M, Maeshima AM, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y. Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis. Lab Invest, 93:1331-1338, 2013

30. Yazawa M, Mori T, Kishi K. A comparison of malignant bone treatments for reuse. Surg Sci, 4:49-52, 2013

31. Yoshida N, Esaki M, Kishi Y, Shimada K, Ojima H, Kanai Y, Hiraoka N. Bile duct carcinoma involving the common channel associated with pancreaticobiliary maljunction shows an extension pattern similar to ductal carcinoma of the pancreas. Pathol Int, 63:415-418, 2013

2. Division of Genetics

32. Aoyagi K, Tamaoki M, Nishumura T, Sasaki H. Technical considerations for analyzing EMT-MET data from surgical samples. Cancer Lett, 341:105-110, 2013

33. Fujita T, Yanagihara K, Takeshita F, Aoyagi K, Nishimura T, Takigahira M, Chiwaki F, Fukagawa T, Katai H, Ochiya T, Sakamoto H, Konno H, Yoshida T, Sasaki H. Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice. Cancer Sci, 104:214-222, 2013

34. Ishii H, Sasaki H, Aoyagi K, Yamazaki T. Classification of gastric cancer subtypes using ICA, MLR and Bayesian network. Stud Health Technol Inform, 192:1014, 2013

35. Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K. Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells. J Carcinog, 12:4, 2013

36. Saeki N, Ono H, Sakamoto H, Yoshida T. Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci, 104:1-8, 2013

37. Shiba N, Ichikawa H, Taki T, Park MJ, Jo A, Mitani S, Kobayashi T, Shimada A, Sotomatsu M, Arakawa H, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y. NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Genes Chromosomes Cancer, 52:683-693, 2013

38. Takahashi H, Kaniwa N, Saito Y, Sai K, Hamaguchi T, Shirao K, Shimada Y, Matsumura Y, Ohtsu A, Yoshino T, Takahashi A, Odaka Y, Okuyama M, Sawada J, Sakamoto H, Yoshida T. Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data. J Biosci Bioeng, 116:768-773, 2013

39. Takahashi H, Nakayama R, Hayashi S, Nemoto T, Murase Y, Nomura K, Takahashi T, Kubo K, Marui S, Yasuhara K, Nakamura T, Sueo T, Takahashi A, Tsutsumiuchi K, Ohta T, Kawai A, Sugita S, Yamamoto S, Kobayashi T, Honda H, Yoshida T, Hasegawa T. Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses. PLoS One, 8:e78250, 2013

3. Division of Familial Cancer Research

40. Horiuchi K, Okamoto T, Iihara M, Tsukada T. An analysis of genotype-phenotype correlations and survival outcomes in patients with primary hyperparathyroidism caused by multiple endocrine neoplasia type 1: the experience at a single institution. Surg Today, 43:894-899, 2013

4. Division of Multistep Carcinogenesis

5. Division of Virology

41. Kasahara K, Goto H, Izawa I, Kiyono T, Watanabe N, Elowe S, Nigg EA, Inagaki M. PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition. Nat Commun, 4:1882, 2013

42. Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol, 115:780-788, 2013

43. Mitsuishi T, Ohsawa I, Kato T, Egawa N, Kiyono T. Molecular cloning and characterisation of a novel type of human papillomavirus 160 isolated from a flat wart of an immunocompetent patient. PLoS One, 8:e79592, 2013

44. Nakamura M, Takakura M, Fujii R, Maida Y, Bono Y, Mizumoto Y, Zhang X, Kiyono T, Kyo S. The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth. Cancer Lett, 336:68-75, 2013

45. Teng Z, Yoshida T, Okabe M, Toda A, Higuchi O, Nogami M, Yoneda N, Zhou K, Kyo S, Kiyono T, Nikaido T. Establishment of immortalized human amniotic mesenchymal stem cells. Cell Transplant, 22:267-278, 2013

46. Tokuda N, Numata S, Li X, Nomura T, Takizawa M, Kondo Y, Yamashita Y, Hashimoto N, Kiyono T, Urano T, Furukawa K, Furukawa K. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Glycobiology, 23:1175-1183, 2013

47. Unno J, Takagi M, Piao J, Sugimoto M, Honda F, Maeda D, Masutani M, Kiyono T, Watanabe F, Morio T, Teraoka H, Mizutani S. Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Sci, 104:703-710, 2013

48. Yugawa T, Nishino K, Ohno SI, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T. Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Mol Cell Biol, 33:4434-4447, 2013

49. Zhou K, Koike C, Yoshida T, Okabe M, Fathy M, Kyo S, Kiyono T, Saito S, Nikaido T. Establishment and characterization of immortalized human amniotic epithelial cells. Cell Reprogram, 15:55-67, 2013

6. Division of Cancer Development System

50. Akamoto S, Noge S, Uemura J, Maeda N, Ohshima M, Kashiwagi H, Yamamoto N, Fujiwara M, Yachida S, Takama T, Hagiike M, Okano K, Usuki H, Suzuki Y. Extraperitoneal colostomy in laparoscopic abdominoperineal resection using a laparoscopic retractor. Surg Today, 43:580-582, 2013

51. Fujita T, Asano Y, Ohtsuka J, Takada Y, Saito K, Ohki R, Fujii H. Identification of telomere-associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP). Sci Rep, 3:3171, 2013

52. Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi RU, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I. Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system. PeerJ, 1:e230, 2013

53. Ishino K, Mutoh M, Totsuka Y, Nakagama H. Metabolic syndrome: A novel high-risk state for colorectal cancer. Cancer Lett, 334:56-61, 2013

54. Kato T, Totsuka Y, Hasei T, Watanabe T, Wakabayashi K, Kinae N, Masuda S. In vivo examination of the genotoxicity of the urban air and surface soil pollutant, 3,6-dinitrobenzo[e]pyrene, with intraperitoneal and intratracheal administration. Environ Toxicol, 28:588-594, 2013

55. Kawanishi M, Ogo S, Ikemoto M, Totsuka Y, Ishino K, Wakabayashi K, Yagi T. Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells. J Toxicol Sci, 38:503-511, 2013

56. Lin Y, Totsuka Y, He Y, Kikuchi S, Qiao Y, Ueda J, Wei W, Inoue M, Tanaka H. Epidemiology of esophageal cancer in Japan and China. J Epidemiol, 23:233-242, 2013

57. Nakano T, Matsushima-Hibiya Y, Yamamoto M, Takahashi-Nakaguchi A, Fukuda H, Ono M, Takamura-Enya T, Kinashi H, Totsuka Y. ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor. Toxicon, 63:55-63, 2013

58. Ohata H, Miyazaki M, Otomo R, Matsushima-Hibiya Y, Otsubo C, Nagase T, Arakawa H, Yokota J, Nakagama H, Taya Y, Enari M. NuMA is required for the selective induction of p53 target genes. Mol Cell Biol, 33:2447-2457, 2013

59. Okano K, Asano E, Oshima M, Yamamoto N, Yachida S, Nishizawa Y, Akamoto S, Fujiwara M, Deguchi A, Mori H, Masaki T, Suzuki Y. Omental flap wrapping with fixation to the cut surface of the liver for reducing delayed gastric emptying after left-sided hepatectomy. Surg Today, 43:1425-1432, 2013

60. Okano K, Oshima M, Kakinoki K, Yamamoto N, Akamoto S, Yachida S, Hagiike M, Kamada H, Masaki T, Suzuki Y. Pancreatic thickness as a predictive factor for postoperative pancreatic fistula after distal pancreatectomy using an endopath stapler. Surg Today, 43:141-147, 2013

61. Okano K, Oshima M, Yamamoto N, Yachida S, Suzuki Y. Education and imaging. Hepatobiliary and pancreatic: intrahepatic biliary cystadenocarcinoma. J Gastroenterol Hepatol, 28:753, 2013

62. Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y. Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene, 32:4903-4912, 2013

63. Onuma K, Ochiai M, Orihashi K, Takahashi M, Imai T, Nakagama H, Hippo Y. Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A, 110:11127-11132, 2013

64. Oshima M, Okano K, Muraki S, Haba R, Maeba T, Suzuki Y, Yachida S. Immunohistochemically detected expression of 3 major genes (CDKN2A/p16, TP53, and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer. Ann Surg, 258:336-346, 2013

65. Takahashi-Nakaguchi A, Matsumoto Y, Yamamoto M, Iwabuchi K, Totsuka Y, Sugimura T, Wakabayashi K. Demonstration of cytotoxicity against wasps by pierisin-1: a possible defense factor in the cabbage white butterfly. PLoS One, 8:e60539, 2013

66. Takai E, Tsukimoto M, Kojima S. TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1. PLoS One, 8:e76346, 2013

67. Watanabe M, Yoneda M, Morohashi A, Hori Y, Okamoto D, Sato A, Kurioka D, Nittami T, Hirokawa Y, Shiraishi T, Kawai K, Kasai H, Totsuka Y. Effects of Fe₃O₄ magnetic nanoparticles on A549 cells. Int J Mol Sci, 14:15546-15560, 2013

68. Yachida S, Iacobuzio-Donahue CA. Evolution and dynamics of pancreatic cancer progression. Oncogene, 32:5253-5260, 2013

7. Division of Metastasis and Invasion Signaling

69. Kasuga M, Ueki K, Tajima N, Noda M, Ohashi K, Noto H, Goto A, Ogawa W, Sakai R, Tsugane S, Hamajima N, Nakagama H, Tajima K, Miyazono K, Imai K. Report of the Japan Diabetes Society/Japanese Cancer Association joint committee on diabetes and cancer. Cancer Sci, 104:965-976, 2013

70. Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R. CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells. Mol Cancer Res, 11:628-637, 2013

71. Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M. Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes. Cancer Sci, 104:1189-1197, 2013

72. Uekita T, Fujii S, Miyazawa Y, Hashiguchi A, Abe H, Sakamoto M, Sakai R. Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells. Cancer Sci, 104:865-870, 2013

8. Division of Molecular and Cellular Medicine

73. Fujita Y, Takeshita F, Kuwano K, Ochiya T. RNAi therapeutic platforms for lung diseases. Pharmaceuticals, 6:223-250, 2013

74. Fujita Y, Takeshita F, Mizutani T, Ohgi T, Kuwano K, Ochiya T. A novel platform to enable inhaled naked RNAi medicine for lung cancer. Sci Rep, 3:3325, 2013

75. Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T. Cancer stem cells of sarcoma. In: Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T (eds), Role of cancer stem cells in cancer biology and therapy. USA, CRC Press, pp 23-78, 2013

76. Gailhouste L, Gomez-Santos L, Hagiwara K, Hatada I, Kitagawa N, Kawaharada K, Thirion M, Kosaka N, Takahashi RU, Shibata T, Miyajima A, Ochiya T. miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology, 58:1153-1165, 2013

77. Gailhouste L, Gomez-Santos L, Ochiya T. Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer. Front Biosci, 18:199-223, 2013

78. Gailhouste L, Ochiya T. Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol histopathol, 28:437-451, 2013

79. Gailhouste L, Ochiya T. MicroRNAs: new tools to tackle liver cancer progression. Cancer Diagnostics, pp 12-14, 2013

80. Hagiwara K, Gailhouste L, Kosaka N, Ochiya T. The emerging function of natural products as regulators of miRNAs in human diseases. In: Sahu SC (ed), microRNAs in Toxicology and Medicine. U.K., John Wiley & Sons, Ltd., pp 237-248, 2013

81. Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K, Seki A, Komura T, Honda M, Wada T, Furuichi K, Ochiya T, Kaneko S. Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4⁺ T-cell suppression. Eur J Immunol, 43:2956-2968, 2013

82. Hong J, He H, Bui P, Ryba-White B, Rumi MAK, Soares MJ, Dutta D, Paul S, Kawamata M, Ochiya T, Ying QL, Rajanahalli P, Weiss ML. A focused microarray for screening rat embryonic stem cell lines. Stem Cells Dev, 22:431-443, 2013

83. Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi RU, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I. Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system. PeerJ, 1:e230, 2013

84. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest, 123:4627-4640, 2013

85. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Purification of RNA from milk whey. Methods Mol Biol, 1024:191-201, 2013

86. Kato K, Kobayashi M, Hanamura N, Akagi T, Kosaka N, Ochiya T, Ichiki T. Electrokinetic evaluation of individual exosomes by on-chip microcapillary electrophoresis with laser dark-field microscopy. Jpn J Appl Phys, 52:06GK10-1-06GK10, 2013

87. Katsuda T, Kojima N, Ochiya T, Sakai Y. Biliary epithelial cells play an essential role in the reconstruction of hepatic tissue with a functional bile ductular network. Tissue Eng Part A, 19:2402-2411, 2013

88. Katsuda T, Kosaka N, Takeshita F, Ochiya T. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics, 13:1637-1653, 2013

89. Katsuda T, Teratani T, Chowdhury MM, Ochiya T, Sakai Y. Hypoxia efficiently induces differentiation of mouse embryonic stem cells into endodermal and hepatic progenitor cells. Biochem Eng J, 74:95-101, 2013

90. Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, Takeshita F, Sakai Y, Kuroda M, Ochiya T. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep, 3:1197, 2013

91. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem, 288:10849-10859, 2013

92. Kosaka N, Takeshita F, Yoshioka Y, Hagiwara K, Katsuda T, Ono M, Ochiya T. Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment. Adv Drug Deliv Rev, 65:376-382, 2013

93. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Katsuda T, Ochiya T. Trash or treasure: extracellular microRNAs and cell-to-cell communication. Front Genet, 4:173, 2013

94. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Ochiya T. Functional analysis of exosomal microRNA in cell-cell communication research. In: (ed), Circulating MicroRNAs - Methods and Protocols, Methods in Molecular Biology Volume 1024. Germany, Springer, pp 1-10, 2013

95. Morita S, Horii T, Kimura M, Ochiya T, Tajima S, Hatada I. miR-29 represses the activities of DNA methyltransferases and DNA demethylases. Int J Mol Sci, 14:14647-14658, 2013

96. Nakagawa SI, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M. Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One, 8:e59611, 2013

97. Ochiya T, Lotvall J. Exosome as a novel shuttle for innovation. preface. Adv Drug Deliv Rev, 65:v, 2013

98. Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther, 21:185-191, 2013

99. Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, Honda M, Usui S, Takamura M, Takamura T, Ochiya T, Furuichi K, Wada T, Kaneko S. Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology, 58:1133-1142, 2013

100. Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev, 65:383-390, 2013

101. Takahashi RU, Takeshita F, Honma K, Ono M, Kato K, Ochiya T. Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep, 3:2474, 2013

102. Thirion M, Ochiya T. Extracellular microRNAs as potential biomarkers and therapeutic tools in cancer. In: Lopez-Camarillo C, Marchat LA (eds), MicroRNAs in Cancer. USA, CRC Press, pp 308-332, 2013

103. Thirion M, Ochiya T. Roles of microRNAs in the hepatitis B virus infection and related diseases. Viruses, 5:2690-2703, 2013

104. Uchino K, Ochiya T, Takeshita F. RNAi therapeutics and applications of microRNAs in cancer treatment. Jpn J Clin Oncol, 43:596-607, 2013

105. Uchino K, Takeshita F, Takahashi RU, Kosaka N, Fujiwara K, Naruoka H, Sonoke S, Yano J, Sasaki H, Nozawa S, Yoshiike M, Kitajima K, Chikaraishi T, Ochiya T. Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression. Mol Ther, 21:610-619, 2013

106. Yoshioka Y, Konishi Y, Kosaka N, Katsuda T, Kato T, Ochiya T. Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles, 2:20424, 2013

9. Division of Cancer Biology

10. Division of Cancer Differentiation

11. Division of Hematological Malignancy

107. Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A, 110:4339-4344, 2013

108. Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A, 110:3895-3900, 2013

109. Shima Y, Honma Y, Kitabayashi I. PML-RARα and its phosphorylation regulate pml oligomerization and HIPK2 stability. Cancer Res, 73:4278-4288, 2013

110. Shimizu K, Yamagata K, Kurokawa M, Mizutani S, Tsunematsu Y, Kitabayashi I. Roles of AML1/RUNX1 in T-cell malignancy induced by loss of p53. Cancer Sci, 104:1033-1038, 2013

111. Yokoyama A, Ficara F, Murphy MJ, Meisel C, Hatanaka C, Kitabayashi I, Cleary ML. MLL becomes functional through intra-molecular interaction not by proteolytic processing. PLoS One, 8:e73649, 2013

12. Division of Pharmacogenomics

13. Division of Pharmacoproteomics

112. Arai K, Sakamoto R, Kubota D, Kondo T. Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system. Proteomics, 13:2351-2360, 2013

113. Haga A, Ogawara Y, Kubota D, Kitabayashi I, Murakami Y, Kondo T. Interactomic approach for evaluating nucleophosmin-binding proteins as biomarkers for Ewing's sarcoma. Electrophoresis, 34:1670-1678, 2013

114. Hasegawa T, Asanuma H, Ogino J, Hirohashi Y, Shinomura Y, Iwaki H, Kikuchi H, Kondo T. Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. Hum Pathol, 44:1271-1277, 2013

115. Hosoya N, Sakumoto M, Nakamura Y, Narisawa T, Bilim V, Motoyama T, Tomita Y, Kondo T. Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma. Biochim Biophys Acta, 1834:2630-2639, 2013

116. Huang C, Wang Y, Liu S, Ding G, Liu W, Zhou J, Kuang M, Ji Y, Kondo T, Fan J. Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma. J Proteome Res, 12:1838-1846, 2013

117. Ichikawa H, Kanda T, Kosugi SI, Kawachi Y, Sasaki H, Wakai T, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer. J Proteome Res, 12:3780-3791, 2013

118. Kimura K, Ojima H, Kubota D, Sakumoto M, Nakamura Y, Tomonaga T, Kosuge T, Kondo T. Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma. J Proteomics, 78:362-373, 2013

119. Kondo T, Suehara Y, Kikuta K, Kubota D, Tajima T, Mukaihara K, Ichikawa H, Kawai A. Proteomic approach toward personalized sarcoma treatment: lessons from prognostic biomarker discovery in gastrointestinal stromal tumor. Proteomics Clin Appl, 7:70-78, 2013

120. Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T. The prognostic value of pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol, 43:669-675, 2013

121. Kubota D, Mukaihara K, Yoshida A, Tsuda H, Kawai A, Kondo T. Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma. J Proteomics, 91:393-404, 2013

122. Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T. Gene Expression Network Analysis of ETV1 Reveals KCTD10 as a Novel Prognostic Biomarker in Gastrointestinal Stromal Tumor. PLoS One, 8:e73896, 2013

123. Sugihara Y, Taniguchi H, Kushima R, Tsuda H, Kubota D, Ichikawa H, Fujita S, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis reveal proteomic intra-tumor heterogeneity in colorectal cancer. J Proteomics, 78:134-147, 2013

124. Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T, Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N. Integrated view of the human chromosome X-centric proteome project. J Proteome Res, 12:58-61, 2013

125. Yonemori H, Kubota D, Taniguchi H, Tsuda H, Fujita S, Murakami Y, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis with alkaline isoelectric point immobiline gel reveals proteomic intra-tumor heterogeneity in colorectal cancer. EuPA Open Proteomics, 1:17-29, 2013

14. Division of Epigenomics

126. Asada K, Abe M, Ushijima T. Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas. J Hum Genet, 58:428-433, 2013

127. Asada K, Ando T, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, Yoshida T, Miyamoto K, Enomoto S, Ichinose M, Tsukamoto T, Ito S, Tatematsu M, Sugiyama T, Ushijima T. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Oncogene, 32:2140-2149, 2013

128. Asada K, Watanabe N, Nakamura Y, Ohira M, Westermann F, Schwab M, Nakagawara A, Ushijima T. Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas. Jpn J Clin Oncol, 43:641-645, 2013

129. Hattori N, Niwa T, Kimura K, Helin K, Ushijima T. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res, 41:7231-7239, 2013

130. Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development, 140:66-75, 2013

131. Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M. Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain, 136:828-843, 2013

132. Ito Y, Yamada Y, Asada K, Ushijima T, Iwasa S, Kato K, Hamaguchi T, Shimada Y. EGFR L2 domain mutation is not correlated with resistance to cetuximab in metastatic colorectal cancer patients. J Cancer Res Clin Oncol, 139:1391-1396, 2013

133. Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH, Ushijima T. Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett, 330:33-40, 2013

134. Niwa T, Toyoda T, Tsukamoto T, Mori A, Tatematsu M, Ushijima T. Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent. Cancer Prev Res (Phila), 6:263-270, 2013

135. Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T. Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett, 340:141-147, 2013

136. Suzuki T, Yamashita S, Ushijima T, Takumi S, Sano T, Michikawa T, Nohara K. Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors. Cancer Sci, 104:1575-1585, 2013

137. Takahashi T, Matsuda Y, Yamashita S, Hattori N, Kushima R, Lee YC, Igaki H, Tachimori Y, Nagino M, Ushijima T. Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation. PLoS One, 8:e82302, 2013

138. Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ushijima T, Ichinose M. Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. Gastric Cancer, 16:488-497, 2013

139. Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A. Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression. J Clin Invest, 123:2935-2947, 2013

15. Division of Genome Biology

140. Akagi I, Okayama H, Schetter AJ, Robles AI, Kohno T, Bowman ED, Kazandjian D, Welsh JA, Oue N, Saito M, Miyashita M, Uchida E, Takizawa T, Takenoshita S, Skaug V, Mollerup S, Haugen A, Yokota J, Harris CC. Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma. Cancer Res, 73:3821-3832, 2013

141. Iwakawa R, Takenaka M, Kohno T, Shimada Y, Totoki Y, Shibata T, Tsuta K, Nishikawa R, Noguchi M, Sato-Otsubo A, Ogawa S, Yokota J. Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer. Genes Chromosomes Cancer, 52:802-816, 2013

142. Kohno T, Tsuta K, Tsuchihara K, Nakaoku T, Yoh K, Goto K. RET fusion gene: translation to personalized lung cancer therapy. Cancer Sci, 104:1396-1400, 2013

143. Matsuura S, Shinmura K, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, Funai K, Kohno T, Suda T, Sugimura H. CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. Oncol Rep, 30:1675-1680, 2013

144. Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis, 34:2486-2497, 2013

145. Oike T, Ogiwara H, Nakano T, Yokota J, Kohno T. Inactivating mutations in SWI/SNF chromatin remodeling genes in human cancer. Jpn J Clin Oncol, 43:849-855, 2013

146. Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T. A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1. Cancer Res, 73:5508-5518, 2013

147. Suzuki M, Makinoshima H, Matsumoto S, Suzuki A, Mimaki S, Matsushima K, Yoh K, Goto K, Suzuki Y, Ishii G, Ochiai A, Tsuta K, Shibata T, Kohno T, Esumi H, Tsuchihara K. Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo. Cancer Sci, 104:896-903, 2013

148. Yoshida A, Kohno T, Tsuta K, Wakai S, Arai Y, Shimada Y, Asamura H, Furuta K, Shibata T, Tsuda H. ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases. Am J Surg Pathol, 37:554-562, 2013

16. Division of Cancer Genomics

149. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Borresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjord JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinsk M, Jager N, Jones DTW, Jones D, Knappskog S, Kool M, Lakhani SR, Lopez-Otin C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt ANJ, Valdes-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR; Australian Pancreatic Cancer Genome Initiative; ICGC Breast Cancer Consortium; ICGC MMML-Seq Consortium; ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR. Signatures of mutational processes in human cancer. Nature, 500:415-421, 2013

150. Arai Y, Totoki Y, Takahashi H, Nakamura H, Hama N, Kohno T, Tsuta K, Yoshida A, Asamura H, Mutoh M, Hosoda F, Tsuda H, Shibata T. Mouse model for ROS1-rearranged lung cancer. PLoS One, 8:e56010, 2013

151. Gonzalez-Perez A, Mustonen V, Reva B, Ritchie GRS, Creixell P, Karchin R, Vazquez M, Fink JL, Kassahn KS, Pearson JV, Bader GD, Boutros PC, Muthuswamy L, Ouellette BFF, Reimand J, Linding R, Shibata T, Valencia A, Butler A, Dronov S, Flicek P, Shannon NB, Carter H, Ding L, Sander C, Stuart JM, Stein LD, Lopez-Bigas N. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods, 10:723-729, 2013

152. Hasebe T, Iwasaki M, Hojo T, Shibata T, Kinoshita T, Tsuda H. Histological factors for accurately predicting first locoregional recurrence of invasive ductal carcinoma of the breast. Cancer Sci, 104:1252-1261, 2013

153. Ichikawa M, Arai Y, Haruta M, Furukawa S, Ariga T, Kajii T, Kaneko Y. Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor. Genes Chromosomes Cancer, 52:274-286, 2013

154. Kitagawa N, Ojima H, Shirakihara T, Shimizu H, Kokubu A, Urushidate T, Totoki Y, Kosuge T, Miyagawa S, Shibata T. Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. Cancer Sci, 104:543-551, 2013

155. Kobayashi S, Totoki Y, Soma M, Matsumoto K, Fujihara Y, Toyoda A, Sakaki Y, Okabe M, Ishino F. Identification of an imprinted gene cluster in the X-inactivation center. PLoS One, 8:e71222, 2013

156. Nakagawa H, Shibata T. Comprehensive genome sequencing of the liver cancer genome. Cancer Lett, 340:234-240, 2013

157. Nakamura H, Tsuta K, Yoshida A, Shibata T, Wakai S, Asamura H, Furuta K, Tsuda H. Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma. J Clin Pathol, 66:705-707, 2013

158. Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M. Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels. Mol Cell Biol, 33:2402-2412, 2013

159. Yoshida A, Shibata T, Tsuta K, Watanabe SI, Tsuda H. Inflammatory myofibroblastic tumour of the lung with a novel PPFIBP1-ALK fusion variant. Histopathology, 63:881-883, 2013

160. Yoshida A, Shibata T, Wakai S, Ushiku T, Tsuta K, Fukayama M, Makimoto A, Furuta K, Tsuda H. Anaplastic lymphoma kinase status in rhabdomyosarcomas. Mod Pathol, 26:772-781, 2013

17. Division of Cancer Pathophysiology

161. Minami K, Uezono Y. The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors. J Anesth, 27:284-292, 2013

162. Motoyama N, Morita K, Kitayama T, Shiraishi S, Uezono Y, Nishimura F, Kanematsu T, Dohi T. Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. Eur J Pain, 17:1156-1167, 2013

163. Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T. Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state. Addict Biol, 18:614-622, 2013

164. Sugimoto Y, Shiraishi S, Yasuda T, Hamada H, Kawamoto M. Intrathecal adrenomedullin modulates acute inflammatory pain in the rat formalin test. Neurosci Lett, 552:146-150, 2013

165. Yanagihara K, Takigahira M, Mihara K, Kubo T, Morimoto C, Morita Y, Terawaki K, Uezono Y, Seyama T. Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers. Nutr Cancer, 65:578-589, 2013

166. Yanagita T, Nemoto T, Satoh S, Yoshikawa N, Maruta T, Shiraishi S, Sugita C, Murakami M. Neuronal insulin receptor signaling: a potential target for the treatment of cognitive and mood disorders. In: Kocabasoglu N (ed), Mood Disorders. Croatia, Intech, pp 263-287, 2013

167. Yoshimura M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Ueta Y. The gene expression of the hypothalamic feeding-regulating peptides in cisplatin-induced anorexic rats. Peptides, 46:13-19, 2013

18. Division of Cancer Stem Cell

168. Maida Y, Kyo S, Lassmann T, Hayashizaki Y, Masutomi K. Off-target effect of endogenous siRNA derived from RMRP in human cells. Int J Mol Sci, 14:9305-9318, 2013

19. Division of Gene and Immune Medicine

169. Kimura J, Ono HA, Kosaka T, Nagashima Y, Hirai S, Ohno S, Aoki K, Julia D, Yamamoto M, Kunisaki C, Endo I. Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells. Cancer Sci, 104:1083-1090, 2013

170. Miura Y, Yamasaki S, Davydova J, Brown E, Aoki K, Vickers S, Yamamoto M. Infectivity-selective oncolytic adenovirus developed by high-throughput screening of adenovirus-formatted library. Mol Ther, 21:139-148, 2013

171. Suzuki K, Aida K, Miyakawa R, Narumi K, Udagawa T, Yoshida T, Ohshima Y, Aoki K. Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation. Cancer Med, 2:636-645, 2013

172. Udagawa T, Narumi K, Suzuki K, Aida K, Miyakawa R, Ikarashi Y, Makimoto A, Chikaraishi T, Yoshida T, Aoki K. Vascular endothelial growth factor-D-mediated blockade of regulatory T cells within tumors is induced by hematopoietic stem cell transplantation. J Immunol, 191:3440-3452, 2013

20. Division of Genome Stability Research

173. Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K. The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. J Biol Chem, 288:13269-13277, 2013

174. Fujimori H, Mukai H, Murakami Y, Hemberger M, Hippo Y, Masutani M. The H19 induction triggers trophoblast lineage commitment in mouse ES cells. Biochem Biophys Res Commun, 436:313-318, 2013

175. Masutani M, Fujimori H. Poly(ADP-ribosyl)ation in carcinogenesis. Mol Aspects Med, 34:1202-1216, 2013

176. Nozaki T, Fujimori H, Wang J, Suzuki H, Imai H, Watanabe M, Ohura K, Masutani M. Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment. Pathol Int, 63:408-414, 2013

177. Okajima Y, Yoshida T, Fujimori H, Wang J, Harada H, Suzuki Y, Suzuki H, Masutani M. Rapid degradation of poly(ADP-ribose) after injection into the mouse bloodstream. Biol Pharm Bull, 36:462-466, 2013

178. Osada T, Ryden AM, Masutani M. Poly(ADP-ribosylation) regulates chromatin organization through histone H3 modification and DNA methylation of the first cell cycle of mouse embryos. Biochem Biophys Res Commun, 434:15-21, 2013

179. Osawa T, Atsumi Y, Sugihara E, Saya H, Kanno M, Tashiro F, Masutani M, Yoshioka KI. Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes. Biochem Biophys Res Commun, 432:34-39, 2013

180. Shirai H, Fujimori H, Gunji A, Maeda D, Hirai T, Poetsch AR, Harada H, Yoshida T, Sasai K, Okayasu R, Masutani M. Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation. Biochem Biophys Res Commun, 435:100-106, 2013

181. Shirai H, Poetsch AR, Gunji A, Maeda D, Fujimori H, Fujihara H, Yoshida T, Ogino H, Masutani M. PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways. Cell Death Dis, 4:e656, 2013

182. Unno J, Takagi M, Piao J, Sugimoto M, Honda F, Maeda D, Masutani M, Kiyono T, Watanabe F, Morio T, Teraoka H, Mizutani S. Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Sci, 104:703-710, 2013

183. Wei L, Nakajima S, Hsieh CL, Kanno S, Masutani M, Levine AS, Yasui A, Lan L. Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose). J Cell Sci, 126:4414-4423, 2013

21. Division of Chemotherapy and Clinical Research

184. Honda K, Ono M, Shitashige M, Masuda M, Kamita M, Miura N, Yamada T. Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine. Jpn J Clin Oncol, 43:103-109, 2013

185. Makuuchi Y, Honda K, Osaka Y, Kato K, Kojima T, Daiko H, Igaki H, Ito Y, Hoshino S, Tachibana S, Watanabe T, Furuta K, Sekine S, Umaki T, Watabe Y, Miura N, Ono M, Tsuchida A, Yamada T. Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy. Cancer Sci, 104:1045-1051, 2013

186. Miyanaga A, Honda K, Tsuta K, Masuda M, Yamaguchi U, Fujii G, Miyamoto A, Shinagawa S, Miura N, Tsuda H, Sakuma T, Asamura H, Gemma A, Yamada T. Diagnostic and prognostic significance of the alternatively spliced ACTN4 variant in high-grade neuroendocrine pulmonary tumours. Ann Oncol, 24:84-90, 2013

187. Noro R, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T. Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification. Ann Oncol, 24:2594-2600, 2013

188. Noro R, Yamada T. Drifting EGFR mutation. Chin Clin Oncol, 2:3, 2013

189. Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima AM, Akazawa C, Watabe Y, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H. SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol, 26:1041-1050, 2013

190. Yoneyama T, Ohtsuki S, Ono M, Ohmine K, Uchida Y, Yamada T, Tachikawa M, Terasaki T. Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated α-fibrinogen in plasma for pancreatic cancer diagnosis. J Proteome Res, 12:753-762, 2013

22. Central Animal Division

191. Imai T, Cho YM, Takahashi M, Kitahashi T, Takami S, Nishikawa A, Ogawa K. High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncol Rep, 29:1914-1922, 2013

192. Ito K, Ishigamori R, Mutoh M, Ohta T, Imai T, Takahashi M. A^y allele promotes azoxymethane-induced colorectal carcinogenesis by macrophage migration in hyperlipidemic/diabetic KK mice. Cancer Sci, 104:835-843, 2013

193. Takahashi M, Mutoh M, Ishigamori R, Fujii G, Imai T. Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. Semin Immunopathol, 35:203-227, 2013

23. Central Radioisotope Division

24. Core Facility Division

25. Division of Refractory Cancer Research

26. Division of Cancer Prevention Research

194. Fujimoto K, Fujii G, Mutoh M, Yasunaga M, Tanaka H, Wada M. Suppression of intestinal polyp development in Apc^Min/+ mice through inhibition of P-glycoprotein using verapamil. Eur J Cancer Prev, 22:8-10, 2013

195. Hayakawa T, Mutoh M, Imai T, Tsuta K, Yanaka A, Fujii H, Yoshimoto M. SPECT/CT of lung nodules using ¹¹¹In-DOTA-c(RGDfK) in a mouse lung carcinogenesis model. Ann Nucl Med, 27:640-647, 2013

196. Iimuro M, Nakamura S, Arakawa T, Wakabayashi K, Mutoh M. Effects of dietary calcium on Helicobacter pylori-induced gastritis in Mongolian gerbils. Anticancer Res, 33:3667-3674, 2013

197. Ishikawa H, Wakabayashi K, Suzuki S, Mutoh M, Hirata K, Nakamura T, Takeyama I, Kawano A, Gondo N, Abe T, Tokudome S, Goto C, Matsuura N, Sakai T. Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. Cancer Med, 2:50-56, 2013

198. Komiya M, Fujii G, Takahashi M, Iigo M, Mutoh M. Prevention and intervention trials for colorectal cancer. Jpn J Clin Oncol, 43:685-694, 2013

199. Tamura M, Mutoh M, Fujii G, Matsui H. Involvement of mitochondrial reactive oxygen species in gastric carcinogenesis. J Gastrointest Dig Syst, 3:150, 2013

27. Division of Integrative Omics and Bioinformatics

200. Katoh M. Functional proteomics, human genetics and cancer biology of GIPC family members. Exp Mol Med, 45:e26, 2013

201. Katoh M. Functional and cancer genomics of ASXL family members. Br J Cancer, 109:299-306, 2013

202. Katoh M. Therapeutics targeting angiogenesis: Genetics and epigenetics, extracellular miRNAs and signaling networks. Int J Mol Med, 32:763-767, 2013

203. Katoh M. Great challenges in molecular medicine: toward personalized medicine. Front Cell Dev Biol, 1:1-4, 2013

204. Katoh M, Igarashi M, Fukuda H, Nakagama H, Katoh M. Cancer genetics and genomics of human FOX family genes. Cancer Lett, 328:198-206, 2013

28. Division of Brain Tumor Translational Research

205. Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, Ichimura K. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol, 126:267-276, 2013

206. Arita H, Narita Y, Takami H, Fukushima S, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Shibui S, Ichimura K. TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas. Acta Neuropathol, 126:939-941, 2013

207. Fukushima S, Narita Y, Miyakita Y, Ohno M, Takizawa T, Takusagawa Y, Mori M, Ichimura K, Tsuda H, Shibui S. A case of more than 20 years survival with glioblastoma, and development of cavernous angioma as a delayed complication of radiotherapy. Neuropathology, 33:576-581, 2013

208. Lambert SR, Witt H, Hovestadt V, Zucknick M, Kool M, Pearson DM, Korshunov A, Ryzhova M, Ichimura K, Jabado N, Fontebasso AM, Lichter P, Pfister SM, Collins VP, Jones DTW. Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma. Acta Neuropathol, 126:291-301, 2013

209. Ohno M, Narita Y, Miyakita Y, Matsushita Y, Yoshida A, Fukushima S, Ichimura K, Shibui S. Secondary glioblastomas with IDH1/2 mutations have longer glioma history from preceding lower-grade gliomas. Brain Tumor Pathol, 30:224-232, 2013

29. Department of Biobank Support Core

30. Department of Clinical Pharmacology

210. Hashiguchi Y, Hamada A, Shinohara T, Tsuchiya K, Jono H, Saito H. Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents. Biochem Biophys Res Commun, 439:221-227, 2013

211. Shimma S, Takashima Y, Hashimoto J, Yonemori K, Tamura K, Hamada A. Alternative two-step matrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency. J Mass Spectrom, 48:1285-1290, 2013

212. Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Irie A, Kawahara K, Yatsuda J, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y. Identification of promiscuous KIF20A long peptides bearing both CD4⁺ and CD8⁺ T-cell epitopes: KIF20A-specific CD4⁺ T-cell immunity in patients with malignant tumor. Clin Cancer Res, 19:4508-4520, 2013

213. Tsubata Y, Okimoto T, Miura K, Karino F, Iwamoto S, Tada M, Honda T, Hamaguchi S, Ohe M, Sutani A, Kuraki T, Hamada A, Isobe T. Phase I clinical and pharmacokinetic study of bi-weekly carboplatin/paclitaxel chemotherapy in elderly patients with advanced non-small cell lung cancer. Anticancer Res, 33:261-266, 2013

31. Department of Translational Research Seeds Evaluation

214. Katanasaka Y, Kodera Y, Kitamura Y, Morimoto T, Tamura T, Koizumi F. Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma. Mol Cancer, 12:31, 2013

215. Kondo S, Ueno H, Hosoi H, Hashimoto J, Morizane C, Koizumi F, Tamura K, Okusaka T. Clinical impact of pentraxin family expression on prognosis of pancreatic carcinoma. Br J Cancer, 109:739-746, 2013

216. Nakadate Y, Kodera Y, Kitamura Y, Tachibana T, Tamura T, Koizumi F. Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint. Biochem Biophys Res Commun, 441:793-798, 2013

217. Nishio M, Horai T, Horiike A, Nokihara H, Yamamoto N, Takahashi T, Murakami H, Koizumi F, Nishio K, Yusa W, Koyama N, Tamura T. Phase 1 study of lenvatinib combined with carboplatin and paclitaxel in patients with non-small-cell lung cancer. Br J Cancer, 109:538-544, 2013

32. Department of Clinical Genomics

33. Department of Translational Oncology

218. Aoyagi K, Tamaoki M, Nishumura T, Sasaki H. Technical considerations for analyzing EMT-MET data from surgical samples. Cancer Lett, 341:105-110, 2013

219. Ishii H, Sasaki H, Aoyagi K, Yamazaki T. Classification of gastric cancer subtypes using ICA, MLR and Bayesian network. Stud Health Technol Inform, 192:1014, 2013

220. Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K. Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells. J Carcinog, 12:4, 2013

34. Department of Biomarker Evaluation

35. Department of Bioinformatics

221. Rajaram M, Zhang J, Wang T, Li J, Kuscu C, Qi H, Kato M, Grubor V, Weil RJ, Helland A, Borrenson-Dale AL, Cho KR, Levine DA, Houghton AN, Wolchok JD, Myeroff L, Markowitz SD, Lowe SW, Zhang M, Krasnitz A, Lucito R, Mu D, Powers RS. Two distinct categories of focal deletions in cancer genomes. PLoS One, 8:e66264, 2013