トップページ > 2012年の刊行論文

2012年の刊行論文

Cumulated List of Papers Published in 2012

Group for Cancer Development and Progression: 1. Division of Molecular Pathology; 2. Division of Genetics; 3. Division of Familial Cancer Research; 4. Division of Multistep Carcinogenesis; 5. Division of Virology; 6. Division of Cancer Development System

Group for Research of Molecular Functions and Targets: 7. Division of Metastasis and Invasion Signaling; 8. Division of Molecular and Cellular Medicine; 9. Division of Cancer Biology; 10. Division of Cancer Differentiation; 11. Division of Hematological Malignancy

Group for Development of Molecular diagnostics and Individualized Therapy: 12. Division of Pharmacogenomics; 13. Division of Pharmacoproteomics; 14. Division of Epigenomics; 15. Division of Genome Biology; 16. Division of Cancer Genomics

Group for Translational Research: 17. Division of Cancer Pathophysiology; 18. Division of Cancer Stem Cell; 19. Division of Gene and Immune Medicine; 20. Division of Genome Stability Research; 21. Division of Chemotherapy and Clinical Research

Core Facilities for Research and Innovative Medicine: 22. Central Animal Division; 23. Central Radioisotope Division; 24. Core Facility Division

Project Group: 25. Division of Refractory Cancer Research; 26. Division of Cancer Prevention Research; 27. Division of Integrative Omics and Bioinformatics; 28. Division of Brain Tumor Translational Research

1. Division of Molecular Pathology

1. Arai E, Chiku S, Mori T, Gotoh M, Nakagawa T, Fujimoto H, Kanai Y. Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. Carcinogenesis, 33:1487-1493, 2012

2. Arai E, Nakagawa T, Wakai-Ushijima S, Fujimoto H, Kanai Y. DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma. Histopathology, 60:E12-18, 2012

3. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Nishimura R, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Konishi I. Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1. FEBS Lett, 586:1824-1831, 2012

4. Kanai Y, Arai E. DNA methylation alterations in human cancers. In: Tollefsbol T (ed), Epigenetics in Human Disease. Netherlands, Elsevier, pp 29-52, 2012

5. Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, Onizuka M, Sato Y, Murakami Y. Expression of a splicing variant of the CADM1 specific to small cell lung cancer. Cancer Sci, 103:1051-1057, 2012

6. Kinjo T, Taniguchi H, Kushima R, Sekine S, Oda I, Saka M, Gotoda T, Kinjo F, Fujita J, Shimoda T. Histologic and immunohistochemical analyses of α-fetoprotein - producing cancer of the stomach. Am J Surg Pathol, 36:56-65, 2012

7. Kishi Y, Shimada K, Hata S, Oguro S, Sakamoto Y, Nara S, Esaki M, Hiraoka N, Kosuge T. Definition of T3/4 and regional lymph nodes in gallbladder cancer - which is more valid, the UICC or the Japanese staging system? Ann Surg Oncol, 19:3567-3573, 2012

8. Ohtomo R, Sekine S, Taniguchi H, Tsuda H, Moriya Y, Kushima R. Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia - a human papillomavirus 18-related lesion. Pathol Int, 62:356-359, 2012

9. Ojima H. Clinicopathological significance of growth factors and their receptors as potential therapeutic targets for biliary tract carcinoma. J Hepatobiliary Pancreat Sci, 19:319-325, 2012

10. Rinkevich Y, Mori T, Sahoo D, Xu PX, Bermingham JRJ, Weissman IL. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol, 14:1251-1260, 2012

11. Schuler Y, Lee-Thedieck C, Geiger K, Kaiser T, Ino Y, Aicher WK, Klein G. Osteoblast-secreted factors enhance the expression of dysadherin and CCL2-dependent migration of renal carcinoma cells. Int J Cancer, 130:288-299, 2012

12. Tateno Y, Esaki M, Shimada K, Ojima H, Kanai Y, Hiraoka N. Morules in intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas. Pancreas, 41:651-652, 2012

13. Uno M, Shimada K, Yamamoto Y, Nara S, Esaki M, Sakamoto Y, Kosuge T, Ojima H. Periductal infiltrating type of intrahepatic cholangiocarcinoma: a rare macroscopic type without any apparent mass. Surg Today, 42:1189-1194, 2012

14. Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res, 22:208-219, 2012

15. Watanabe T, Ishihara K, Hirosue A, Watanabe S, Hino S, Ojima H, Kanai Y, Sasaki Y, Nakao M. Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol, 32:1529-1541, 2012

16. Yamada M, Sekine S, Matsuda T, Yoshida M, Taniguchi H, Kushima R, Sakamoto T, Nakajima T, Saito Y, Akasu T. Dome-type carcinoma of the colon; a rare variant of adenocarcinoma resembling a submucosal tumor - a case report. BMC Gastroenterol, 12:21, 2012

17. Yamada M, Sekine S, Ogawa R, Taniguchi H, Kushima R, Tsuda H, Kanai Y. Frequent activating GNAS mutations in villous adenoma of the colorectum. J Pathol, 228:113-118, 2012

18. Yamaguchi T, Taniguchi H, Fujita S, Sekine S, Yamamoto S, Akasu T, Kushima R, Tani T, Moriya Y, Shimoda T. Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma. Histopathology, 61:162-169, 2012

19. Yoshida A, Sekine S, Tsuta K, Fukayama M, Furuta K, Tsuda H. NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. Am J Surg Pathol, 36:993-999, 2012

20. Yoshikawa N, Shimizu N, Maruyama T, Sano M, Matsuhashi T, Fukuda K, Kataoka M, Satoh T, Ojima H, Sawai T, Morimoto C, Kuribara A, Hosono O, Tanaka H. Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. PLoS One, 7:e52522, 2012

2. Division of Genetics

21. Imoto A, Mitsunaga S, Inagaki M, Aoyagi K, Sasaki H, Ikeda M, Nakachi K, Higuchi K, Ochiai A. Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer. Int J Cancer, 131:2795-2807, 2012

22. Kondo S, Ueno H, Hashimoto J, Morizane C, Koizumi F, Okusaka T, Tamura K. Circulating endothelial cells and other angiogenesis factors in pancreatic carcinoma patients receiving gemcitabine chemotherapy. BMC Cancer, 12:268, 2012

23. Matsumoto K, Arao T, Hamaguchi T, Shimada Y, Kato K, Oda I, Taniguchi H, Koizumi F, Yanagihara K, Sasaki H, Nishio K, Yamada Y. FGFR2 gene amplification and clinicopathological features in gastric cancer. Br J Cancer, 106:727-732, 2012

24. Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K. Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors. Cancer Sci, 103:1946-1954, 2012

25. Motoi Y, Saeki M, Nishimura T, Katayama K, Kitamura N, Ichikawa H, Miyoshi H, Kaminuma O, Hiroi T. Establishment of monoclonal antibodies against a novel eosinophil-specific cell surface molecule, major facilitator super family domain containing 10. Immunol Lett, 147:80-84, 2012

26. Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki H, Yasui W. Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. PLoS One, 7:e47545, 2012

27. Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H. Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells. Pathobiology, 79:290-306, 2012

28. Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A. Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J Exp Med, 209:445-454, 2012

29. Ono H, Hiraoka N, Lee YS, Woo SM, Lee WJ, Choi IJ, Saito A, Yanagihara K, Kanai Y, Ohnami S, Chiwaki F, Sasaki H, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes Chromosomes Cancer, 51:30-41, 2012

30. Ono H, Iwasaki M, Kuchiba A, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Ohnami S, Sakamoto H, Yoshida T, Tsugane S. Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA. Cancer Sci, 103:2159-2164, 2012

31. Ono H, Yanagihara K, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen gene is expressed in islets of pancreas. Anat Cell Biol, 45:149-154, 2012

32. Oue N, Noguchi T, Anami K, Kitano S, Sakamoto N, Sentani K, Uraoka N, Aoyagi K, Yoshida T, Sasaki H, Yasui W. Cytokeratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma. Ann Surg Oncol, 19:1902-1910, 2012

33. Saeki N, Sasaki H. Gasdermin Superfamily : a novel gene family functioning in epithelial cells. In: Carrasco J, Mota M (eds), Endothelium and Epithelium: composition, functions and pathology. USA, Nova Science Publishers, Inc, pp 193?211, 2012

34. Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W. Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer. Cancer Sci, 103:1744-1750, 2012

35. Satoh Y, Mori K, Kitano K, Kitayama J, Yokota H, Sasaki H, Uozaki H, Fukayama M, Seto Y, Nagawa H, Yatomi Y, Takai D. Analysis for the combination expression of CK20, FABP1 and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer. Jpn J Clin Oncol, 42:148-152, 2012

36. Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H, Yasui W. Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis. Carcinogenesis, 33:1081-1088, 2012

37. Tada M, Ishii-Watabe A, Maekawa K, Fukushima-Uesaka H, Kurose K, Suzuki T, Kaniwa N, Sawada J, Kawasaki N, Nakajima-Eguchi T, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Okuda H, Hamaguchi T, Saito Y, Matsumura Y. Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant. Immunogenetics, 64:869-877, 2012

38. Yunokawa M, Koizumi F, Kitamura Y, Katanasaka Y, Okamoto N, Kodaira M, Yonemori K, Shimizu C, Ando M, Masutomi K, Yoshida T, Fujiwara Y, Tamura K. Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells. Cancer Sci, 103:1665-1671, 2012

3. Division of Familial Cancer Research

39. Nagamura Y, Yamazaki M, Shimazu S, Sano K, Tsukada T, Sakurai A. A novel splice site mutation of the MEN1 gene identified in a patient with primary hyperparathyroidism. Endocr J, 59:523-530, 2012

40. Nagamura Y, Yamazaki M, Shimazu S, Tsukada T, Sakurai A. Application of an intracellular stability test of a novel missense menin mutant to the diagnosis of multiple endocrine neoplasia type 1. Endocr J, 59:1093-1098, 2012

41. Shimazu S, Shimatsu A, Yamada S, Inoshita N, Nagamura Y, Usui T, Tsukada T. Resistance to dopamine agonists in prolactinoma is correlated with reduction of dopamine D₂ receptor long isoform mRNA levels. Eur J Endocrinol, 166:383-390, 2012

4. Division of Multistep Carcinogenesis

42. Iwakawa R, Okayama H, Kohno T, Sato-Otsubo A, Ogawa S, Yokota J. Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma. Genes Chromosomes Cancer, 51:462-472, 2012

43. Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, Taki T, Iwakawa R, Enari M, Taniwaki M, Yokota J, Sakoda S, Morishita K. Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer Sci, 103:782-790, 2012

44. Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, Watanabe S, Sakamoto H, Kumamoto K, Takenoshita S, Gotoh N, Mizuno H, Sarai A, Kawano S, Yamaguchi R, Miyano S, Yokota J. Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res, 72:100-111, 2012

5. Division of Virology

45. Bayasula, Iwase A, Kiyono T, Takikawa S, Goto M, Nakamura T, Nagatomo Y, Nakahara T, Kotani T, Kobayashi H, Kondo M, Manabe S, Kikkawa F. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Endocrinology, 153:2851-2860, 2012

46. Bono Y, Kyo S, Takakura M, Maida Y, Mizumoto Y, Nakamura M, Nomura K, Kiyono T, Inoue M. Creation of immortalised epithelial cells from ovarian endometrioma. Br J Cancer, 106:1205-1213, 2012

47. Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T, Lombardi PM, Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T, Krantz ID, Shirahige K. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature, 489:313-317, 2012

48. Egawa N, Kawai K, Egawa K, Honda Y, Kanekura T, Kiyono T. Molecular cloning and characterization of a novel human papillomavirus, HPV 126, isolated from a flat wart-like lesion with intracytoplasmic inclusion bodies and a peculiar distribution of Ki-67 and p53. Virology, 422:99-104, 2012

49. Egawa N, Nakahara T, Ohno S, Narisawa-Saito M, Yugawa T, Fujita M, Yamato K, Natori Y, Kiyono T. The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome. J Virol, 86:3276-3283, 2012

50. Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M. Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells. J Cell Biol, 197:391-405, 2012

51. Li P, Goto H, Kasahara K, Matsuyama M, Wang Z, Yatabe Y, Kiyono T, Inagaki M. P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. Mol Biol Cell, 23:1582-1592, 2012

52. Narisawa-Saito M, Inagawa Y, Yoshimatsu Y, Haga K, Tanaka K, Egawa N, Ohno S, Ichikawa H, Yugawa T, Fujita M, Kiyono T. A critical role of MYC for transformation of human cells by HPV16 E6E7 and oncogenic HRAS. Carcinogenesis, 33:910-917, 2012

53. Nishimoto N, Watanabe M, Watanabe S, Sugimoto N, Yugawa T, Ikura T, Koiwai O, Kiyono T, Fujita M. Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex. J Cell Sci, 125:3870-3882, 2012

54. Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, Azuma N. Establishment of functioning human corneal endothelial cell line with high growth potential. PLoS One, 7:e29677, 2012

6. Division of Cancer Development System

55. Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S. Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. PLoS One, 7:e43403, 2012

56. Hori M, Onaya H, Takahashi M, Hiraoka N, Mutoh M, Kosuge T, Nakagama H. Invasive ductal carcinoma developing in pancreas with severe fatty infiltration. Pancreas, 41:1137-1139, 2012

57. Hosono K, Yamada E, Endo H, Takahashi H, Inamori M, Hippo Y, Nakagama H, Nakajima A. Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas. World J Gastroenterol, 18:5360-5368, 2012

58. Ishino K, Mutoh M, Totsuka Y, Nakagama H. Metabolic syndrome: A novel high-risk state for colorectal cancer. Cancer Lett, 2012

59. Kato T, Totsuka Y, Ishino K, Matsumoto Y, Tada Y, Nakae D, Goto S, Masuda S, Ogo S, Kawanishi M, Yagi T, Matsuda T, Watanabe M, Wakabayashi K. Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems. Nanotoxicology, 7:452-456, 2012

60. Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T. Origins of albino and hooded rats - implications from molecular genetic analysis across modern laboratory rat strains. PLoS One, 7:e43059, 2012

61. Lin CJ, Nasr Z, Premsrirut PK, Porco Jr. JA, Hippo Y, Lowe SW, Pelletier J. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep, 1:325-333, 2012

62. Matsubara S, Takasu S, Tsukamoto T, Mutoh M, Masuda S, Sugimura T, Wakabayashi K, Totsuka Y. Induction of glandular stomach cancers in Helicobacter pylori-infected Mongolian gerbils by 1-nitrosoindole-3-acetonitrile. Int J Cancer, 130:259-266, 2012

63. Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y. Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene, 2012

64. Uchiyama T, Takahashi H, Endo H, Kato S, Sakai E, Hosono K, Yoneda M, Inamori M, Hippo Y, Nakagama H, Nakajima A. Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence. Dig Endosc, 24:353-357, 2012

7. Division of Metastasis and Invasion Signaling

8. Division of Molecular and Cellular Medicine

65. Furuichi K, Shintani H, Sakai Y, Ochiya T, Matsushima K, Kaneko S, Wada T. Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney. Clin Exp Nephrol, 16:679-689, 2012

66. Gailhouste L. Isolation and purification method of mouse fetal hepatoblasts. Methods Mol Biol, 826:33-47, 2012

67. Goda T, Masuno K, Nishida J, Kosaka N, Ochiya T, Matsumoto A, Miyahara Y. A label-free electrical detection of exosomal microRNAs using microelectrode array. Chem Commun, 48:11942-11944, 2012

68. Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Ochiya T. Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci Rep, 2:314, 2012

69. Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T. Efficacy of a novel class of RNA interference therapeutic agents. PLoS One, 7:e42655, 2012

70. Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A. Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A, 109:4263-4268, 2012

71. Ishikawa T, Banas A, Teratani T, Iwaguro H, Ochiya T. Regenerative cells for transplantation in hepatic failure. Cell Transplant, 21:387-399, 2012

72. Ishikawa T, Hagiwara K, Ochiya T. Generaton and Hepatic Differentiation of Human iPS Cells. Methods Mol Biol, 826:103-114, 2012

73. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci, 95:4831-4841, 2012

74. Katsuda T, Sakai Y, Ochiya T. Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes. J Stem Cells, 7:1-17, 2012

75. Katsuda T, Sakai Y, Ochiya T. Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes. J Stem Cells, 7:1-17, 2012

76. Kawamata M, Ochiya T. Two distinct knockout approaches highlight a critical role for p53 in rat development. Sci Rep, 2:945, 2012

77. Kobayashi S, Yamada-Okabe H, Suzuki M, Natori O, Kato A, Matsubara K, Jau Chen Y, Yamazaki M, Funahashi S, Yoshida K, Hashimoto E, Watanabe Y, Mutoh H, Ashihara M, Kato C, Watanabe T, Yoshikubo T, Tamaoki N, Ochiya T, Kuroda M, Levine AJ, Yamazaki T. LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells, 30:2631-2644, 2012

78. Kosaka N, Iguchi H, Yoshioka Y, Hagiwara K, Takeshita F, Ochiya T. Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem, 287:1397-1405, 2012

79. Kosaka N, Ochiya T. Unraveling the mystery of cancer by secretory microRNA: horizontal microRNA transfer between living cells. Front Genet, 2:97, 2012

80. Morita S, Takahashi RU, Yamashita R, Toyoda A, Horii T, Kimura M, Fujiyama A, Nakai K, Tajima S, Matoba R, Ochiya T, Hatada I. Genome-wide analysis of DNA methylation and Expression of microRNAs in breast cancer cells. Int J Mol Sci, 13:8259-8272, 2012

81. Murakami Y, Toyoda H, Tanahashi T, Tanaka J, Kumada T, Yoshioka Y, Kosaka N, Ochiya T, Taguchi YH. Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease. PLoS One, 7:e48366, 2012

82. Ochiya T. RNA interference. In: Schwab M (ed), Encyclopedia of Cancer, 3rd edition. Germany, Springer, 2012

83. Ochiya T. Secretory microRNAs by Exosomes as a versatile communication tool. Dent Med Res, 32:158-161, 2012

84. Ono M, Fujiwara Y, Ochiya T. Breast cancer stem cell: translating to the clinic. In: Hayat MA (ed), Stem Cells and Cancer Stem Cells, volume 4. Germany, Springer-Verlag, pp 249-257, 2012

85. Takeshita F, Takahashi RU, Onodera J, Ochiya T. In vivo imaging of oligonucleotide delivery. Methods Mol Biol, 872:243-253, 2012

86. Yoshioka Y, Kosaka N, Ochiya T, Kato T. Micromanaging iron homeostasis - Hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins. J Biol Chem, 287:34110-34119, 2012

9. Division of Cancer Biology

87. Miyamoto T, Kitamura N, Ono M, Nakamura Y, Yoshida M, Kamino H, Murai R, Yamada T, Arakawa H. Identification of 14-3-3γ as a Mieap-interacting protein and its role in mitochondrial quality control. Sci Rep, 2:379, 2012

88. Nakamura Y, Kitamura N, Shinogi D, Yoshida M, Goda O, Murai R, Kamino H, Arakawa H. BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. PLoS One, 7:e30767, 2012

10. Division of Cancer Differentiation

89. Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H. Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem, 287:7896-7906, 2012

90. Ishiguro T, Sato A, Ohata H, Sakai H, Nakagama H, Okamoto K. Differential expression of nanog1 and nanogp8 in colon cancer cells. Biochem Biophys Res Commun, 418:199-204, 2012

91. Ohata H, Ishiguro T, Aihara Y, Sato A, Sakai H, Sekine S, Taniguchi H, Akasu T, Fujita S, Nakagama H, Okamoto K. Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells. Cancer Res, 72:5101-5110, 2012

92. Okamoto K, Ishiguro T, Midorikawa Y, Ohata H, Izumiya M, Tsuchiya N, Sato A, Sakai H, Nakagama H. miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. EMBO J, 31:1752-1763, 2012

11. Division of Hematological Malignancy

12. Division of Pharmacogenomics

13. Division of Pharmacoproteomics

93. Fujii K, Suzuki N, Ikeda K, Hamada T, Yamamoto T, Kondo T, Iwatsuki K. Proteomic study identified HSP 70 kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms. J Proteomics, 75:1401-1410, 2012

94. Hosako M, Muto T, Nakamura Y, Tsuta K, Tochigi N, Tsuda H, Asamura H, Tomonaga T, Kawai A, Kondo T. Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker. J Proteomics, 75:833-844, 2012

95. Huang C, Ding G, Gu C, Zhou J, Kuang M, Ji Y, He Y, Kondo T, Fan J. Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1α to promote hepatocellular carcinoma invasiveness. Clin Cancer Res, 18:3042-3053, 2012

96. Ito A, Mimae T, Yamamoto YSZ, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, Kondo T. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. Lab Invest, 92:1374-1385, 2012

97. Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. J Proteomics, 75:1089-1098, 2012

98. Kondo T, Kubota D, Kawai A. Application of proteomics to soft tissue sarcomas. Int J Proteomics, 2012:876401, 2012

99. Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation study on pfetin and ATP-dependent RNA helicase DDX39 as prognostic biomarkers in gastrointestinal stromal tumour. Jpn J Clin Oncol, 42:730-741, 2012

100. Mimae T, Tsuta K, Kondo T, Nitta H, Grogan TM, Okada M, Asamura H, Tsuda H. Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas. Ann Oncol, 23:3129-3137, 2012

101. Mimae T, Tsuta K, Maeshima AM, Okada M, Asamura H, Kondo T, Tsuda H. Cathepsin D as a potential prognostic marker for lung adenocarcinoma. Pathol Res Pract, 208:534-540, 2012

102. Morofuji N, Ojima H, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Asahina D, Ushigome M, Hiraoka N, Nagino M, Kondo T. Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma. J Proteomics, 75:1577-1589, 2012

103. Suehara Y, Kubota D, Kikuta K, Kaneko K, Kawai A, Kondo T. Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma, 2012:425636, 2012

104. Sugihara Y, Taniguchi H, Kushima R, Tsuda H, Kubota D, Ichikawa H, Sakamoto K, Nakamura Y, Tomonaga T, Fujita S, Kondo T. Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer. J Proteomics, 75:5342-5355, 2012

105. Uhlen M, Oksvold P, Algenas C, Hamsten C, Fagerberg L, Klevebring D, Lundberg E, Odeberg J, Ponten F, Kondo T, Sivertsson A. Antibody-based protein profiling of the human chromosome 21. Mol Cell Proteomics, 11:M111.013458, 2012

106. Vegvari A, Kondo T, Marshall JG. Clinical proteomics. Int J Proteomics, 2012:641491, 2012

14. Division of Epigenomics

107. Chiba T, Marusawa H, Ushijima T. Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology, 143:550-563, 2012

108. Frau M, Tomasi ML, Simile MM, Demartis MI, Salis F, Latte G, Calvisi DF, Seddaiu MA, Daino L, Feo CF, Brozzetti S, Solinas G, Yamashita S, Ushijima T, Feo F, Pascale RM. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology, 56:165-175, 2012

109. Katsurano M, Niwa T, Yasui Y, Shigematsu Y, Yamashita S, Takeshima H, Lee MS, Kim YJ, Tanaka T, Ushijima T. Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene, 31:342-351, 2012

110. Kikuyama M, Takeshima H, Kinoshita T, Okochi-Takada E, Wakabayashi M, Akashi-Tanaka S, Ogawa T, Seto Y, Ushijima T. Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation. Cancer Lett, 322:204-212, 2012

111. Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa TO, Oshima M. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene, 31:3949-3960, 2012

112. Matsuda Y, Yamashita S, Lee YC, Niwa T, Yoshida T, Gyobu K, Igaki H, Kushima R, Lee S, Wu MS, Osugi H, Suehiro S, Ushijima T. Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization. Cancer Causes Control, 23:865-873, 2012

113. Nanjo S, Asada K, Yamashita S, Nakajima T, Nakazawa K, Maekita T, Ichinose M, Sugiyama T, Ushijima T. Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection. Gastric Cancer, 15:382-388, 2012

114. Shigematsu Y, Niwa T, Yamashita S, Taniguchi H, Kushima R, Katai H, Ito S, Tsukamoto T, Ichinose M, Ushijima T. Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers. Oncol Lett, 4:268-274, 2012

115. Takeshima H, Ikegami D, Wakabayashi M, Niwa T, Kim YJ, Ushijima T. Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells. Carcinogenesis, 33:2384-2390 , 2012

116. Takeshima H, Ushijima T. Epigenetic epidemiology of infectious diseases. In: Karin B. Michel (ed), Epigenetic Epidemiology . Netherlands, Springer, pp 269-288 , 2012

117. Ushijima T, Hattori N. Molecular Pathways: Involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers. Clin Cancer Res, 18:923-929, 2012

118. Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T, Ichinose M. Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer, 131:2632-2642, 2012

15. Division of Genome Biology

119. Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol, 36:340-351, 2012

120. Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R, Ogiwara H, Oike T, Enari M, Schetter AJ, Okayama H, Haugen A, Skaug V, Chiku S, Yamanaka I, Arai Y, Watanabe S, Sekine I, Ogawa S, Harris CC, Tsuda H, Yoshida T, Yokota J, Shibata T. KIF5B-RET fusions in lung adenocarcinoma. Nat Med, 18:375-377, 2012

121. Kohno T, Shiraishi K. Genetic polymorphisms underlying lung cancer susceptibility and therapeutic response. Genes Environ, 34:94-100, 2012

122. Lan Q, Hsiung CA, Matsuo K, Hong YC, Seow A, Wang Z, Hosgood HD, Chen K, Wang JC, Chatterjee N, Hu W, Wong MP, Zheng W, Caporaso N, Park JY, Chen CJ, Kim YH, Kim YT, Landi MT, Shen H, Lawrence C, Burdett L, Yeager M, Yuenger J, Jacobs KB, Chang IS, Mitsudomi T, Kim HN, Chang GC, Bassig BA, Tucker M, Wei F, Yin Z, Wu C, An SJ, Qian B, Lee VHF, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Kim JH, Gao YT, Tsai YH, Jung YJ, Guo H, Hu Z, Hutchinson A, Wang WC, Klein R, Chung CC, Oh IJ, Chen KY, Berndt SI, He X, Wu W, Chang J, Zhang XC, Huang MS, Zheng H, Wang J, Zhao X, Li Y, Choi JE, Su WC, Park KH, Sung SW, Shu XO, Chen YM, Liu L, Kang CH, Hu L, Chen CH, Pao W, Kim YC, Yang TY, Xu J, Guan P, Tan W, Su J, Wang CL, Li H, Sihoe ADL, Zhao Z, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Kohno T, Kweon SS, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chow WH, Ji BT, Chan JKC, Chu M, Li YJ, Yokota J, Li J, Chen H, Xiang YB, Yu CJ, Kunitoh H, Wu G, Jin L, Lo YL, Shiraishi K, Chen YH, Lin HC, Wu T, Wu YL, Yang PC, Zhou B, Shin MH, Fraumeni JFJ, Lin D, Chanock SJ, Rothman N. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet, 44:1330-1335, 2012

123. Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS One, 7:e52810, 2012

124. Oike T, Ogiwara H, Torikai K, Nakano T, Yokota J, Kohno T. Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys, 84:815-821, 2012

125. Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet, 44:900-903, 2012

126. Yamauchi M, Yamaguchi R, Nakata A, Kohno T, Nagasaki M, Shimamura T, Imoto S, Saito A, Ueno K, Hatanaka Y, Yoshida R, Higuchi T, Nomura M, Beer DG, Yokota J, Miyano S, Gotoh N. Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma. PLoS One, 7:e43923, 2012

16. Division of Cancer Genomics

127. Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet, 44:760-764, 2012

128. Haruta M, Arai Y, Watanabe N, Fujiwara Y, Honda S, Ohshima J, Kasai F, Nakadate H, Horie H, Okita H, Hata J, Fukuzawa M, Kaneko Y. Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children. Cancer Sci, 103:1129-1135, 2012

129. Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell, 22:66-79, 2012

130. Munakata W, Nomoto J, Takahashi N, Taniguchi H, Maeshima AM, Asamura H, Tanosaki R, Heike Y, Fukuda T, Tobinai K, Kobayashi Y. Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation. Am J Surg Pathol, 36:1376-1384, 2012

131. Nakagawa H, Shibata T. Comprehensive genome sequencing of the liver cancer genome. Cancer Lett, 2012

132. Nomoto J, Hiramoto N, Kato M, Sanada M, Maeshima AM, Taniguchi H, Hosoda F, Asakura Y, Munakata W, Sekiguchi N, Maruyama D, Watanabe T, Nakagama H, Takeuchi K, Tobinai K, Ogawa S, Kobayashi Y. Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma. BMC Cancer, 12:457, 2012

133. Ohnishi Y, Totoki Y, Toyoda A, Watanabe T, Yamamoto Y, Tokunaga K, Sakaki Y, Sasaki H, Hohjoh H. Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development. Mol Biol Rep, 39:903-909, 2012

134. Ohshima J, Haruta M, Fujiwara Y, Watanabe N, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y. Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor. Pediatr Blood Cancer, 59:499-505, 2012

135. Ono M, Tsuda H, Shimizu C, Yamamoto S, Shibata T, Yamamoto H, Hirata T, Yonemori K, Ando M, Tamura K, Katsumata N, Kinoshita T, Takiguchi Y, Tanzawa H, Fujiwara Y. Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer. Breast Cancer Res Treat, 132:793-805, 2012

136. Shibata T. Cancer genomics and pathology - all together now. Pathol Int, 62:647-659, 2012

137. Yoshida A, Ushiku T, Motoi T, Beppu Y, Fukayama M, Tsuda H, Shibata T. MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma - correlation with a dedifferentiated subtype. Am J Surg Pathol, 36:423-431, 2012

17. Division of Cancer Pathophysiology

138. Hashimoto H, Uezono Y, Ueta Y. Pathophysiological function of oxytocin secreted by neuropeptides - A mini review. Pathophysiology, 19:283-298, 2012

139. Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Okura D, Sata T. Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes. J Pharmacol Sci, 120:54-58, 2012

140. Iwase S, Yamaguchi T, Miyaji T, Terawaki K, Inui A, Uezono Y. The clinical use of Kampo medicines (traditional Japanese herbal treatments) for controlling cancer patients' symptoms in Japan: a national cross-sectional survey. BMC Complement Altern Med, 12:222, 2012

141. Nakamura Y, Une Y, Miyano K, Abe H, Hisaoka K, Morioka N, Nakata Y. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons. J Neurochem, 120:1036-1047, 2012

142. Onizuka S, Shiraishi S, Tamura R, Yonaha T, Oda N, Kawasaki Y, Syed NI, Shirasaka T, Tsuneyoshi I. Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis. J Anesth, 26:45-53, 2012

143. Onizuka S, Tamura R, Yonaha T, Oda N, Kawasaki Y, Shirasaka T, Shiraishi S, Tsuneyoshi I. Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron. J Anesth, 26:54-61, 2012

144. Sudo Y, Hojo M, Ando Y, Takada M, Murata H, Kurata S, Nishida N, Uezono Y. GABA_B receptors do not internalize after baclofen treatment, possibly due to a lack of β-arrestin association: study with a real-time visualizing assay. Synapse, 66:759-769, 2012

145. Suzuki M, Narita M, Ashikawa M, Furuta S, Matoba M, Sasaki H, Yanagihara K, Terawaki K, Suzuki T, Uezono Y. Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia. Synapse, 66:747-751, 2012

146. Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y. Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice. Anesthesiology, 117:847-856, 2012

147. Uezono Y, Miyano K, Sudo Y, Suzuki M, Shiraishi S, Terawaki K. A review of traditional Japanese medicines and their potential mechanism of action. Curr Pharm Des, 18:4839-4853, 2012

148. Yamamoto M, Takeya M, Ikeshima-Kataoka H, Yasui M, Kawasaki Y, Shiraishi M, Majima E, Shiraishi S, Uezono Y, Sasaki M, Eto K. Increased expression of aquaporin-4 with methylmercury exposure in the brain of the common marmoset. J Toxicol Sci, 37:749-763, 2012

18. Division of Cancer Stem Cell

149. Hirai Y, Masutomi K, Ishikawa F. Kinetics of DNA replication and telomerase reaction at a single-seeded telomere in human cells. Genes Cells, 17:186-204, 2012

150. Nakajima TE, Yoshida H, Okamoto N, Nagashima K, Taniguchi H, Yamada Y, Shimoda T, Masutomi K. Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma. Cancer Sci, 103:233-238, 2012

19. Division of Gene and Immune Medicine

151. Narumi K, Udagawa T, Kondoh A, Kobayashi A, Hara H, Ikarashi Y, Ohnami S, Takeshita F, Ochiya T, Okada T, Yamagishi M, Yoshida T, Aoki K. In vivo delivery of interferon-α gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts. Gene Ther, 19:34-48, 2012

152. Nishimoto T, Yamamoto Y, Yoshida K, Goto N, Ohnami S, Aoki K. Development of peritoneal tumor-targeting vector by in vivo screening with a random peptide-displaying adenovirus library. PLoS One, 7:e45550, 2012

153. Udagawa T, Narumi K, Goto N, Aida K, Suzuki K, Ochiya T, Makimoto A, Yoshida T, Chikaraishi T, Aoki K. Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of intratumoral type I interferon gene transfer for sarcoma. Hum Gene Ther, 23:173-186, 2012

20. Division of Genome Stability Research

154. Fujimori H, Shikanai M, Teraoka H, Masutani M, Yoshioka K. Induction of cancerous stem cells during embryonic stem cell differentiation. J Biol Chem, 287:36777-36791, 2012

155. Hirai T, Shirai H, Fujimori H, Okayasu R, Sasai K, Masutani M. Radiosensitization effect of poly(ADP-ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation. Cancer Sci, 103:1045-1050, 2012

156. Masutani M. The pioneering spirit of Takashi Sugimura: his studies of the biochemistry of poly(ADP-ribosylation) and of cancer. J Biochem, 151:221-228, 2012

157. Osada T, Masutani M. PolyADP-ribosylation in postfertilization and genome reprogramming - implications for carcinogenesis. In: Gomes AS (ed), Polymerization / Book 1, Rijeka. Croatia, In Tech, pp 321-330, 2012

158. Yoshioka K, Atsumi Y, Fukuda H, Masutani M, Teraoka H. The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability. Int J Mol Sci, 13:6492-6506, 2012

21. Division of Chemotherapy and Clinical Research

22. Central Animal Division

159. Cho YM, Imai T, Takami S, Ogawa K, Nishikawa A. Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model. J Toxicol Sci, 37:1025-1034, 2012

160. Hori M, Onaya H, Takahashi M, Hiraoka N, Mutoh M, Kosuge T, Nakagama H. Invasive ductal carcinoma developing in pancreas with severe fatty infiltration. Pancreas, 41:1137-1139, 2012

161. Ota Y, Imai T, Hasumura M, Cho YM, Takami S, Oyamada T, Hirose M, Nishikawa A, Ogawa K. Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine. Toxicol Sci, 127:339-347, 2012

162. Yamazaki T, Aoki K, Heike Y, Kim SW, Ochiya T, Wakeda T, Hoffman RM, Takaue Y, Nakagama H, Ikarashi Y. Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents. Immunol Lett, 144:33-40, 2012

23. Central Radioisotope Division

24. Core Facility Division

25. Division of Refractory Cancer Research

163. Fu B, Yachida S, Morgan R, Zhong Y, Montgomery EA, Iacobuzio-Donahue CA. Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. Am J Clin Pathol, 138:356-366, 2012

164. Inoue T, Yachida S, Usuki H, Kimura T, Hagiike M, Okano K, Suzuki Y. Pilot feasibility study of neoadjuvant chemoradiotherapy with S-1 in patients with locally advanced gastric cancer featuring adjacent tissue invasion or JGCA bulky N2 lymph node metastases. Ann Surg Oncol, 19:2937-2945, 2012

165. Yachida S. Novel therapeutic approaches in pancreatic cancer based on genomic alterations. Curr Pharm Des, 18:2452-2463, 2012

166. Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, de Wilde RF, Maitra A, Hicks J, Demarzo AM, Shi C, Sharma R, Laheru D, Edil BH, Wolfgang CL, Schulick RD, Hruban RH, Tang LH, Klimstra DS, Iacobuzio-Donahue CA. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol, 36:173-184, 2012

167. Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clin Cancer Res, 18:6339-6347, 2012

26. Division of Cancer Prevention Research

168. Shimura M, Yamamoto M, Fujii G, Takahashi M, Komiya M, Noma N, Tanuma SI, Yanaka A, Mutoh M. Novel compound SK-1009 suppresses interleukin-6 expression through modulation of activation of nuclear factor-kappaB pathway. Biol Pharm Bull, 35:2186-2191, 2012

169. Takasu S, Mutoh M, Takahashi M, Nakagama H. Lipoprotein lipase as a candidate target for cancer prevention/therapy. Biochem Res Int, 2012:398697, 2012

170. Ueno T, Imaida K, Yoshimoto M, Hayakawa T, Takahashi M, Imai T, Yanaka A, Tsuta K, Komiya M, Wakabayashi K, Mutoh M. Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice. Anticancer Res, 32:4773-4780, 2012

171. Ueno T, Teraoka N, Takasu S, Nakano K, Takahashi M, Yamamoto M, Fujii G, Komiya M, Yanaka A, Wakabayashi K, Mutoh M. Suppressive effect of pioglitazone, a PPAR gamma ligand, on azoxymethane-induced colon aberrant crypt foci in KK-A^y mice. Asian Pac J Cancer Prev, 13:4067-4073, 2012

172. Yoshimoto M, Hayakawa T, Mutoh M, Imai T, Tsuda K, Kimura S, Umeda IO, Fujii H, Wakabayashi K. In vivo SPECT imaging with ¹¹¹In-DOTA-c(RGDfK) to detect early pancreatic cancer in a hamster pancreatic carcinogenesis model. J Nucl Med, 53:765-771, 2012

27. Division of Integrative Omics and Bioinformatics

173. Hamada A, Sasaki J, Saeki S, Iwamoto N, Inaba M, Ushijima S, Urata M, Kishi H, Fujii S, Semba H, Kashiwabara K, Tsubata Y, Kai Y, Isobe T, Kohrogi H, Saito H. Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer. Pharmacogenomics, 13:615-624, 2012

174. Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, Yoshimura M, Hamada A, Saito H. Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events. Clin Exp Nephrol, 16:843-851, 2012

175. Kato T, Hamada A, Mori S, Saito H. Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis. Drug Metab Pharmacokinet, 27:192-199, 2012

176. Katoh M. Function and cancer genomics of FAT family genes. Int J Oncol, 41:1913-1918, 2012

177. Katoh M. FGF (Fibroblast growth factor). In: Choi S (ed), Encyclopedia of signaling molecules. USA, Springer, pp 603-608, 2012

178. Matoh M. FZD (Frizzled). In: Choi S (ed), Encyclopedia of signaling molecules. USA, Springer, pp 681-687, 2012

179. Satoh T, Kubo A, Shimma S, Toyoda M. Mass Spectrometry imaging and structural analysis of lipids directly on tissue specimens by using a spiral orbit type tandem time-of-flight mass spectrometer, SpiralTOF-TOF. Mass Spectrometry, 1:A0013, 2012

180. Shimma S, Kubo A, Satoh T, Toyoda M. Detailed structural analysis of lipids directly on tissue specimens using a MALDI-SpiralTOF-Reflectron TOF mass spectrometer. PLoS One, 7:e37107, 2012

181. Tsubata Y, Hamada A, Sutani A, Isobe T. Erlotinib-induced acute interstitial lung disease associated with extreme elevation of the plasma concentration in an elderly non-small-cell lung cancer patient. J Cancer Res Ther, 8:154-156, 2012

28. Division of Brain Tumor Translational Research

182. Ichimura K. Molecular pathogenesis of IDH mutations in gliomas. Brain Tumor Pathol, 29:131-139, 2012

183. Ichimura K, Nishikawa R, Matsutani M. Molecular markers in pediatric neuro-oncology. Neuro Oncol, 14 Suppl 4:iv90-99, 2012

184. Mulholland S, Pearson DM, Hamoudi RA, Malley DS, Smith CM, Weaver JMJ, Jones DTW, Kocialkowski S, Backlund LM, Collins VP, Ichimura K. MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations. Int J Cancer, 131:1104-1113, 2012