トップページ > 2010年の刊行論文
2010年の刊行論文
Cumulated List of Papers Published in 2010
- Carcinogenesis Research Group
- 1. Division of Cancer Development System
- 2. Division of Genome Stability Research
- 3. Division of Cancer Differentiation
- 4. Division of Tobacco Policy and Education
- Pathology Group
- 5. Division of Molecular Pathology
- Genomics and Genetics Group
- 6. Division of Genetics
- 7. Division of Cancer Genomics
- 8. Division of Multistep Carcinogenesis
- 9. Division of Genome Biology
- 10. Division of Pharmacogenomics
- 11. Division of Familial Cancer Research
- Epigenomics and Epigenetics Group
- 12. Division of Epigenomics
- 13. Division of Cancer Stem Cell
- Translational Research Group
- 14. Division of Chemotherapy and Clinical Research
- 15. Division of Pharmacoproteomics
- 16. Division of Gene and Immune Medicine
- 17. Division of Molecular and Cellular Medicine
- Molecular Oncology Group
- 18. Division of Hematological Malignancy
- 19. Division of Metastasis and Invasion Signaling
- 20. Division of Virology
- Innovative Pathophysiology Research Group
- 21. Division of Cancer Biology
- 22. Division of Cancer Pathophysiology
- 23. Division of Integrative Omics and Bioinformatics
- 24. Central Animal Division
- 25. Central Radioisotope Division
- 26. Director's Office
- 27. Deputy Director's Office
- 28. President Emeritus
1. Division of Cancer Development System
1. Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama H, Nakajima A. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila), 3:1077-1083, 2010
2. Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A. Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol Carcinog, 49:662-671, 2010
3. Murakami Y, Imai N, Miura T, Sugimura T, Wakabayashi K, Totsuka Y, Hada N, Yokoyama Y, Suzuki H, Mitsunaga K. Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: an authentic synthesis of 9-(4'-nitrophenyl)-9H-pyrido[3,4-b]indole as its relay compound. Heterocycles, 80:455-462, 2010
4. Takahashi H, Hosono K, Uchiyama T, Sugiyama M, Sakai E, Endo H, Maeda S, Schaefer KL, Nakagama H, Nakajima A. PPARg ligand as a promising candidate for colorectal cancer chemoprevention: a pilot study. PPAR Res, 2010:257835, 2010
5. Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Yokohira M, Zeng Y, Kuno T, Totsuka Y, Takahashi M, Wakabayashi K, Imaida K. Tumorigenesis of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice. Oncol Lett, 1:137-142, 2010
6. Tsuchiya N, Nakagama H. MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis. Mutat Res, 693:94-100, 2010
7. Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer, 2010
2. Division of Genome Stability Research
8. Ichijima Y, Yoshioka K, Yoshioka Y, Shinohe K, Fujimori H, Unno J, Takagi M, Goto H, Inagaki M, Mizutani S, Teraoka H. DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS ONE, 5:e8821, 2010
9. Kothe GO, Kitamura M, Masutani M, Selker EU, Inoue H. PARP is involved in replicative aging in Neurospora crassa. Fungal Genet Biol, 47:297-309, 2010
10. Masutani M, Shirai H, Ogino H, Poetsch A, Sasamoto E, Maeda D, Hashimoto A, Sugimura T. Role of poly-ADP-ribosylation in the maintenance of genomic stability. DNA Repair and Human Cancers: Extended Abstracts for The 40th International Symposium of the Princess Takamatsu Cancer Research Fund, pp 76-79, 2010
11. Ogino H, Nakayama R, Sakamoto H, Yoshida T, Sugimura T, Masutani M. Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. Cancer Genet Cytogenet, 197:8-15, 2010
12. Osada T, Ogino H, Hino T, Ichinose S, Nakamura K, Omori A, Noce T, Masutani M. PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice. PLoS ONE, 5:e12526, 2010
3. Division of Cancer Differentiation
13. Izumiya M, Okamoto K, Tsuchiya N, Nakagama H. Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs. Carcinogenesis, 31:1354-1359, 2010
4. Division of Tobacco Policy and Education
5. Division of Molecular Pathology
14. Akishima-Fukasawa Y, Ino Y, Nakanishi Y, Miura A, Moriya Y, Kondo T, Kanai Y, Hirohashi S. Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma. Am J Clin Pathol, 134:71-79, 2010
15. Arai E, Kanai Y. DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status. Epigenomics, 2:467-481, 2010
16. Ban D, Shimada K, Sekine S, Sakamoto Y, Kosuge T, Kanai Y, Hiraoka N. Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol, 34:1025-1036, 2010
17. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, Tonegawa S, Konishi I. Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. Protein Cell, 1:711-717, 2010
18. Hiraoka N. Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology. Int J Clin Oncol, 15:544-551, 2010
19. Hiraoka N, Ino Y, Sekine S, Tsuda H, Shimada K, Kosuge T, Zavada J, Yoshida M, Yamada K, Koyama T, Kanai Y. Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation. Br J Cancer, 103:1057-1065, 2010
20. Hori S, Nara S, Shimada K, Ojima H, Kanai Y, Hiraoka N. Serous cystic neoplasm in an intrapancreatic accessory spleen. Pathol Int, 60:681-684, 2010
21. Hruban RH, Boffetta P, Hiraoka N, Iacobuzio-Donahue C, Kato Y, Kern SE, Klimstra DS, Kloppel G, Maitra A, Offerhaus GJA, Pitman MB. Ductal adenocarcinoma of the pancreas. WHO Classification of Tumours of the Digestive System, 4th edition, pp 281-291, 2010
22. Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci, 101:36-45, 2010
23. Kanai Y, Arai Ei. DNA methylation status in chronic liver disease and hepatocellular carcinoma. Molecular Genetics of Liver Neoplasia, pp 147-159, 2010
24. Matsumoto T, Ojima H, Akishima-Fukasawa Y, Hiraoka N, Onaya H, Shimada K, Mizuguchi Y, Sakurai S, Ishii T, Kosuge T, Kanai Y. Solitary hepatic lymphangioma: report of a case. Surg Today, 40:883-889, 2010
25. Miyake M, Sugano K, Sugino H, Imai K, Matsumoto E, Maeda K, Fukuzono S, Ichikawa H, Kawashima K, Hirabayashi K, Kodama T, Fujimoto H, Kakizoe T, Kanai Y, Fujimoto K, Hirao Y. Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancer. Cancer Sci, 101:250-258, 2010
26. Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. Cancer Sci, 101:231-240, 2010
27. Ojima H, Yoshikawa D, Ino Y, Shimizu H, Miyamoto M, Kokubu A, Hiraoka N, Morofuji N, Kondo T, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Hirohashi S, Kanai Y, Shibata T. Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment. Cancer Sci, 101:882-888, 2010
28. Okamura J, Sekine S, Nara S, Ojima H, Shimada K, Kanai Y, Hiraoka N. Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells. J Clin Pathol, 63:266-269, 2010
29. Shimada K, Sakamoto Y, Nara S, Esaki M, Kosuge T, Hiraoka N. Analysis of 5-year survivors after a macroscopic curative pancreatectomy for invasive ductal adenocarcinoma. World J Surg, 34:1908-1915, 2010
30. Yamamoto Y, Ojima H, Shimada K, Onaya H, Hiraoka N, Mizuguchi Y, Kosuge T, Kanai Y. Long-term recurrence-free survival in a patient with primary hepatic carcinosarcoma: case report with a literature review. Jpn J Clin Oncol, 40:166-173, 2010
6. Division of Genetics
31. Andoh M, Sato Y, Sakamoto H, Yoshida T, Ohtaki M. Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers. J Hum Genet, 55:436-440, 2010
32. Low SK, Kuchiba A, Zembutsu H, Saito A, Takahashi A, Kubo M, Daigo Y, Kamatani N, Chiku S, Totsuka H, Ohnami S, Hirose H, Shimada K, Okusaka T, Yoshida T, Nakamura Y, Sakamoto H. Genome-wide association study of pancreatic cancer in Japanese population. PLoS One, 5:e11824, 2010
33. Saeki N, Gu J, Yoshida T, Wu X. Prostate stem cell antigen: a Jekyll and Hyde molecule?. Clin Cancer Res, 16:3533-3538, 2010
34. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Khuhaprema T, Yoshida T. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat, 123:885-893, 2010
35. Sato Y, Laird NM, Yoshida T. Biostatistic tools in pharmacogenomics-advances, challenges, potential. Curr Pharm Des, 16:2232-2240, 2010
36. Yoshida T, Ono H, Kuchiba A, Saeki N, Sakamoto H. Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: gastric cancer as an example. Cancer Sci, 101:1582-1589, 2010
7. Division of Cancer Genomics
37. Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y. Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma. Genes Chromosomes Cancer, 49:596-609, 2010
38. Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kinoshita T, Tsuda H. p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast. Mod Pathol, 23:662-672, 2010
39. Hasebe T, Tamura N, Iwasaki M, Okada N, Akashi-Tanaka S, Hojo T, Shimizu C, Adachi M, Fujiwara Y, Shibata T, Sasajima Y, Tsuda H, Kinoshita T. Grading system for lymph vessel tumor emboli: significant outcome predictor for patients with invasive ductal carcinoma of the breast who received neoadjuvant therapy. Mod Pathol, 23:581-592, 2010
40. Hasebe T, Tamura N, Okada N, Hojo T, Akashi-Tanaka S, Shimizu C, Tsuda H, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T. p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy. Hum Pathol, 41:262-270, 2010
41. Ium. International network of cancer genome projects. Nature, 464:993-998, 2010
42. Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T. MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev, 24:887-892, 2010
43. Ohnishi Y, Totoki Y, Toyoda A, Watanabe T, Yamamoto Y, Tokunaga K, Sakaki Y, Sasaki H, Hohjoh H. Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucleic Acids Res, 38:5141-5151, 2010
44. Okada N, Hasebe T, Iwasaki M, Tamura N, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kanai Y, Kinoshita T. Metaplastic carcinoma of the breast. Hum Pathol, 41:960-970, 2010
45. Shibata T, Kokubu A, M, Hosoda F, Gotoh M, Tsuta K, Asamura H, Matsuno Y, Kondo T, Imoto I, Inazawa J, Hirohashi S. DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung. Oncogene, 29:4671-4681, 2010
46. Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S. Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway. Cancer Res, 70:9095-9105, 2010
47. Yoshida A, Ushiku T, Motoi T, Shibata T, Fukayama M, Tsuda H. Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant. Am J Surg Pathol, 34:1361-1366, 2010
8. Division of Multistep Carcinogenesis
48. Iwakawa R, Kohno T, Enari M, Kiyono T, Yokota J. Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma. Cancer Sci, 101:1891-1896, 2010
49. Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol, 30:1620-1633, 2010
50. Langevin SM, Ioannidis JPA, Vineis P, Taioli E, Genetic Susceptibility to Environmental Carcinogens group (GSEC). Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines. Pharmacogenet Genomics, 20:586-597, 2010
51. Roy BC, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, Sanchez-Cespedes M, Akiyama T, Yokota J. Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells. Lung Cancer, 70:136-145, 2010
52. Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One, 5:e15541, 2010
53. Yokota J, Shiraishi K, Kohno T. Genetic basis for susceptibility to lung cancer: recent progress and future directions. Adv Cancer Res, 109:51-72, 2010
9. Division of Genome Biology
54. Kohno T, Kakinuma R, Iwasaki M, Yamaji T, Kunitoh H, Suzuki K, Shimada Y, Shiraishi K, Kasuga Y, Hamada Gi, Furuta K, Tsuta K, Sakamoto H, Kuchiba A, Yamamoto S, Kanai Y, Tsugane S, Yokota J. Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs. Carcinogenesis, 31:1794-1799, 2010
55. Kohno T, Kunitoh H, Shimada Y, Shiraishi K, Ishii Y, Goto K, Ohe Y, Nishiwaki Y, Kuchiba A, Yamamoto S, Hirose H, Oka A, Yanagitani N, Saito R, Inoko H, Yokota J. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis, 31:834-841, 2010
56. Kohno T, Otsuka A, Girard L, Sato M, Iwakawa R, Ogiwara H, Sanchez-Cespedes M, Minna JD, Yokota J. A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer, 49:342-352, 2010
57. Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui A. The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell, 40:976-987, 2010
58. Shiraishi K, Kohno T, Tanai C, Goto Y, Kuchiba A, Yamamoto S, Tsuta K, Nokihara H, Yamamoto N, Sekine I, Ohe Y, Tamura T, Yokota J, Kunitoh H. Association of DNA repair gene polymorphisms with response to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol, 28:4945-4952, 2010
10. Division of Pharmacogenomics
11. Division of Familial Cancer Research
59. Yu D, Nagamura Y, Shimazu S, Naito J, Kaji H, Wada S, Honda M, Xue L, Tsukada T. Caspase 8 and menin expressions are not correlated in human parathyroid tumors. Endocr J, 57:825-832, 2010
12. Division of Epigenomics
60. Hattori N, Ushijima T. Analysis of gene-specific DNA methylation. Handbook of Epigenetics: The New Molecular and Medical Genetics, pp 125-134, 2010
61. Herceg Z, Ushijima T. Introduction: epigenetics and cancer. Adv Genet, 70:1-23, 2010
62. Ikegami D, Narita M, Imai S, Miyashita K, Tamura R, Narita M, Takagi S, Yokomizo A, Takeshima H, Ando T, Igarashi K, Kanno J, Kuzumaki N, Ushijima T, Suzuki T. Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine. Addict Biol, 15:358-361, 2010
63. Kuzumaki N, Ikegami D, Imai S, Narita M, Tamura R, Yajima M, Suzuki A, Miyashita K, Niikura K, Takeshima H, Ando T, Ushijima T, Suzuki T, Narita M. Enhanced IL-1b: production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse, 64:721-728, 2010
64. Kuzumaki N, Ikegami D, Tamura R, Sasaki T, Niikura K, Narita M, Miyashita K, Imai S, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T, Suzuki T, Narita M. Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging. Synapse, 64:611-616, 2010
65. Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, Oda I, Gotoda T, Ushijima T. Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication. J Gastroenterol, 45:37-44, 2010
66. Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M, Ushijima T. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res, 70:1430-1440, 2010
67. Niwa T, Ushijima T. Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. Adv Genet, 71:41-56, 2010
68. Perrin D, Ruskin HJ, Niwa T. Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer. J Theor Biol, 264:570-577, 2010
69. Takeshima H, Ushijima T. Methylation destiny: Moira takes account of histones and RNA polymerase II. Epigenetics, 5:89-95, 2010
70. Tomita H, Hirata A, Yamada Y, Hata K, Oyama T, Mori H, Yamashita S, Ushijima T, Hara A. Suppressive effect of global DNA hypomethylation on gastric carcinogenesis. Carcinogenesis, 31:1627-1633, 2010
71. Ushijima T, Asada K. Aberrant DNA methylation in contrast with mutations. Cancer Sci, 101:300-305, 2010
13. Division of Cancer Stem Cell
14. Division of Chemotherapy and Clinical Research
72. Kobayashi E, Masuda M, Nakayama R, Ichikawa H, Satow R, Shitashige M, Honda K, Yamaguchi U, Shoji A, Tochigi N, Morioka H, Toyama Y, Hirohashi S, Kawai A, Yamada T. Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol Cancer Ther, 9:535-544, 2010
73. Matsubara J, Ono M, Honda K, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K, Sugiyama E, Saito Y, Kaniwa N, Sawada J, Shoji A, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T. Survival prediction for pancreatic cancer patients receiving gemcitabine treatment. Mol Cell Proteomics, 9:695-704, 2010
74. Sakane A, Honda K, Sasaki T. Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2. Mol Cell Biol, 30:1077-1087, 2010
75. Satow R, Shitashige M, Jigami T, Honda K, Ono M, Hirohashi S, Yamada T. Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation. J Biol Chem, 285:26289-26294, 2010
76. Satow R, Shitashige M, Kanai Y, Takeshita F, Ojima H, Jigami T, Honda K, Kosuge T, Ochiya T, Hirohashi S, Yamada T. Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res, 16:2518-2528, 2010
77. Shitashige M, Satow R, Jigami T, Aoki K, Honda K, Shibata T, Ono M, Hirohashi S, Yamada T. Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. Cancer Res, 70:5024-5033, 2010
15. Division of Pharmacoproteomics
78. Kikuta K, Gotoh M, Kanda T, Tochigi N, Shimoda T, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kawai A, Hirohashi S, Kondo T. Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities. Jpn J Clin Oncol, 40:60-72, 2010
79. Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T. Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin Appl, 4:560-567, 2010
16. Division of Gene and Immune Medicine
80. Aoki K, Narumi K. Development of interferon-a gene therapy against pancreatic cancer. Cancer Gene Therapy, pp 175-193, 2010
81. Narumi K, Kondoh A, Udagawa T, Hara H, Goto N, Ikarashi Y, Ohnami S, Okada T, Yamagishi M, Yoshida T, Aoki K. Administration route-dependent induction of antitumor immunity by interferon-alpha gene transfer. Cancer Sci, 101:1686-1694, 2010
82. Watanabe S, Ohnuki K, Hara Y, Ishida Y, Ikarashi Y, Ogawa S, Kishimoto H, Tanabe K, Abe R. Suppression of Con A-induced hepatitis induction in ICOS-deficient mice. Immunol Lett, 128:51-58, 2010
17. Division of Molecular and Cellular Medicine
83. Adachi T, Kawakami E, Ishimaru N, Ochiya T, Hayashi Y, Ohuchi H, Tanihara M, Tanaka E, Noji S. Delivery of small interfering RNA with a synthetic collagen poly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo. Dev Growth Differ, 52:693-699, 2010
84. Chowdhury MM, Katsuda T, Montagne K, Kimura H, Kojima N, Akutsu H, Ochiya T, Fujii T, Sakai Y. Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor. Biomed Microdevices, 12:1097-1105, 2010
85. Gu SH, Xu WD, Xu L, Li XK, Ochiya T, Wang Y, Li JF, Gu YD, Xu JG. Regenerated host axons form synapses with neurons derived from neural stem cells transplanted into peripheral nerves. J Int Med Res, 38:1721-1729, 2010
86. Iguchi H, Kosaka N, Ochiya T. Secretory microRNAs as a versatile communication tool. Commun Integr Biol, 3:478-481, 2010
87. Iguchi H, Kosaka N, Ochiya T. Versatile applications of microRNA in anti-cancer drug discovery: from therapeutics to biomarkers. Curr Drug Discov Technol, 7:95-105, 2010
88. Ishikawa T, Banas A, Hagiwara K, Iwaguro H, Ochiya T. Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Ther, 5:182-189, 2010
89. Jazwa A, Kucharzewska P, Leja J, Zagorska A, Sierpniowska A, Stepniewski J, Kozakowska M, Taha H, Ochiya T, Derlacz R, Vahakangas E, Yla-Herttuala S, Jozkowicz A, Dulak J. Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice. Genet Vaccines Ther, 8:6, 2010
90. Katsuda T, Teratani T, Ochiya T, Sakai Y. Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson's disease model rat. J Biochem, 148:281-288, 2010
91. Kawamata M, Ochiya T. Establishment of embryonic stem cells from rat blastocysts. Methods Mol Biol, 597:169-177, 2010
92. Kawamata M, Ochiya T. Generation of genetically modified rats from embryonic stem cells. PNAS, 107:14223-14228, 2010
93. Kosaka N, Iguchi H, Ochiya T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci, 101:2087-2092, 2010
94. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem, 285:17442-17452, 2010
95. Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence, 1:7, 2010
96. Ochiya T, Yamamoto Y, Banas A. Commitment of stem cells into functional hepatocytes. Differentiation, 79:65-73, 2010
97. Takeshita F, Patrawala L, Osaki M, Takahashi R, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, Ochiya T. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther, 18:181-187, 2010
98. Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, Ochiya T. Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA. Cancer Gene Ther, 17:1-10, 2010
18. Division of Hematological Malignancy
99. Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley Ed, Singh H, Tenen DG, Kitabayashi I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med, 16:580-585, 2010
100. Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell, 17:198-212, 2010
19. Division of Metastasis and Invasion Signaling
101. Futami H, Sakai R. All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK. Cancer Lett, 297:220-225, 2010
102. Miyazawa Y, Uekita T, Hiraoka N, Fujii S, Kosuge T, Kanai Y, Nojima Y, Sakai R. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res, 70:5136-5146, 2010
103. Tanaka M, Kamata R, Yanagihara K, Sakai R. Suppression of gastric cancer dissemination by ephrin-B1-derived peptide. Cancer Sci, 101:87-93, 2010
104. Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, Honda Z, Honda H. p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration. Hepatology, 52:1089-1099, 2010
105. Yamaguchi H, Yoshida S, Muroi E, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ia are required for invadopodia formation in human breast cancer cells. Cancer Sci, 101:1632-1638, 2010
20. Division of Virology
106. Aoyagi T, Takahashi M, Higuchi M, Oie M, Tanaka Y, Kiyono T, Aoyagi Y, Fujii M. The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation. Virus Genes, 40:193-199, 2010
107. Ito S, Ozawa S, Ikoma T, Yajima N, Kiyono T, Hata R. Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo. Biomed Res, 31:199-206, 2010
108. Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M. 14-3-3g mediates cdc25a proteolysis to block premature mitotic entry after dna damage. EMBO J, 29:2802-2812, 2010
109. Mori N, Kyo S, Nakamura M, Hashimoto M, Maida Y, Mizumoto Y, Takakura M, Ohno S, Kiyono T, Inoue M. Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer. Br J Cancer, 103:889-898, 2010
110. Yoshida K, Sugimoro N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci, 123:225-235, 2010
111. Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T. DNp63a repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells. Cancer Res, 70:4034-4044, 2010
21. Division of Cancer Biology
112. Cui H, Kamino H, Nakamura Y, Kitamura N, Miyamoto T, Shinogi D, Goda O, Arakawa H, Futamura M. Regulation of apoptosis by p53-inducible transmembrane protein containing sushi domain. Oncol Rep, 24:1193-1200, 2010
113. Miyamoto Y, Futamura M, Kitamura N, Nakamura Y, Baba H, Arakawa H. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. Int J Oncol, 36:1253-1260, 2010
114. Ohnishi S, Futamura M, Kamino H, Nakamura Y, Kitamura N, Miyamoto Y, Miyamoto T, Shinogi D, Goda O, Arakawa H. Identification of NEEP21, encoding neuron-enriched endosomal protein of 21 kDa, as a transcriptional target of tumor suppressor p53. Int J Oncol, 37:1133-1141, 2010
22. Division of Cancer Pathophysiology
115. Minami K, Sudo Y, Shiraishi S, Seo M, Uezono Y. Analysis of the effects of anesthetics and ethanol on m-opioid receptor. J Pharmacol Sci, 112:424-431, 2010
116. Miyano K, Morioka N, Sugimoto T, Shiraishi S, Uezono Y, Nakata Y. Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3. Neurochem Int, 57:923-934, 2010
117. Sudo Y, Matsuo K, Tetsuo T, Tsutsumi S, Ohkura M, Nakai J, Uezono Y. Derived (mutated)-types of TRPV6 channels elicit greater Ca²+ influx into the cells than ancestral-types of TRPV6: evidence from Xenopus oocytes and mammalian cell expression system. J Pharmacol Sci, 114:281-291, 2010
23. Division of Integrative Omics and Bioinformatics
118. Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A. Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice. Hepatology, 52:1111-1123, 2010
119. Katoh M. Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics. Expert Rev Anticancer Ther, 10:1375-1379, 2010
120. Katoh M, Katoh M. Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFb, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. Int J Oncol, 36:415-420, 2010
121. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y. CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem, 285:15511-15522, 2010
122. Mitsunaga S, Fujii S, Ishii G, Kinoshita T, Hasebe T, Aoyagi K, Sasaki H, Ochiai A. Nerve invasion distance is dependent on laminin g2 in tumors of pancreatic cancer. Int J Cancer, 127:805-819, 2010
123. Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T. Up-regulation of PSF1 promotes the growth of breast cancer cells. Genes Cells, 15:1015-1024, 2010
124. Nakayama R, Mitani S, Nakagawa T, Hasegawa T, Kawai A, Morioka H, Yabe H, Toyama Y, Ogose A, Toguchida J, Nakayama T, Yoshida T, Ichikawa H. Gene expression profiling of synovial sarcoma: distinct signature of poorly differentiated type. Am J Surg Pathol, 34:1599-1607, 2010
125. Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell, 6:279-286, 2010
126. Sano M, Aoyagi K, Takahashi H, Kawamura T, Mabuchi T, Igaki H, Tachimori Y, Kato H, Ochiai A, Honda H, Nimura Y, Nagino M, Yoshida T, Sasaki H. Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis. Int J Oncol, 36:321-330, 2010
127. Sentani K, Oue N, Sakamoto N, Anami K, Naito Y, Aoyagi K, Sasaki H, Yasui W. Up-regulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression. Pathobiology, 77:241-248, 2010
128. Shen Y, Chen CS, Ichikawa H, Goldberg GS. SRC induces podoplanin expression to promote cell migration. J Biol Chem, 285:9649-9656, 2010
129. Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H. c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis. Oncogene, 29:5687-5699, 2010
130. Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A. FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells. Exp Hematol, 38:696-706, 2010
131. Takii R, Inouye S, Fujimoto M, Nakamura T, Shinkawa T, Prakasam R, Tan K, Hayashida N, Ichikawa H, Hai T, Nakai A. Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3. J Immunol, 184:1041-1048, 2010
132. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu C, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Calin GA, Croce CM. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol, 11:136-146, 2010
133. Yamamoto T, Morita S, Go R, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R. Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. Int J Radiat Oncol Biol Phys, 77:235-243, 2010
24. Central Animal Division
134. Kitahashi T, Mutoh M, Tsurusaki M, Iinuma G, Suzuki M, Moriyama N, Yoshimoto M, Wakabayashi K, Sugimura T, Imai T. Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT). Cancer Sci, 101:1761-1766, 2010