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ATLAS Project Research Members

National Cancer Center Hospital (Tokyo, Japan)

TAKAHASHI Masamichi (Depertment of Neurosurgery and Neuro-Oncology)


TAKAHASHI Masamichi MD, PhD 

Dr. TAKAHASHI's story

As a neurosurgeon-scientist and a neuro-oncologist, Dr. Masamichi Takahashi's practice is focused on translational research in neuro-oncology, surgical procedure including awake surgery and clinical trials for the patients with brain tumors. Dr. Takahashi was born and raised in Tokyo, receiving his MD degree from Niigata University in 2001 and PhD degree from the University of Tokyo in 2011. His PhD was in Neuroscience, in the laboratory of Drs. Tomoki Todo and Nobuhito Saito, which focused on the third-generation genetically engeneered oncolytic herpes virus (G47Δ). He completed neurosurgery residency training at the University of Tokyo Hospital, and was a postdoctoral fellow in University of California at Los Angeles (UCLA) in the laboratory of Dr. Noriyuki Kasahara, focusing on the translational research of retroviral replicating vector (RRV, TOCA511). After completion of his postdoctoral research, he joined the staff members at National Cancer Center Hospital, Tokyo, JAPAN in 2014, where he is currently in active practice.

Research interests

Dr. Takahashi's research interests are; Primary Brain Tumors (Gliomas, Glioblastomas, others), Machine Learning, Preclinical Study, Clinical Trial, Meningiomas, Pituitary Tumors, Skull Base Tumors, Metastatic Brain Tumors, Other cancers of the central nervous system.

Professional Experiences

  • 2020.5-present   Assistant Chief, Department of Neurosurgery and Neuro-Oncology, NCCH.
  • 2014.7-2020.4   Staff Neurosurgeon, Department of Neurosurgery and Neuro-Oncology, NCCH.
  • 2011.6-2014.6   Postdoctoral Fellow, Department of Medicine, University of California at Los Angeles (UCLA).
  • 2011.4-2011.5   Staff, Department of Neurosurgery, the University of Tokyo Hospital.
  • 2007.4-2011.3   PhD. Student, Department of Neurosurgery, Graduate School of Medicine, the University of Tokyo

Selected publications

  1. Takahashi S, Takahashi M, Tanaka S, Takayanagi S, Takami H, Yamazawa E, et al. A New Era of Neuro-Oncology Research Pioneered by Multi-Omics Analysis and Machine Learning. Biomolecules. 2021;11(4).
  2. Takahashi S, Takahashi M, Kinoshita M, Miyake M, Kawaguchi R, Shinojima N, et al. Fine-Tuning Approach for Segmentation of Gliomas in Brain Magnetic Resonance Images with a Machine Learning Method to Normalize Image Differences among Facilities. Cancers (Basel). 2021;13(6).
  3. Satomi K, Ohno M, Matsushita Y, Takahashi M, Miyakita Y, Narita Y, et al. Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma. Mod Pathol. 2021;34(4):688-700.
  4. Kawauchi D, Takahashi M, Satomi K, Yamamuro S, Kobayashi T, Uchida E, et al. The ALK inhibitors, alectinib and ceritinib, induce ALK-independent and STAT3-dependent glioblastoma cell death. Cancer Sci. 2021.
  5. Tanaka S, Sato I, Takahashi M, Armstrong TS, Cleeland CS, Mendoza TR, et al. Validation study of the Japanese version of MD Anderson Symptom Inventory for Brain Tumor module. Jpn J Clin Oncol. 2020;50(7):787-93.
  6. Miyakita Y, Ohno M, Takahashi M, Kurihara H, Katai H, Narita Y. Usefulness of carbon-11-labeled methionine positron-emission tomography for assessing the treatment response of primary central nervous system lymphoma. Jpn J Clin Oncol. 2020;50(5):512-8.
  7. Miki S, Satomi K, Ohno M, Matsushita Y, Kitahara M, Miyakita Y, et al. Highly sensitive detection of TERT promoter mutations in recurrent glioblastomas using digital PCR. Brain Tumor Pathol. 2020;37(4):154-8.
  8. Deguchi S, Nakasu Y, Sakaida T, Akimoto J, Tanahashi K, Natsume A, et al. Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan. Int J Clin Oncol. 2020;25(11):1995-2005.
  9. Takahashi M, Miki S, Fujimoto K, Fukuoka K, Matsushita Y, Maida Y, et al. Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts. Cancer Sci. 2019;110(7):2247-57.
  10. Ohno M, Matsuzaki J, Kawauchi J, Aoki Y, Miura J, Takizawa S, et al. Assessment of the Diagnostic Utility of Serum MicroRNA Classification in Patients With Diffuse Glioma. JAMA Netw Open. 2019;2(12):e1916953.