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業績

2019年度

  1. Imamura Y, Kiyota N, Ogawa G, Akimoto T, Fujii M, Hanai N, Iwae S, Monden N, Matsuura K, Onozawa Y, Hayashi R, Tahara M; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group. Nutritional support dependence after curative chemoradiotherapy in head and neck cancer: supplementary analysis of a phase II trial (JCOG0706S1). Jpn J Clin Oncol. 49(11):1009-1015, 2019.
  2. Hashimoto J, Kato K, Ito Y, Kojima T, Akimoto T, Daiko H, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Nagashima K, Igaki H. Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma. Int J Clin Oncol. 24(1):60-67, 2019.
  3. Ohnishi K, Nakamura N, Harada H, Tokumaru S, Wada H, Arimura T, Iwata H, Sato Y, Sekino Y, Tamamura H, Mizoe JE, Ogino T, Ishikawa H, Kikuchi Y, Okimoto T, Murayama S, Akimoto T, Sakurai H. Proton Beam Therapy for Histologically or Clinically Diagnosed Stage I Non-small Cell Lung Cancer (NSCLC): The First Nationwide Retrospective Study in Japan. Int J Radiat Oncol Biol Phys. 106(1):82-89, 2020.
  4. Kibe Y, Nakamura N, Kuno H, Hiyama T, Hayashi R, Zenda S, Motegi A, Hojo H, Nakamura M, Ariji T, Oyoshi H, Akimoto T. Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy. Int J Clin Oncol. 24(10):1182-1189, 2019.
  5. Head and Neck Cancer Study Group (HNCSG), Monden N, Asakage T, Kiyota N, Homma A, Matsuura K, Hanai N, Kodaira T, Zenda S, Fujii H, Tahara M, Yokota T, Akimoto T, Iwae S, Onitsuka T, Ogawa T, Okano S, Takahashi S, Shimizu Y, Yonezawa K, Hayashi R.  A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition).  Jpn J Clin Oncol. 49(7):589-595, 2019.
  6. Nishio T, Tachibana H, Kase Y, Hotta K, Nakamura M, Tamura M, Terunuma T, Toshito T, Yamashita H, Ishikura S, Fuji H, Akimoto T, Nishimura Y. Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C). Radiother Oncol. 29; 140:98-104, 2019.
  7. Nakamura N, Hotta K, Zenda S, Baba H, Kito S, Akita T, Motegi A, Hojo H, Nakamura M, Parshuram RV, Okumura M, Akimoto T. Hypofractionated proton beam therapy for centrally located lung cancer. J Med Imaging Radiat Oncol. 63(4):552-556, 2019.
  8. Kawaguchi H, Soejima T, Ishibashi N, Akiba T, Hasegawa M, Isobe K, Ito H, Imai M, Ejima Y, Hata M, Sasai K, Shimoda E, Oguchi M, Akimoto T; Japanese Radiation Oncology Study Group. National survey on total-body irradiation prior to reduced-intensity stem cell transplantation in Japan: The Japanese Radiation Oncology Study Group. J Radiat Res. 60(4):509-516, 2019.
  9. Motegi K, Tachibana H, Motegi A, Hotta K, Baba H, Akimoto T. Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy. J Appl Clin Med Phys. 20(1): 229-236, 2019.
  10. Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T. Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey. J Radiat Res. 2019.
  11. Nakamura M, Kageyama SI, Niho S, Okumura M, Hojo H, Motegi A, Nakamura N, Zenda S, Yoh K, Goto K, Akimoto T. Impact of EGFR Mutation and ALK Translocation on Recurrence Pattern After Definitive Chemoradiotherapy for Inoperable Stage III Non-squamous Non-small-cell Lung Cancer. Clin Lung Cancer. 20(3): e256-e264, 2019.
  12. Niho S, Hosomi Y, Okamoto H, Nihei K, Tanaka H, Hida T, Umemura S, Goto K, Akimoto T, Ohe Y. Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study. Jpn J Clin Oncol. 49(7):614-619, 2019.
  13. Okano S, Enokida T, Onoe T, Ota Y, Motegi A, Zenda S, Akimoto T, Tahara M. Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer.Int J Clin Oncol. 24(7):789-797, 2019.
  14. Hojo H, Dohmae T, Hotta K, Kageyama SI, Baba H, Kohno R, Motegi A, Tsuchihara K, Akimoto T. Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak. Acta Oncol. 11:1-8, 2019.
  15. Sasaki A, Nakamura Y, Mishima S, Kawazoe A, Kuboki Y, Bando H, Kojima T, Doi T, Ohtsu A, Yoshino T, Kuwata T, Akimoto T, Shitara K. Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer. Gastric Cancer. 22(4):793-802, 2019.
  16. Nozaki M, Kagami Y, Shibata T, Nakamura K, Ito Y, Nishimura Y, Kawaguchi Y, Saito Y, Nagata Y, Matsumoto Y, Akimoto T, Hiraoka M; Radiation Therapy Study Group, Japan Clinical Oncology Group. A primary analysis of a multicenter, prospective, single-arm, confirmatory trial of hypofractionated whole breast irradiation after breast-conserving surgery in Japan: JCOG0906. Jpn J Clin Oncol. 49(1):57-62, 2019.

2018年度

  1. Moriya S, Tachibana H, Hotta K, Nakamura N, Sakae T, Akimoto T. Range optimization for target and organs at risk in dynamic adaptive passive scattering proton beam therapy - A proof of concept. Phys Med. 56:66-73, 2018.
  2. Journy N, Indelicato DJ, Withrow DR, Akimoto T, Alapetite C, Araya M, Chang A, Chang JH, Chon B, Confer ME, Demizu Y, Dendale R, Doyen J, Ermoian R, Gurtner K, Hill-Kayser C, Iwata H, Kim JY, Kwok Y, Laack NN, Lee C, Lim DH, Loredo L, Mangona VS, Mansur DB, Murakami M, Murayama S, Ogino T, Ondrová B, Parikh RR, Paulino AC, Perkins S, Ramakrishna NR, Richter R, Rombi B, Shibata S, Shimizu S, Timmermann B, Vern-Gross T, Wang CJ, Weber DC, Wilkinson JB, Witt Nyström P, Yock TI, Kleinerman RA, Berrington de Gonzalez A. Patterns of proton therapy use in pediatric cancer management in 2016: An international survey. Radiother Oncol. 24(1):60-67, 2018.
  3. Matsuzuka T, Kiyota N, Mizusawa J, Akimoto T, Fujii M, Hasegawa Y, Iwae S, Monden N, Matsuura K, Onozawa Y, Hayashi R, Tahara M; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group. Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2). Jpn J Clin Oncol.49(1):37-41, 2019.
  4. Kageyama SI, Nihei K, Karasawa K, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T. Correction: Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients. Oncotarget. 4;9(34):23844, 2018.
  5. Kageyama SI, Nihei K, Karasawa K, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T. Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients. Oncotarget. 10;9(27):19368-19378, 2018.
  6. Nakamura N, Kawamori J, Takahashi O, Shikama N, Sekiguchi K, Takahashi T, Kato S, Ogita M, Motegi A, Akimoto T. Palliative radiotherapy for breast cancer patients with skin invasion: a multi-institutional prospective observational study. Jpn J Clin Oncol. 48(6):555-558, 2018.
  7. Nakamura N, Hojo H, Inoue K, Hotta K, Zenda S, Baba H, Onozawa M, Motegi A, Nakamura M, Kibe Y, Akimoto T. Late radiological changes after passive scattering proton beam therapy for Stage I lung cancer. J Radiat Res. 1;59(4):456-461, 2018.
  8. Hashimoto J, Kato K, Ito Y, Kojima T, Akimoto T, Daiko H, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Nagashima K, Igaki H. Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma. Int J Clin Oncol. 24(1): 60-67, 2018.
  9. Nakamura M, Onozawa M, Motegi A, Hojo H, Zenda S, Nakamura N, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Goto K, Akimoto T. Impact of prophylactic cranial irradiation on pattern of brain metastases as a first recurrence site for limited-disease small-cell lung cancer. J Radiat Res. 2018.
  10. Ishibashi N, Soejima T, Kawaguchi H, Akiba T, Hasegawa M, Isobe K, Ito H, Imai M, Ejima Y, Hata M, Sasai K, Shimoda E, Maebayashi T, Oguchi M, Akimoto T; Japanese Radiation Oncology Study Group. National survey of myeloablative total body irradiation prior to hematopoietic stem cell transplantation in Japan: survey of the Japanese Radiation Oncology Study Group (JROSG). J Radiat Res. 9(4):477-483, 2018.
  11. Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H, Fuji H, Okumura T, Shirato H, Sakurai H. Preliminary results of proton radiotherapy for pediatric rhabdomyosarcoma: a multi-institutional study in Japan. Cancer Med.7(5):1870-1874, 2018.
  12. Iwata H, Ishikawa H, Takagi M, Okimoto T, Murayama S, Akimoto T, Wada H, Arimura T, Sato Y, Araya M, Mizoe JE, Gosho M, Nakamura K, Shirato H, Sakurai H. Long-term outcomes of proton therapy for prostate cancer in Japan: a multi-institutional survey of the Japanese Radiation Oncology Study Group. Cancer Med. 7(3): 677-689, 2018.
  13. Kodaira T, Kagami Y, Shibata T, Shikama N, Nishimura Y, Ishikura S, Nakamura K, Saito Y, Matsumoto Y, Teshima T, Ito Y, Akimoto T, Nakata K, Toshiyasu T, Nakagawa K, Nagata Y, Nishimura T, Uno T, Kataoka M, Yorozu A, Hiraoka M; Radiation Therapy Study Group of the Japan Clinical Oncology Group. Results of a multi-institutional, randomized, non-inferiority, phase 3 trial of accelerated fractionation versus standard fractionation in radiation therapy for T1-2N0M0 glottic cancer: Japan Clinical Oncology Group study (JCOG0701). Ann Oncol. 29(4):992-997, 2018.
  14. Hirano Y, Onozawa M, Hojo H, Motegi A, Zenda S, Hotta K, Moriya S, Tachibana H, Nakamura N, Kojima T, Akimoto T. Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma. Radiat Oncol. 13(1):23, 2018. 
  15. Taira T, Yoh K, Nagase S, Kubota K, Ohmatsu H, Niho S, Onozawa M, Akimoto T, Ohe Y, Goto K. Long-term results of S-1 plus cisplatin with concurrent thoracic radiotherapy for locally advanced non-small-cell lung cancer. Cancer Chemother Pharmacol. 81(3):565-572, 2018.
  16. Hashimoto Y, Motegi A, Akimoto T, Mitsuhashi N, Iizuka J, Tanabe K, Ishii Y, Kono S, Izumi S, Karasawa K. The 5-year outcomes of moderately hypofractionated radiotherapy (66 Gy in 22 fractions, 3 fractions per week) for localized prostate cancer: a retrospective study. Int J Clin Oncol. 23(1):165-172, 2018.

 

2017年度

  1. Nakamura N, Zenda S, Tahara M, Okano S, Hayashi R, Hojo H, Hotta K, Kito S, Motegi A, Arahira S, Tachibana H, Akimoto T. Proton beam therapy for olfactory neuroblastoma. Radiotherapy and Oncology. 2017, 122(3), 368–372.
  2. Demizu Y, Mizumoto M, Onoe T, Nakamura N, Kikuchi Y, Shibata T, Okimoto T, Hideyuki S, Akimoto T, Ono K, Daimon T, Murayama S. Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan. Cancer Sci. 2017, 108(5):972-977.
  3. Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T. Japanese Clinical Practice Guideline for Head and Neck Cancer. Auris Nasus Larynx. 44(4):375-380, 2017.

2016年度

  1. Wu C.T, Motegi A, Motegi K, Hotta K, Kohno R, Tachibana H, Kumagai M, Nakamura N, Hojo H, Niho S, Goto K, Akimoto T. Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced non-small cell lung cancer. JJCO. 2016, 46(11), 1-7.
  2. Motegi A, Arahira S, Zenda S, Hayashi R, Fujii M, Akimoto T. Impact of expression of CD44, a cancer stem cell marker, on the treatment outcomes of intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2016, 94(3): 461-8.
  3. Zenda S, Akimoto T, Mizumoto M, Hayashi R, Arahira S, Okumura T, Sakurai H. Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses. Radiotherapy and Oncology. 2016, 118(2), 267–271.
  4. Mizutani S, Takada Y, Kohno R, Hotta K, Tansho R, Akimoto T. Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams. J Appl Clin Med Phys. 2016, 17(2), 5747.
  5. Hojo H, Domae T, Hotta K, Kohno R, Motegi A, Hirano Y, Onozawa M, Toshima M, Zenda S, Nakamura N, Kibe Y, Arahira S, Tsuchihara K, Akimoto T.  Evaluation of Cellular Response to Proton Beam in Esophageal Cancer Cell Lines.  Int J Radiat Oncol Biol Phys. 2016, 1, 96.
  6. Kohno R, Yamaguchi H, Motegi K, Hotta K, Nishioka S, Akimoto T. In Vivo Dosimetry of an Anthropomorphic Phantom Using the RADPOS for Proton Beam Therapy. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology. 2016, 5(3).
  7. Matsumoto S, Koba Y, Kohno R, Lee C, Bolch W.E, Kai M. Secondary neutron doses to pediatric patients during intracranial proton therapy: Monte Carlo simulation of the neutron energy spectrum and its organ doses. Health Phys. 2016, 110, 380-6.
  8. Kohno R, Yamaguchi H, Motegi K, Hotta K, Miyagishi T, Nishioka S, Dohmae T,  Akimoto T. In vivo dosimetry of an anthropomorphic phantom using the RADPOS for proton beam therapy. IJMPCERO . 2016, 5, 177-183.
  9. Ooishi M, Motegi A, Kawashima M, Arahira S, Zenda S, Nakamura N, Ariji T, Tokumaru S, Sakuraba M, Tahara M, Hayashi R, Akimoto T. Patterns of failure after postoperative intensity-modulated radiotherapy for locally advanced and recurrent head and neck cancer. Jpn J Clin Oncol. 2016, 46(10): 919-927.
  10. Zenke Y, Umemura S, Motegi A, Furukawa K, Kirita K, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Tsuboi M, Akimoto T, Goto K. Acute and Progressive Tracheal Stenosis after Proton Beam Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer. J Thorac Oncol. 2016, 11(7): 1181-3.
  11. Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H, Fuji H, Okumura T, Shirato H, Sakurai H. Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan. Cancer Med. 2016, 5(7): 1519-25.
  12. Zenda S, Ota Y, Tachibana H, Ogawa H, Ishii S, Hashiguchi C, Akimoto T, Ohe Y, Uchitomi Y. A prospective picture collection study for a grading atlas of radiation dermatitis for clinical trials in head-and-neck cancer patients. J Radiat Res. 2016, 57(3): 301-62.
  13. Nakamura N, Takahashi O, Zenda S, Kawamori J, Ogita M, Onozawa M, Arahira S, Toshima M, Motegi A, Hirano Y, Hojo H, Akimoto T. Neuropathic Pain Features in Patients with Bone Metastases. Clin Oncol (R Coll Radiol) 2016, 28: 204-208.
  14. Hirano Y, Nakamura N, Zenda S, Hojo H, Motegi A, Arahira S, Toshima M, Onozawa M, Akimoto T. Incidence and severity of adverse events associated with re-irradiation for spine or pelvic bone metastases. Int J Clin Oncol. 2016, 21(3): 609-14.

2015年度

  1. Hotta K, Kohno R, Nagafuchi K, Yamaguchi H, Tansho R, Takada Y, and Akimoto T; Evaluation of monitor unit calculation based on measurement and calculation with a simplified Monte Carlo method for passive beam delivery system in proton beam therapy; J. Appl. Clin. Med. Phys. 2015, 16, 228-238
  2. Zenda S, Kawashima M, Arahira S, Kohno R, Nishio T, Tahara M, Hayashi R, Akimoto T. Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: importance of long-term follow-up. Int J Clin Oncol. 20(3): 2015, 447-54.
  3. Mizowaki T, Aoki M, Nakamura K, Yorozu A, Kokubo M, Karasawa K, Kozuka T, Nakajima N, Sasai K, Akimoto T. Current status and outcomes of patients developing PSA recurrence after prostatectomy who were treated with salvage radiotherapy: a JROSG surveillance study. J Radiat Res. 2015, 56(4): 750-6.
  4. Tahara M, Kiyota N, Mizusawa J, Nakamura K, Hayashi R, Akimoto T, Hasegawa Y, Iwae S, Monden N, Matsuura K, Fujii H, Onozawa Y, Homma A, Kubota A, Fukuda H, Fujii M. Phase II trial of chemoradiotherapy with S-1 plus cisplatin for unresectable locally advanced head and neck cancer (JCOG0706). Cancer Sci. 2015, 106(6): 726-33.

2014年度

 

    1. Seiji Niho, Atsushi Motegi, and Tetsuo Akimoto. Proton beam therapy with concurrent chemotherapy for non-small cell lung cancer -- our experiences and future direction. Gan To Kagaku Ryoho. 42(2): 144-147, 2015.
    2. Sadamoto Zenda, Mitsuhiko Kawashima, Satoko Arahira, Ryosuke Kohno, Teiji Nishio, Makoto Tahara, Ryuichi Hayashi, Tetsuo Akimoto. Late Toxicity of Proton Beam Therapy for Patients with the nasal cavity, para-nasal sinuses, or involving the skull base Malignancy: Importance of Long-term Follow-up. International Journal of Clinical Oncology. 2014.
    3. Motegi K, Kohno R, Ueda T, Shibuya T, Ariji T, Kawashima M, Akimoto T. Evaluating positional accuracy using megavoltage cone-beam computed tomography for IMRT with head-and-neck cancer. J Radiat Res. 55:568-74, 2014, 2014-10