トップページ > グループ紹介 > 機能診断開発分野(柏) > 業績



  1. Yamaguchi M, Fujii H: Immobilization Technique for High-Resolution MR Imaging of the Testes. Magn Reson Med Sci 17(4): 338-343, 2018.
  2. Iimoto T, Fujii H, Someya S, Matsuzawa H, Yanagawa Y, Kunii K: Cooperation process between a local government and experts in official voluntary decontamination of environmental radioactivity. J Radiat Res 59(Suppl. 2): ii48-ii53, 2018.
  3. Yoshii Y, Yoshimoto M, Matsumoto H, Tashima H, Iwao Y, Takuwa H, Yoshida E, Wakizaka H, Yamaya T, Zhang MR, Sugyo A, Hanadate S, Tsuji AB, Higashi T. Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts. Oncotarget. 9(48):28935-50, 2018.
  4. Yoshimoto M, Honda N, Kurihara H, Hiroi K, Nakamura S, Ito M, Shikano N, Itami J, Fujii H. Non-invasive estimation of BPA-derived boron concentration in tumros by 18F-FBPA PET. Cancer Sci., 109(5):1617-26, 2018
  5. Yoshii Y, Matsumoto H, Yoshimoto M, Zhang MR, Oe Y, Kurihara H, Narita Y, Jin ZH, Tsuji AB, Yoshinaga K, Fujibayashi Y, Higashi T. Multiple Administrations of 64Cu-ATSM as a Novel Therapeutic Option for Glioblastoma: a Translational Study Using Mice with Xenografts. Transl. Oncol., 11(1):24-30, 2018


  1. Yoshii Y, Yoshimoto M, Matsumoto H, Furukawa T, Zhang MR, Inubushi M, Tsuji AB, Fujibayashi Y, Higashi T, Saga T. 64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts. Oncotarget. 8(51):88815-26, 2017
  2. Ogawa-Morita T, Sano Y, Okano T, Hirofumi Fujii, Tahara M, Yamaguchi M, Minami H: Validation of a liquid chromatography-tandem masss pectrometric assay for quantitative analysis of lenvatinib in human plasma. Int J Anal Chem 2017(2341876): 1-6, 2017.
  3. Kano D, Nakagami Y, Kurihara H, Hosokawa S, Zenda S, Kusumoto M, Fujii H, Kaneta T, Saito S, Uesawa Y, Kagaya H: Development of a double-stranded siRNA labelling method by using 99mTc and single photon emission computed tomography imaging. J Drug Target 25(2): 172-178, 2017.
  4. Furuta T, Yamaguchi M, Minami M, Ohtomo K, Fujii H: Persistent T2*-hypointensity of the liver parenchyma after irradiation to the SPIO-accumulated liver: An imaging marker for responses to radiotherapy in hepatic malignancies. J Magn Reson Imaging 45(1): 303-312, 2017.
  5. Kagawa S, Nishii R, Higashi T, Yamauchi H, Ogawa E, Okudaira H, Kobayashi M, Yoshimoto M, Shikano N, Kawai K. Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: comparison with [3H]Methionine uptake. Nucl Med Biol 49 (1):8-15, 2017


  1. Morita TO, Yamaguchi A, Kimura S, Fujii H, Endo K, Izumi K, Saito S, Minami H: Stability of lenalidomide suspension after preparation by a simple suspension method for enteral tube administration. J Oncol Pharm Pract 22(4): 579-83, 2016.
  2. Kamimura M, Saito R, Hyodo H, Tsuji K, Umeda IO, Fujii H, Soga K: Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal in vivo Imaging Based on Rare-earth Doped Ceramic Nanophosphors. J Photopolym Sci Technol 29(4): 525-532, 2016.
  3. Yoshii Y, Furukawa T, Matsumoto H, Yoshimoto M, Kiyono Y, Zhang MR, Fujibayashi Y, Saga T: 64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133(+) cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite. Cancer Lett 376(1): 74-82, 2016.
  4. Kimura S, Kakishima Y, Kuchimaru T, Kizaka-Kondoh S, Yoshimoto M, Fujii H, Umeda IO: Application of HaloTag® Technology to in Vivo Molecular Imaging Using Protein Probes Labeled by Metallic Radionuclides. RADIOISOTOPES 65(6): 247-255, 2016.
  5. Ito K, Hamamichi S, Asano M, Hori Y, Matsui J, Iwata M, Funahashi Y, Umeda IO, Fujii H: Radiolabeled liposome imaging determines an indication for liposomal anticancer agent in ovarian cancer mouse xenograft models. Cancer Sci 107(1): 60-67, 2016.
  6. Kinoshita T, Fujii H, Hayashi Y, Kamiyama I, Ohtsuka T, Asamura H: Prognostic significance of hypoxic PET using 18F-FAZA and 62Cu-ATSM in non-small-cell lung cancer. Lung Cancer 91(1): 56-66, 2016.


  1. Iimoto T, Nunokawa J, Fujii H, Takashima R, Hashimoto M, Fukuhara T, Yajima T, Matsuzawa H, Kurosawa K, Yanagawa Y, Someya S: Collaboration of local government and experts responding to increase in environmental radiation level due to the nuclear disaster: focusing on their activities and latest radiological discussion. Radiat Prot Dosimetry 167(1-3): 358-64, 2015.
  2. Fujii H, Iimoto T, Tsuzuki T, Iiizumi S, Someya S, Hamamichi S, Kessler MM: Collaboration of local governments and experts responding to the increase of the environmental radiation level secondary to the nuclear accident: a unique activity to relieve residents' anxiety. Radiat Prot Dosimetry 167(1-3): 370-5, 2015.
  3. Okamoto M, Naka K, Kitagawa Y, Ishiwata K, Yoshimoto M, Shimizu I, Toyohara J: Synthesis and evaluation of 7alpha-(3-[18F]fluoropropyl) estradiol. Nucl Med Biol 42(7): 590-7, 2015.
  4. Nagai M, Yamaguchi M, Mori K, Furuta T, Ashino H, Kurosawa H, Kasahara H, Minami M, Fujii H: Magnetic resonance-based visualization of thermal ablative margins around hepatic tumors by means of systemic ferucarbotran administration before radiofrequency ablation: animal study to reveal the connection between excess iron deposition and t2*-weighted hypointensity in ablative margins. Invest Radiol 50(6): 376-83, 2015.
  5. Yoshimoto M, Kurihara H, Fujii H: Theragnostic imaging using radiolabeled antibodies and tyrosine kinase inhibitors. Sci World J 2015(842101): 1-6, 2015.


  1. Furuta T, Yamaguchi M, Nakagami R, Akahane M, Minami M, Ohtomo K, Fujii H: Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation. MAGMA 27(6): 501-8, 2014.
  2. Tani H, Kurihara H, Hiroi K, Honda N, Yoshimoto M, Kono Y, Murakami R, Kumita S, Arai Y, Itami J: Correlation of (18)F-BPA and (18)F-FDG uptake in head and neck cancers. Radiother Oncol 113(2): 193-7, 2014.
  3. Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS: Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion. J Nucl Med 55(11): 1899-1904, 2014.
  4. Nakagami R, Yamaguchi M, Ezawa K, Kimura S, Hamamichi S, Sekine N, Furukawa A, Niitsu M, Fujii H: Recovery Correction Technique for NMR Spectroscopy of Perchloric Acid Extracts using DL-valine-2,3-d2: Validation and Application to 5-Fluorouracil-induced brain damage. Magn Reson Med Sci 13(3): 145-153, 2014.
  5. Araki K, Mizokami D, Tomifuji M, Yamashita T, Ohnuki K, Umeda IO, Fujii H, Kosuda S, Shiotani A: Novel Indocyanine Green-Phytate Colloid Technique for Sentinel Node Detection in Head and Neck: Mouse Study. Otolaryngol Head Neck Surg 151(2): 279-285, 2014.
  6. Yoshimoto M, Hirata M, Kanai Y, Naka S, Nishii R, Kagawa S, Kawai K, Ohmomo Y: Monitoring of Gefitinib Sensitivity with Radioiodinated PHY Based on EGFR Expression. Biol Pharm Bull 37(3): 355-60, 2014.
  7. Yoshii Y, Matsumoto H, Yoshimoto M, Furukawa T, Morokoshi Y, Sogawa C, Zhang MR, Wakizaka H, Yoshii H, Fujibayashi Y, Saga T: Controlled Administration of Penicillamine Reduces Radiation Exposure in Critical Organs during (64)Cu-ATSM Internal Radiotherapy: A Novel Strategy for Liver Protection. PLoS One 9(1): e86996, 2014.
  8. Ogawa M, Umeda IO, Kosugi M, Kawai A, Hamaya Y, Takashima M, Yin H, Kudoh T, Seno M, Magata Y: Development of 111In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging. J Nucl Med 55(1): 115-20, 2014.
  9. Takeda A, Sanuki N, Fujii H, Yokosuka N, Nishimura S, Aoki Y, Oku Y, Ozawa Y, Kunieda E: Maximum Standardized Uptake Value on FDG-PET Is a Strong Predictor of Overall and Disease-Free Survival for Non-Small-Cell Lung Cancer Patients after Stereotactic Body Radiotherapy. J Thorac Oncol 9(1): 65-73, 2014.


  1. Hayakawa T, Mutoh M, Imai T, Tsuta K, Yanaka A, Fujii H, Yoshimoto M: SPECT/CT of lung nodules using 111In-DOTA-c(RGDfK) in a mouse lung carcinogenesis model. Ann Nucl Med 27(7): 640-7, 2013.
  2. Yamaguchi M, Mitsuda M, Ezawa K, Nakagami R, Furuta T, Sekine N, Niitsu M, Fujii H: Artifact-reduced simultaneous MRI of multiple rats with liver cancer using PROPELLER. J Magn Reson Imaging 38(1): 225-30, 2013.
  3. Yoshimoto M, Kurihara H, Honda N, Kawai K, Ohe K, Fujii H, Itami J, Arai Y: Predominant contribution of L-type amino acid transporter to 4-borono-2-(18)F-fluoro-phenylalanine uptake in human glioblastoma cells. Nucl Med Biol 40(5): 625-9, 2013.
  4. Hirata M, Kanai Y, Naka S, Yoshimoto M, Kagawa S, Matsumuro K, Katsuma H, Yamaguchi H, Magata Y, Ohmomo Y: A useful EGFR-TK ligand for tumor diagnosis with SPECT: development of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline. Ann Nucl Med 27(5): 431-43, 2013.
  5. Mitsuda M, Yamaguchi M, Nakagami R, Furuta T, Sekine N, Niitsu M, Moriyama N, Fujii H: Intensity Correction Method Customized for Multi-animal Abdominal MR Imaging with 3T Clinical Scanner and Multi-Array Coil. Magn Reson Med Sci 12(2): 95-103, 2013.
  6. Furuta T, Yamaguchi M, Nakagami R, Akahane M, Minami M, Ohtomo K, Moriyama N, Fujii H: Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images: an experimental study in rat livers with gadolinium chloride-induced Kupffer cell damage. MAGMA 26(3): 313-24, 2013.
  7. Suzuki C, Blomqvist L, Hatschek T, Carlsson L, Einbeigi Z, Linderholm B, Lindh B, Loman N, Malmberg M, Rotstein S, Soderberg M, Sundqvist M, Walz TM, Astrom G, Fujii H, Jacobsson H, Glimelius B: Impact of the first tumor response at eight weeks on overall survival in metastatic breast cancer patients treated with first-line combination chemotherapy. Med Oncol 30(1): 415, 2013.
  8. Takeda A, Kunieda E, Fujii H, Yokosuka N, Aoki Y, Oooka Y, Oku Y, Ohashi T, Sanuki N, Mizuno T, Ozawa Y: Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer. Lung Cancer 79(3): 248-53, 2013.
  9. Fujii H, Umeda IO, Iimoto T, Oda S, Someya S, Iiizumi S: Increased Radiation Dose Issues in Tokatsu Area in Chiba Prefecture, Japan – How the Situation and Measures were Explained to the Local Residents –. Radiat Emerg Med 2(1): 76-81, 2013.


  1. Ueno T, Imaida K, Yoshimoto M, Hayakawa T, Takahashi M, Imai T, Yanaka A, Tsuta K, Komiya M, Wakabayashi K, Mutoh M: Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice. Anticancer Res 32(11): 4773-80, 2012.
  2. Iimoto T, Fujii H, Oda S, Nakamura T, Hayashi R, Kuroda R, Furusawa M, Umekage T, Ohkubo Y: Measures against increased environmental radiation dose by the TEPCO Fukushima Dai-ichi NPP accident in some local governments in the Tokyo metropolitan area: focusing on examples of both Kashiwa and Nagareyama cities in Chiba prefecture. Radiat Prot Dosimetry 152(1-3): 210-4, 2012.
  3. Kaburagi T, Takeuchi H, Fujii H, Saikawa Y, Murakami K, Fukada J, Shigematsu N, Ozawa S, Ando N, Kitagawa Y: Initial experience of individualized chemoradiotherapy for superficial esophageal cancers based on the sentinel lymph node concept. Esophagus 9(3): 147-152, 2012.
  4. Kutsuna N, Higaki T, Matsunaga S, Otsuki T, Yamaguchi M, Fujii H, Hasezawa S: Active learning framework with iterative clustering for bioimage classification. Nat Commun 3(1032): 1-10, 2012.
  5. Inoue K, Kurosawa H, Tanaka T, Fukushi M, Moriyama N, Fujii H: Optimization of injection dose based on noise-equivalent count rate with use of an anthropomorphic pelvis phantom in three-dimensional 18F-FDG PET/CT. Radiol Phys Technol 5(2): 115-22, 2012.
  6. Masunaga S, Kimura S, Harada T, Okuda K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Nagasawa H, Ono K: Evaluating the usefulness of a novel 10B-carrier conjugated with cyclic RGD peptide in boron neutron capture therapy. World J Oncol 3(3): 103-112, 2012.
  7. Hirata M, Kanai Y, Naka S, Matsumuro K, Kagawa S, Yoshimoto M, Ohmomo Y: Synthesis and evaluation of radioiodinated phenoxyquinazoline and benzylaminoquinazoline derivatives as new EGF receptor tyrosine kinase imaging ligands for tumor diagnosis using SPECT. Ann Nucl Med 26(5): 381-389, 2012.
  8. Ejiri K, Minami K, Toyama H, Kudo G, Hattori H, Kobayashi N, Kato M, Ishiguro M, Fujii H, Kuroda M, Utsumi T, Iwase K, Katada K: Sentinel node navigation surgery with 99mTc-tin colloid in breast cancer: radiation safety considerations. Open Med Imaging J 6: 89-96, 2012.
  9. Fujii H, Idoine JD, Gioux S, Accorsi R, Slochower DR, Lanza RC, Frangioni JV: Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping. Mol Imaging Biol 14(2): 173-82, 2012.
  10. Yoshimoto M, Hayakawa T, Mutoh M, Imai T, Tsuda K, Kimura S, Umeda IO, Fujii H, Wakabayashi K: In Vivo SPECT Imaging with 111In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model. J Nucl Med 53(5): 765-771, 2012.
  11. Kitamura N, Kosuda S, Araki K, Tomifuji M, Mizokami D, Shiotani A, Shinmoto H, Fujii H, Ichihara K: Comparison of animal studies between interstitial magnetic resonance lymphography and radiocolloid SPECT/CT lymphoscintigraphy in the head and neck region. Ann Nucl Med 26(3): 281-5, 2012.
  12. Suzuki D, Yamaguchi M, Furuta T, Okuyama Y, Yoshikawa K, Fujii H: Central High Signal in Inflammatory Swollen Lymph Nodes on SPIO-enhanced Interstitial MR Lymphograms: A Mimic of Lymph Node Metastasis. Magn Reson Med Sci 11(1): 61-3, 2012.
  13. Umeda IO, Tani K, Tsuda K, Kobayashi M, Ogata M, Kimura S, Yoshimoto M, Kojima S, Moribe K, Yamamoto K, Moriyama N, Fujii H: High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging. Ann Nucl Med 26(1): 67-76, 2012.