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Feeding a High-Fat Diet for a Limited Duration Increases Cancer Incidence in a Breast Cancer Model.
Imai T, Naruse M, Machida Y, Fujii G, Mutoh M, Ochiai M, Takahashi M, Nakagama H.
Nutr. Cancer, 75, 713-725, 2023, PMID: 36263881

Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids.
Kodera T, Takeuchi RF, Takahashi S, Suzuki K, Kassai H, Aiba A, Shiozawa S, Okano H, Osakada F.
Biochem. Biophys. Res. Commun., 657, 119-127, 2023, PMID: 37002985

Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.
Toyoda Y, Miyata H, Uchida N, Morimoto K, Shigesawa R, Kassai H, Nakao K, Tomioka NH, Matsuo H, Ichida K, Hosoyamada M, Aiba A, Suzuki H, Takada T.
Pflugers Arch., 475, 489-504, 2023, PMID: 36749388

Different types of reactions to E7386 among colorectal cancer patient-derived organoids and corresponding CAFs.
Imai T, Naruse M, Ochiai M, Matsumoto K, Ikeda S, Kani M, Kato Y, Hirayama A, Soga T, Hori Y, Yokoi A, Ochiai A.
Oncol. Lett., 24, 221, 2022, PMID: 35707761

The potential of organoids in toxicologic pathology: Histopathological and immunohistochemical evaluation of a mouse normal tissue-derived organoid-based carcinogenesis model.
Ishigamori R, Naruse M, Hirata A, Maru Y, Hippo Y, Imai T.
J. Toxicol. Pathol., 35, 211-223, 2022, PMID: 35832903

Establishment of Novel Genotoxicity Assay System Using Murine Normal Epithelial Tissue-Derived Organoids.
Komiya M, Ishigamori R, Naruse M, Ochiai M, Miyoshi N, Imai T, Totsuka Y.
Front. Genet., 12, 768781, 2021, PMID: 34868254

The unique genetic and histological characteristics of DMBA-induced mammary tumors in an organoid-based carcinogenesis model.
Naruse M, Ishigamori R, Imai T.
Front. Genet., 12, 765131, 2021, PMID: 34912374

Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c Trp53 knockout mice.
Machida Y, Imai T.
Oncol. Lett., 22, 738, 2021, PMID: 34466150

Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs.
Naruse M, Ochiai M, Sekine S, Taniguchi H, Yoshida T, Ichikawa H, Sakamoto H, Kubo T, Matsumoto K, Ochiai A, Imai T.
Sci. Rep., 11, 2077, 2021, PMID: 33483567

14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice.
Yokoi N, Fukata Y, Okatsu K, Yamagata A, Liu Y, Sanbo M, Miyazaki Y, Goto T, Abe M, Kassai H, Sakimura K, Meijer D, Hirabayashi M, Fukai S, Fukata M.
Cell Rep., 37, 110107, 2021, PMID: 34910912

Telencephalon-specific Alkbh1 conditional knockout mice display hippocampal atrophy and impaired learning.
Kawarada L, Fukaya M, Saito R, Kassai H, Sakagami H, Aiba A.
FEBS Lett., 595, 1671-1680, 2021, PMID: 33930188

An organoid-based carcinogenesis model induced by in vitro chemical treatment.
Naruse M, Masui R, Ochiai M, Maru Y, Hippo Y, Imai T.
Carcinogenesis, 41, 10.1444-1453, 2020, PMID: 32047892

A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy.
Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka H.
Pancreatol., 20: 551-557, 2020, PMID: 31917123

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.
Toyoda Y, Takada T, Miyata H, Matsuo H, Kassai H, Nakao K, Nakatochi M, Kawamura Y, Shimizu S, Shinomiya N, Ichida K, Hosoyamada M, Aiba A, Suzuki H.
Proc. Natl. Acad. Sci. USA., 117, 18175-18177, 2020, PMID: 32690690

Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate.
Kurano M, Tsukamoto K, Shimizu T, Kassai H, Nakao K, Aiba A, Hara M, Yatomi Y.
Diabetes, 69, 867-881, 2020, PMID: 31915150

Increased susceptibility to mammary carcinogenesis and an opposite trend in endometrium in Trp53 heterozygous knockout female mice by back-crossing the BALB/c strain onto the background C3H strain.
Machida Y, Sudo Y, Uchiya N, Imai T.
J. Toxicol. Pathol., 32, 197-203, 2019, PMID: 31404346

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells.
Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, Hashimoto K, Sakagami H, Kano M, Aiba A.
Sci. Rep., 9, 2799, 2019, PMID: 30808980

Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans.
Takahashi M, Hori M, Ishigamori R, Mutoh M, Imai T, Nakagama H.
Cancer Sci., 109, 3013-3023, 2018, PMID: 30099827

Activated ductal proliferation induced by N-nitrosobis(2-oxopropyl)amine in fat-infiltrated pancreas of KK-Ay mice.
Hori M, Mutoh M, Ishigamori R, Imai T, Takahashi M.
In Vivo, 32, 499-505, 2018, PMID: 29695552

New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines.
Naito R, Kassai H, Sakai Y, Schönherr S, Fukaya M, Schwarzer C, Sakagami H, Nakao K, Aiba A, Ferraguti F.
Front. Mol. Neurosci., 11, 439, 2018, PMID: 30559646

Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.
Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y.
Thromb. Haemost., 118, 1021-1035, 2018, PMID: 29669385

Oocyte-activating capacity of fresh and frozen-thawed spermatids in the common marmoset (Callithrix jacchus).
Ogonuki N, Inoue H, Matoba S, Kurotaki YK, Kassai H, Abe Y, Sasaki E, Aiba A, Ogura A.
Mol. Reprod. Dev., 85, 376-386, 2018, PMID: 29457675

Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).
Ueda J, Murata Y, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K.
Neurosci. Res., 120, 60-65, 2017, PMID: 28215819

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.
Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang PJ, Noda S, Nakao K, Kassai H, Sato T, Aiba A, Hatakeyama M.
Nat. Commun., 7, 12887, 2016, PMID: 27650679

Rho GTPase protein Cdc42 is critical for postnatal cartilage development.
Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
Biochem. Biophys. Res. Commun., 470, 813-817, 2016, PMID: 26820532

Cdc42 is crucial for facial and palatal formation during craniofacial development.
Oshima-Nakayama M, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, Kassai H, Sato Y, Yamamoto M, Shirota T, Aiba A, Maki K, Kamijo R.
Bone Rep., 5, 1-6, 2016, PMID: 28326341

Generation of cloned mice from adult neurons by direct nuclear transfer.
Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A.
Biol. Reprod., 92, 81., 2015, PMID: 25653280

Cdc42 is critical for cartilage development during endochondral ossification.
Suzuki W, Yamada A, Aizawa R, Suzuki D, Kassai H, Harada T, Nakayama M, Nagahama R, Maki K, Takeda S, Yamamoto M, Aiba A, Baba K, Kamijo R.
Endocrinology, 156, 314-22, 2015, PMID: 25343271

The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain.
Hamada S, Ogawa I, Yamasaki M, Kiyama Y, Kassai H, Watabe AM, Nakao K, Aiba A, Watanabe M, Manabe T.
Eur. J. Neurosci., 40, 3136-46, 2014, PMID: 25131300

A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.
Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, Minamino T.
PLoS One, 9, e102186, 2014, PMID: 25057989

Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.
Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A.
Cell Rep., 7, 1626-1639, 2014, PMID: 24857653

Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells.
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N.
J. Cell Sci., 127, 2040-2052, 2014, PMID: 24610943

The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.
Ohtani Y, Miyata M, Hashimoto K, Tabata T, Kishimoto Y, Fukaya M, Kase D, Kassai H, Nakao K, Hirata T, Watanabe M, Kano M, Aiba A.
J. Neurosci., 34, 2702-2712, 2014, PMID: 24523559

High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene –induced mammary carcinogenesis.
Imai, T., Cho, Y.M., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K.
Oncol. Rep., 29, 1914-1922, 2013, PMID:23467805

Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells.
Kato HK, Kassai H, Watabe AM, Aiba A, Manabe T.
J. Physiol., 590, 3019-34, 2012, PMID: 22586220

Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R.
Mech. Dev., 129, 38-50, 2012, PMID: 22387309

Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.
Kassai H, Terashima T, Fukaya M, Nakao K, Sakahara M, Watanabe M, Aiba A.
Eur. J. Neurosci., 28, 257-67, 2008, PMID: 18702697

G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.
Tabata T, Kawakami D, Hashimoto K, Kassai H, Yoshida T, Hashimotodani Y, Fredholm BB, Sekino Y, Aiba A, Kano M.
J. Physiol., 581, 693-708, 2007, PMID: 17379632

Farnesylation of retinal transducin underlies its translocation during light adaptation.
Kassai H, Aiba A, Nakao K, Nakamura K, Katsuki M, Xiong WH, Yau KW, Imai H, Shichida Y, Satomi Y, Takao T, Okano T, Fukada Y.
Neuron, 47, 529-539, 2005, PMID: 16102536

Top-down analysis of protein isoprenylation by electrospray ionization hybrid quadrupole time-of-flight tandem mass spectrometry; the mouse Tgamma protein.
Kassai H, Satomi Y, Fukada Y, Takao T.
Rapid Commun. Mass Spectrom., 19, 269-274, 2005, PMID: 15609361