原著論文

2025年

1. Ogawa A, Izumikawa K, Tate S, Isoyama S, Mori M, Fujiwara K, Watanabe S, Ohga T, Jo U, Taniyama D, Kitajima S, Tanaka S, Onji H, Kageyama SI, Yamamoto G, Saito H, Morita TY, Okada M, Natsumeda M, Nagahama M, Kobayashi J, Ohashi A, Sasanuma H, Higashiyama S, Dan S, Pommier Y, Murai J. SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis. Mol Cell 2025 March 6; Pages 894-912.e10. doi: 10.1016/j.molcel.2025.01.008.
2. Yamamoto G*, Tanaka K*, Ryo Kamata, Saito H, Morita TY, Nakao T, Liu J, Mori S, Yagishita S, Hamada A, Shinno Y, Yoshida T, Horinouchi H, Ohe Y, Watanabe S, Yatabe Y, Kitai H, Konno S, Kobayashi SS, Ohashi A. *Contributed equally. WEE1 Confers Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer. Cancer Letters 2025 February 28; 217414. doi: 10.1016/j.canlet.2024.217414
3. Minamide T, Minakata N, Yamashita R, Sakashita S, Yoda Y, Ohashi A, Aoshima M, Kobayashi S, Yano T. Oxygen saturation imaging elucidates tumor heterogeneity in gastric cancer. DEN Open 2025 Feb 21;5(1):e70077. doi: 10.1002/deo2.70077.

2024年

1. Yamashima T, Mochly-Rosen D, Wakatsuki S, Mizukoshi E, Seike T, Larus IM, Chen CH, Takemura M, Saito H, Ohashi A. Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions. Front Mol Biosci. 2024 May 27:11:1378656. doi: 10.3389/fmolb.2024.1378656.

2023年

1. Morita TY*, Yu J*, Kashima Y*, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. *Contributed equally. CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade. Nat Commun. 2023 Nov 18;14(1):7490. doi: 10.1038/s41467-023-43274-3.
2. Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, Sakuma K, Kurauchi J, Akter E, Konno M, Ishibashi K, Kamata R, Ohashi A, Koseki J, Takahashi H, Yokoyama H, Shiraki Y, Enomoto A, Abe S, Hayakawa Y, Ushiku T, Mutoh M, Fujita Y, Kon S. Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway. Nat Commun. 2023 Nov 3;14(1):7048. doi: 10.1038/s41467-023-42774-6.

2022年

1. Yamashita H, Nakajo K, Takashima K, Murano T, Kadota T, Sinmura K, Yoda Y, Ikematsu H, Fujii S, Yano T. Recurrent metastasis risk factors in esophageal cancer after salvage endoscopic resection for local failure following chemoradiotherapy. Dig Endosc. 2022 Nov;34(7):1356-1369. doi: 10.1111/den.14338.
2. Yamashita H, Ikematsu H, Murano T, Aoyama N, Kano Y, Mitsui T, Sunakawa H, Shinmura K, Takashima K, Nakajo K, Kadota T, Yoda Y, Yano T. The usefulness of a double-balloon endolumenal interventional platform for colorectal endoscopic submucosal dissection by non-expert endoscopists in a porcine model (with video). Surg Endosc. 2022 Oct;36(10):7818-7826. doi: 10.1007/s00464-022-09338-z.
3. Nakajo K, Yoda Y, Yamashita H, Takashima K, Murano T, Kadota T, Shinmura K, Ikematsu H, Akimoto T, Yano T. Salvage endoscopic resection for cT1N0M0 local recurrence after chemoradiotherapy for esophageal squamous cell carcinoma: endoscopic submucosal dissection versus endoscopic mucosal resection. Jpn J Clin Oncol. 2022 Sep 18;52(9):982-991. doi: 10.1093/jjco/hyac090.
4. Du J, Kageyama SI, Yamashita R, Hirata H, Hakozaki Y, Okumura M, Motegi A, Hojo H, Nakamura M, Hirano Y, Sunakawa H, Minamide T, Kotani D, Tanaka K, Yano T, Kojima T, Ohashi A, Tsuchihara K, Akimoto T. Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation. Cancer Science 113(4):1352-1361. doi: 10.1111/cas.15297.
5. Yamashita H, Kadota T, Minamide T, Sunakawa H, Sato D, Takashima K, Nakajo K, Murano T, Shinmura K, Yoda Y, Ikematsu H, Yano T. Efficacy and safety of second photodynamic therapy for local failure after salvage photodynamic therapy for esophageal cancer. Dig Endosc. 2022 Mar;34(3):488-496. doi: 10.1111/den.14072.
6. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT. SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides. J Biochem. 2022 Jan 7;170(6):699-711. doi: 10.1093/jb/mvab077.

2021年

1. Iwai K., Nambu T., Kashima Y., Yu J., Eng K., Miyamoto K., Kakoi K., Gotou M., Takeuchi T., Kogame A., Murai S., Haeno H., Kageyama S., Kurasawa O., Niu H., Kannan K., and Ohashi A. A CDC7 Inhibitor Suppresses Homologous Recombination Repair to Delay DNA Damage Recovery, and Sensitize DNA-damaging Chemotherapies in Solid Tumors. Science Advances 7: eabf0197. 2021. DOI: 10.1126/sciadv.abf0197
2. Kashima Y.*, Togashi Y.*, Fukuoka S., Kamada T., Irie T., Suzuki A., Nakamura Y., Shitara K., Yoshida T., Taoka N., Kawase T., Wada T., Inaki K., Chihara M., Ebisuno Y., Tsukamoto S., Fujii R., Ohashi A., Suzuki Y., Tsuchihara K., Nishikawa H., and Doi T. *contributed equally. Potentiality of multiple modalities of single-cell analyses to evaluate the tumor microenvironment in clinical specimens. Scientific Reports 11, 341, 2021. doi: 10.s41598-020-79385-w
3. Funasaka C, Naito Y, Kusuhara S, Nakao T, Fukasawa Y, Mamishin K, Komuro A, Okunaka M, Kondoh C, Harano K, Kogawa T, Matsubara N, Hosono A, Kawasaki T, Mukohara T. The efficacy and safety of paclitaxel plus bevacizumab therapy in breast cancer patients with visceral crisis. Breast. 2021 Aug;58:50-56. doi: 10.1016/j.breast.2021.04.001.
4. Mukohara T, Hosono A, Mimaki S, Nakayama A, Kusuhara S, Funasaka C, Nakao T, Fukasawa Y, Kondoh C, Harano K, Naito Y, Matsubara N, Tsuchihara K, Kuwata T. Effects of Ado-Trastuzumab Emtansine and Fam-Trastuzumab Deruxtecan on Metastatic Breast Cancer Harboring HER2 Amplification and the L755S Mutation. Oncologist. 2021 Aug;26(8):635-639. doi: 10.1002/onco.13715.
5. Osaka N, Hirota Y, Ito D, Ikeda Y, Kamata R, Fujii Y, Chirasani VR, Campbell SL, Takeuchi K, Senda T, Sasaki AT. Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. Front Mol Biosci. 2021 Jul 8;8:707439. doi: 10.3389/fmolb.2021.707439.

2020年

1. Fujimoto Y.*, Yamamori-Morita T.*, Ohashi A., Haeno H., Hakozaki Y., Fujii M., Kashima Y., Kobayashi S.S., and Mukohara T. *contributed equally. Combination treatment with a phosphoinositide 3-kinase inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant human epidermal growth factor receptor 2-positive breast cancer cells. Scientific Reports 10, 21762, 2020. doi: 10.1038/s41598-020-78646-y
2. Wolfe K, Kamata R, Coutinho K, Inoue T, Sasaki AT. Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells. Front Oncol. 2020 Nov 2;10時55分4272. doi: 10.3389/fonc.2020.554272.
3. Watanabe S, Usui-Kawanishi F, Komada T, Karasawa T, Kamata R, Yamada N, Kimura H, Dezaki K, Ohmori T, Takahashi M. ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. Biochem Biophys Res Commun. 2020 Oct 15;531(2):125-132. doi: 10.1016/j.bbrc.2020.07.063.
4. Ito H, Kimura H, Karasawa T, Hisata S, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Komada T, Watanabe S, Kasahara T, Suzuki T, Horie H, Kitayama J, Sata N, Yamaji-Kegan K, Takahashi M. NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury. J Immunol. 2020 Sep 1;205(5):1393-1405. doi: 10.4049/jimmunol.2000217.
5. Tsumura R., Koga Y., Hamada A., Kuwata T., Sasaki H., Doi T., Aikawa K., Ohashi A., Katano I., Ikarashi Y., Ito M., and Ochiai A. The report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan. Cancer Science 111(9):3386-3394. 2020. doi: 10.1111/cas.14564.
6. Sakamoto Y., Xu L., Seki1 M., Toshiyuki T. Yokoyama T.T., Masahiro, Kasahara M., Kashima Y., Ohashi A., Shimada Y., Motoi N., Tsuchihara K., Kobayashi S., Kohno T., Shiraishi Y., Suzuki A., and Suzuki Y. Long read sequencing for non-small cell lung cancer genomes. Genome Research 30 (9):1243-1257. 2020. doi: 10.1101/gr.261941.120.
7. Kurasawa O., Miyazaki T., Homma M., Oguro Y., Imada T., Uchiyama N., Iwai K., Yamamoto Y., Ohori M., Hara H., Sugimoto H., Iwata K., Skene R., Hoffman ID., Ohashi A., Nomura T., and Cho N. Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent. J Med Chem. 2020 doi: 10.1021/acs.jmedchem.9b01427
8. Maruyama T, Sasaki A, Iijima S, Ayukawa S, Goda N, Tazuru K, Hashimoto N, Hayashi T, Kozawa K, Sato N, Ishikawa S, Morita T, Fujita Y. ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition. iScience. 2020 Jul 24;23(7):101327. doi: 10.1016/j.isci.2020.101327.
9. Aizawa E, Karasawa T, Watanabe S, Komada T, Kimura H, Kamata R, Ito H, Hishida E, Yamada N, Kasahara T, Mori Y, Takahashi M. GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition. iScience. 2020 May 22;23(5):101070. doi: 10.1016/j.isci.2020.101070.
10. Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C, Watanabe S, Kamata R, Ohno N, Takahashi M. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H508-H518. doi: 10.1152/ajpheart.00559.2019.
11. Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, Komada T, Inoue Y, Mise N, Kasahara T, Takahashi M. Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages. J Cell Physiol. 2020 Oct;235(10):7554-7566. doi: 10.1002/jcp.29659.
12. Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S, Mizuta K, Sakuma Y, Sata N, Takahashi M. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis. 2020 Feb 24;11(2):144. doi: 10.1038/s41419-020-2334-2.
13. Nakajima T, Kasuga A, Hara-Yamashita A, Ikeda Y, Asai-Sato M, Nakao T, Hayashi C, Takeya C, Adachi K, Tsuruga T, Matsumoto Y, Arimoto T, Nagamatsu T, Oda K, Komatsu A, Chishima F, Osuga Y, Fujii T, Kawana K. Reconstructed uterine length is critical for the prevention of cervical stenosis following abdominal trachelectomy in cervical cancer patients. J Obstet Gynaecol Res. 2020 Feb;46(2):328-336. doi: 10.1111/jog.14153.
14. Yamada N, Karasawa T, Wakiya T, Sadatomo A, Ito H, Kamata R, Watanabe S, Komada T, Kimura H, Sanada Y, Sakuma Y, Mizuta K, Ohno N, Sata N, Takahashi M. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis. Am J Transplant. 2020 Jun;20(6):1606-1618. doi: 10.1111/ajt.15773.

2019年

1. Udagawa H, Hasako S, Ohashi A, Fujioka R, Hakozaki Y, Shibuya M, et al. TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically-relevant EGFR mutations. Mol Cancer Res. 2019. Epub 2019年08月31日. doi: 10.1158/1541-7786.
2. Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitayama J, Sata N, Takahashi M. Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury. Biochem Biophys Res Commun. 2019 Oct 29;519(1):15-22. doi: 10.1016/j.bbrc.2019.08.083.
3. Ryo Kamata, Masafumi Takahashi. Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm. J Jpn Coll Angiol; 59: 83–87 2019
4. Yamashita H, Kurita A, Azuma S, Kudo Y, Matsuzaki N, Yazumi S. Usefulness of immunohistochemical staining for MUC5AC in differentiating primary pancreatic cancer from pancreatic metastasis of breast cancer. Diagn Cytopathol. 2019 Oct;47(10):1037-1041. doi: 10.1002/dc.24249.
5. Ikeda Y, Uemura Y, Asai-Sato M, Nakao T, Nakajima T, Iwata T, Akiyama A, Satoh T, Yahata H, Kato K, Maeda D, Aoki D, Kawana K. Safety and efficacy of mucosal immunotherapy using human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of high-grade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-controlled clinical trial (MILACLE study). Jpn J Clin Oncol. 2019 Sep 1;49(9):877-880. doi: 10.1093/jjco/hyz095.
6. Hishida E, Ito H, Komada T, Karasawa T, Kimura H, Watanabe S, Kamata R, Aizawa E, Kasahara T, Morishita Y, Akimoto T, Nagata D, Takahashi M. Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis. Sci Rep. 2019 Jul 17;9(1):10363. doi: 10.1038/s41598-019-46504-1.
7. Kashima Y, Suzuki A, Suzuki Y. An Informative Approach to Single-Cell Sequencing Analysis. Adv Exp Med Biol. 2019;1129:81-96. Epub 2019年04月11日. doi: 10.1007/978-981-13-6037-4_6.
8. Iwai K, Nambu T, Dairiki R, Ohori M, Yu J, Burke K, Gotou M, Yamamoto Y, Ebara S, Shibata S, Hibino R, Nishizawa S, Miyazaki T, Homma M, Oguro Y, Imada T, Cho N, Uchiyama N, Kogame A, Takeuchi T, Kurasawa O, Yamanaka K, Niu H, Ohashi A. Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor. Sci Adv. 2019;5(5):eaav3660. Epub 2019年05月28日. doi: 10.1126/sciadv.aav3660.
9. Ikemura S, Yasuda H, Matsumoto S, Kamada M, Hamamoto J, Masuzawa K, Kobayashi K, Manabe T, Arai D, Nakachi I, Kawada I, Ishioka K, Nakamura M, Namkoong H, Naoki K, Ono F, Araki M, Kanada R, Ma B, Hayashi Y, Mimaki S, Yoh K, Kobayashi SS, Kohno T, Okuno Y, Goto K, Tsuchihara K, Soejima K. Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations. Proc. Natl. Acad. Sci. USA. 2019;116(20):10025-30. Epub 2019年05月03日. doi: 10.1073/pnas.1819430116.
10. Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M. Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration-Induced Acute Lung Injury. J Immunol. 2019 Jul 1;203(1):236-246. doi: 10.4049/jimmunol.1900168.