Selected Publications

Obata Y (corresponding author), Kurokawa K, Tojima T, Natsume M, Shiina I, Takahashi T, Abe R, Nakano A & Nishida T.Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. Cell Reports, 42, 113035 (2023). https://doi.org/10.1016/j.celrep.2023.113035

*Natsume M, *Niwa M, Ichikawa S, Okamoto T, Tsutsui H, Usukura D, Murata T, Abe R, Shimonaka M, Nishida T, Shiina I & Obata Y (corresponding author). Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5. bioRxiv (2023, *Equal Contribution). https://doi.org/10.1101/2023.10.11.558504

Teranishi R, Takahashi T, Obata Y, Nishida T, Okubo S, Kazuno H, Saito Y, Serada S, Fujimoto M, Kurokawa Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Hirota S, Naka T, Eguchi H & Doki Y. Combination of pimitespib (TAS-116) with sunitinib is an effective therapy for imatinib-resistant gastrointestinal stromal tumors. Int. J. Cancer, 152, 2580-2593 (2023). https://doi.org/10.1002/ijc.34461

Miyazaki T, Chung S, Sakai H, Ohata H, Obata Y, Shiokawa D, Mizoguchi Y, Kubo T, Ichikawa H, Taniguchi H, Aoki K, Soga T, Nakagama H & Okamoto K. Stemness and immune evasion conferred by TDO2-AHR pathway drive liver metastasis of colon cancer. Cancer Science, 113, 170-181 (2022). https://doi.org/10.1111/cas.15182

Yamawaki K, Shiina I, Murata T, Tateyama S, Maekawa Y, Niwa M, Shimonaka M, Okamoto K, Suzuki T, Nishida T, Abe R & Obata Y (corresponding author). FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells. Scientific Reports, 11, 22678 (2021). https://doi.org/10.1038/s41598-021-02221-2

Saito Y, Takahashi T, Obata Y, Nishida T, Ohkubo S, Nakagawa F, Serada S, Fujimoto M, Ohkawara T, Nishigaki T, Sugase T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Hirota S, Naka T, Mori M & Doki Y. TAS-116 inhibits oncogenic KIT signaling on the Golgi in both imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. British J. Cancer, 122, 658-667 (2020). https://doi.org/10.1038/s41416-019-0688-y

Obata Y (corresponding author), Hara Y, Shiina I, Murata T, Tasaki Y, Suzuki K, Ito K, Tsugawa S, Yamawaki K, Okamoto K, Nishida T & Abe R. N822K- or V560G-mutated KIT activation occurs preferentially in lipid rafts of the Golgi apparatus in leukemia cells. Cell Commun. & Signal. 17, 114 (2019). https://doi.org/10.1186/s12964-019-0426-3

Ohata H, Shiokawa D, Obata Y, Sato A, Sakai H, Fukami M, Hara W, Taniguchi H, Ono M, Nakagama H & Okamoto K. NOX1-dependent mTORC1 activation via S100A9 oxidation in cancer stem-like cells leads to colon cancer progression. Cell Reports, 28, 1282-1295 (2019). https://doi.org/10.1016/j.celrep.2019.06.085

Obata Y, Horikawa K, Shiina I, Takahashi T, Murata T, Tasaki Y, Suzuki K, Yonekura K, Esumi H, Nishida T & Abe R. Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in GISTs. Cancer Letters, 415, 1-10 (2018). https://doi.org/10.1016/j.canlet.2017.11.032

Obata Y, Horikawa K, Takahashi T, Akieda Y, Tsujimoto M, Fletcher JA, Esumi H, Nishida T & Abe R. Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors. Oncogene, 36, 3661-3672 (2017, Featured Article). https://doi.org/10.1038/onc.2016.519

Hara Y, Obata Y (corresponding author), Horikawa K, Tasaki Y, Suzuki K, Murata T, Shiina I & Abe R. M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells. PLOS ONE, 12, e0175514 (2017). https://doi.org/10.1371/journal.pone.0175514

Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, Matsumoto S, Sugiyama E, Ochiai A, Abe R, Goto K, Esumi H & Tsuchihara K. Signaling through the PI3K/mTOR axis is responsible for aerobic glycolysis mediated by glucose transporter in EGFR-mutated lung adenocarcinoma. J. Biol. Chem. 290, 17495-17504 (2015). https://doi.org/10.1074/jbc.M115.660498

Obata Y, Toyoshima S, Wakamatsu E, Suzuki S, Ogawa S, Esumi H & Abe R. Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation. Nature Communications, 5, 5715 (2014). https://doi.org/10.1038/ncomms6715

Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N & Yamaguchi N. The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J. Cell Sci. 123, 2649-2662 (2010). https://doi.org/10.1242/jcs.066266

Fukumoto Y, Obata Y, Ishibashi K, Kikuchi I, Tamura N, Aoyama K, Hattori Y, Tsuda K, Nakayama Y & Yamaguchi N. Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine. Cytotechnology, 62, 73-82 (2010). https://doi.org/10.1007/s10616-010-9259-z

*Sato I, *Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T & Yamaguchi N. Differential trafficking of c-Src, Lyn, c-Yes, and Fyn is specified by the state of palmitoylation in the SH4 domain. J. Cell Sci. 122, 965-975 (2009, *Equal Contribution). https://doi.org/10.1242/jcs.034843

Takahashi A, Obata Y, Fukumoto Y, Nakayama Y, Kasahara K, Kuga T, Higashiyama Y, Saito T, Yokoyama KK & Yamaguchi N. Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Exp. Cell Res. 315, 1117-1141 (2009). https://doi.org/10.1016/j.yexcr.2009.02.010