1. Kana Shimomura, Naoko Hattori, Naoko Iida, Yukari Muranaka, Kotomi Sato, Yuichi Shiraishi, Yasuhito Arai, Natsuko Hama, Tatsuhiro Shibata, Daichi Narushima, Mamoru Kato, Hiroyuki Takamaru, Koji Okamoto, Haruna Takeda*. Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development. Nature Communications 14(1) 2023, *corresponding author
   DOI: https://doi.org/10.1038/s41467-023-42228-z
2. Kazuhiro Nishiyama, Hitomi Nishinakamura, Hideyuki Takeshima, Liu Yuyu, Chihiro Takeuchi, Naoko Hattori, Haruna Takeda, Satoshi Yamashita, Mika Wakabayashi, Kotomi Sato, Kazutaka Obama, Toshikazu Ushijima. Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples. PLOS ONE 18(10) e0290034-e0290034 2023
3. Yamamoto D, Oshima H, Wang D, Takeda H, Kita K, Lei X, Nakayama M, Murakami K, Ohama T, Takemura H, Toyota M, Suzuki H, Inaki N and Oshima M. Characterization of RNF43 frameshift mutations that drive Wnt ligand- and R-spondin-dependent colon cancer. J. Pathol. 257, 2022
4. Haruna Takeda*. A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids. Front. Genet. 12, 2021, *corresponding author
5. Takeda H*, Jenkins NA and Copeland NG. Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis. Review, Cancer Science, 112(6):2089-2096, 2021 *corresponding author
6. Murakami K, Terakado Y, Saito K, Jomen Y, Takeda H, Oshima M et al. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. PNAS, 118, 2021.
7. Takeda H*, Kataoka S, Nakayama M, Ali MAE, Oshima H, Yamamoto D et al. CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes. PNAS, 116: 15635-15644, 2019. *corresponding author
8. Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE et al. p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. J Clin Invest, 127: 4462-4476, 2017.
9. Takeda H and Kiyokawa E. Activation of Erk in ilieal epithelial cells engaged in ischemic-injury repair. Sci Rep, 469-16481, 2017
10. Takeda H, Rust AG, Ward JM, Yew CC, Jenkins NA, Copeland NG. Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development. PNAS, 113: E2057-2065, 2016.
11. Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB et al. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression. Nature genetics, 47: 142-150, 2015.
12. Takeda H, Koso H, Tessarollo L, Copeland NG, Jenkins NA. Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells. Genesis, 51: 128-134, 2013.
13. Koso H, Takeda H, Yew CC, Ward JM, Nariai N, Ueno K et al. Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells. PNAS, 109: E2998-3007, 2012.
14. Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene, 25: 1816-1820, 2006.
15. Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM. Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. British journal of cancer, 90: 701-704, 2004.
16. Takeda H, Sonoshita M, Oshima H, Sugihara K, Chulada PC, Langenbach R et al. Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer research, 63: 4872-4877, 2003.

日本語雑誌

1. 武田はるな　「CRISPR-Cas9と消化管由来オルガノイドを用いた大腸がんドライバー遺伝子の機能検証」消化器病学サイエンスVol.4, no.1, 2020, 55-58
2. 武田はるな　「トランスポゾン挿入変異を用いたがん形成に関与する遺伝子の同定」金沢医科大学雑誌　2015年第40巻　第2・3合併号