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トップページ > 研究組織一覧 > 分野・独立ユニットグループ > 新領域創成プロジェクトグループ > 分子薬理研究分野 > 論文業績

論文業績

  1. Nishidate M, Yamamoto K, Masuda C, Aikawa H, Hayashi, Kawanishi T, Hamada A. MALDI mass spectrometry imaging of erlotinib administered in combination with bevacizumab in xenograft mice bearing B901L, EGFR-mutated NSCLC cells. Sci Rep. 7(1):16763(2017). PMID: 29196706
  2. Iwamoto N, Hamada A, Shimada T. Antibody drug quantitation in coexistence with anti-drug antibodies on nSMOL bioanalysis. Anal Biochem, 9;540-541:30-37(2017). PMID: 29128290
  3. Ryu S, Hayashi M, Aikawa H, Okamoto I, Fujiwara Y, Hamada A. Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study. Br J Pharmacol, doi: 10.1111/bph.14067(2017). PMID: 29027209
  4. Tsubata Y, Hayashi M, Tanino R, Aikawa H, Ohuchi M, Tamura K, Fujiwara Y, Isobe T, Hamada A. Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging. Sci Rep, 7(1):12622(2017). PMID: 28974758
  5. Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayashi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H. Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs. Antiviral Res, 8;149:78-88(2017). PMID: 28893602
  6. Tsuchiya K, Hayashida T, Hamada A, Oki S, Oka S, Gatanaga H. High plasma concentrations of dolutegravir in patients with ABCG2 genetic variants. Pharmacogenet Genomics, 27(11):416-419(2017). PMID: 28858994
  7. Sasada S, Kurihara H, Kinoshita T, Yoshida M, Honda N, Shimoi T, Shimomura A, Yonemori K, Shimizu C, Hamada A, Kanayama Y, Watanabe Y, Fujiwara Y, Tamura K. Visualization of HER2-specific breast cancer intratumoral heterogeneity using 64Cu-DOTA-trastuzumab PET. Eur J Nucl Med Mol Imaging, 44(12):2146-2147(2017). PMID: 28770275
  8. Tsuchiya K, Ohuchi M, Yamane N, Aikawa H, Gatanaga H, Oka S, Hamada A. High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of raltegravir, dolutegravir and elvitegravir concentrations in human plasma and cerebrospinal fluid samples. Biomed Chromatogr, doi: 10.1002/bmc.4058(2017). PMID: 28762239
  9. Iwamoto N, Shimomura A, Tamura K, Hamada A, Shimada T. LC-MS bioanalysis of Trastuzumab and released emtansine using nano-surface and molecular-orientation limited (nSMOL) proteolysis and liquid-liquid partition in plasma of Trastuzumab emtansine-treated breast cancer patients. J Pharm Biomed Anal, 25;145:33-39(2017). PMID: 28648785
  10. Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y. Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese. Cancer Chemother Pharmacol, 79(6):1179-1186(2017). PMID: 28447211
  11. Iwama E, Goto Y, Murakami H, Harada T, Tsumura S, Sakashita H, Mori Y, Nakagaki N, Fujita Y, Seike M, Bessho A, Ono M, Okazaki A, Akamatsu H, Morinaga R, Ushijima S, Shimose T, Tokunaga S, Hamada A, Yamamoto N, Nakanishi Y, Sugio K, Okamoto I. Alectinib for Patients with ALK Rearrangement-Positive Non-Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401). J Thorac Oncol,  12(7):1161-1166(2017). PMID: 28238961
  12. Tamura T, Hirata T, Tabata M, Hinotsu S, Hamada A, Motoki T, Iwamoto T, Mizoo T, Nogami T, Shien T, Taira N, Matsuoka J, Doihara H. A Phase I Trial of 100 mg/m2 Docetaxel in Patients with Advanced or Recurrent Breast Cancer. Acta Med Okayama. 70(5):425-427(2016). PMID: 27777441
  13. Hirayama M, Tomita Y, Yuno A, Tsukamoto H, Senju S, Imamura Y, Sayem MA, Irie A, Yoshitake Y, Fukuma D, Shinohara M, Hamada A, Jono H, Yuba E, Kono K, Yoshida K, Tsunoda T, Nakayama H, Nishimura Y. An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs. Oncoimmunology. 4;5(6):e1123368(2016). PMID: 27471607
  14. Fujiwara Y, Hamada A, Mizugaki H, Aikawa H, Hata T, Horinouchi H, Kanda S, Goto Y, Itahashi K, Nokihara H, Yamamoto N, Ohe Y. Pharmacokinetic profiles of significant adverse events with crizotinib in Japanese patients with ABCB1 polymorphism, Cancer Sci, 107:1117-23(2016). PMID: 27270784
  15. Iwamoto N, Shimada T, Terakado H, Hamada A. Validated LC-MS/MS analysis of immune checkpoint inhibitor Nivolumab in human plasma using a Fab peptide-selective quantitation method: nano-surface and molecular-orientation limited (nSMOL) proteolysis. J Chromatogr B Analyt Technol Biomed Life Sci. 27;1023-1024:9-16 (2016). PMID: 27155936
  16. Yamagishi M, Tsuta K, Shimoi T, Tanabe Y, Hirai M, Kohno T, Shiraishi K, Nakaoku T, Sunami K, Shimada Y, Tamura K, Hamada A.  Automated and rapid system for detection of ALK rearrangement genes in non-small cell lung cancer based on a Quenching Probe method,  Biomed Res Clin Prac, 1:36-41(2016).
  17. Iwamoto N, Takanashi M, Hamada A, Shimada T. Validated LC/MS bioanalysis of Rituximab CDR peptides using nano-surface and molecular-orientation limited (nSMOL) proteolysis. Biol Pharm Bull. 2016(accepted). PMID: 27150271
  18. Tsuchiya K, Hayashida T, Hamada A, Oka S, Gatanaga H. Brief Report: High Peak Level of Plasma Raltegravir Concentration in Patients With ABCB1 and ABCG2 Genetic Variants. J Acquir Immune Defic Syndr. 72(1):11-4(2016). PMID: 27097364
  19. Aikawa H, Hayashi M, Ryu S, Yamashita M, Ohtsuka N, Nishidate M, Fujiwara Y, Hamada A.  Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging, Sci Rep, 30;6:23749(2016). PMID: 27026287
  20. Iwamoto N, Takanashi M, Umino Y, Aoki C, Hamada A, Shimada T. Application of nano-surface and molecular-orientation limited proteolysis to LC-MS bioanalysis of cetuximab. Bioanalysis. 8:1009-1020(2016). PMID: 26972866
  21. Iwamoto N, Umino Y, Aoki C, Yamane N, Hamada A, Shimada T. Fully validated LCMS bioanalysis of Bevacizumab in human plasma using nano-surface and molecular-orientation limited (nSMOL) proteolysis. Drug Metab Pharmacokinet. 31(1):46-50(2016). PMID: 26830079
  22. Yamashita M, Kitano S, Aikawa H, Kuchiba A, Hayashi M, Yamamoto N, Tamura K, Hamada A.  A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flowcytometry using cryopreserved human peripheral blood mononuclear cells, Sci Rep. 27;6:19772 (2016). PMID: 26813960
  23. Kurihara H, Shimizu C, Miyakita Y, Yoshida M, Hamada A, Kanayama Y, Yonemori K, Hashimoto J, Tani H, Kodaira M, Yunokawa M, Yamamoto H, Watanabe Y, Fujiwara, Y, Tamura K. Molecular imaging using PET for breast cancer. Breast Cancer. 23(1):24-32(2016). PMID: 25917108
  24. Hayashi M, Yamamoto Y, Sueta A, Tomiguchi M, Yamamoto-Ibusuki M, Kawasoe T, Hamada A, Iwase H. Associations Between Elastography Findings and Clinicopathological Factors in Breast Cancer Medicine (Baltimore). 2015 Dec;94(50):e2290. PMID: 26683963
  25. Fujiwara Y,  Kobayashi S, Nagano H, Kanai M, Hatano E, Toyoda M, Ajiki T, Takashima Y, Hamada A, Minami H, Ioka T. Pharmacokinetic Study of Adjuvant Gemcitabine Therapy for Biliary Tract Cancer following Major Hepatectomy (KHBO1101), PLO S ONE, 3;10(12):e0143072(2015). PMID: 26633034
  26. Otani S, Hamada A, Sasaki J, Wada M, Yamamoto M, Ryuge S, Takakura A, Fukui T, Yokoba M, Mitsufuji H, Toyooka T, Maki S, Kimura M, Hayashi N, Ishihara M, Kasajima M, Hiyoshi Y, Nagashima Y, Katono K, Igawa S, Kubota M, Katagiri M, Saito H, Masuda N. Phase I and Pharmacokinetic Study of Erlotinib Administered in Combination With Amrubicin in Patients With Previously Treated, Advanced Non-Small Cell Lung Cancer. Am J Clin Oncol, 38:405-10(2015). PMID: 26214085
  27. Iwamoto N, Umino Y, Yamane N, Hamada A, Shimada T. Development of the validated LCMS bioanalysis of Trastuzumab in human plasma using selective detection method for complementarity-determining regions of monoclonal antibody: nano-surface and molecular-orientation limited (nSMOL) proteolysis, Analytical Methods, 7: 9177-9183(2015).
  28. Katsuya Y, Fujiwara Y, Sunami K, Utsumi H, Goto Y, Kanda S, Horinouchi H, Nokihara H, Yamamoto N, Takashima Y, Osawa S, Ohe Y, Tamura T, Hamada A. Comparison of the pharmacokinetics of erlotinib administered in complete fasting and 2 h after a meal in patients with lung cancer. Cancer Chemother Pharmacol, 76:125-32(2015). PMID: 25994853
  29. Oguri T, Shimokata T, Ito I, Yasuda Y, Sassa N, Nishiyama M, Hamada A, Hasegawa Y, Ando Y. Extension of the Calvert formula to patients with severe renal insufficiency, Cancer Chemo Phamacol, 76:53-9(2015). PMID: 25957958
  30. Kurihara H, Hamada A, Yoshida M, Shimma S, Hashimoto J, Yonemori K, Tani H, Miyakita Y, Kanayama Y, Wada Y, Kodaira M, Yunokawa M, Yamamoto H, Shimizu C, Takahashi K, Watanabe Y, Fujiwara Y, Tamura K. 64Cu-DOTA-trastuzumab PET imaging and HER2-specificity of brain metastases in HER2-positive breast cancer patients. EJNMMI Research, 5:8(2015). PMID: 25853014
  31. Yoshitake Y, Fukuma D, Yuno A, Hirayama M, Nakayama H, Tanaka T, Nagata M, Takamune Y, Kenta Kawahara K, Nakagawa Y, Yoshida R, Hirosue A, Ogi H, Hiraki A, Jono H, Hamada A, Yoshida K, Nishimura Y, Nakamura Y, Shinohara M. Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS, Clin Cancer Res, 21:312-21(2015). PMID: 25391695
  32. Sakata S, Sasaki S, Saeki S, Hamada A, Kishi H, Nakamura K, Notsute D, Sato R, Saruwatari K, Iriki T, Tanaka H, Akaike K, Fujii S, Hirosako S, Kohrogi H. Dose escalation and pharmacokinetic study of carboplatin plus pemetrexed for elderly patients with advanced non-squamous, non-small-cell lung cancer: Kumamoto Thoracic Oncology Study Group Trial 1002, Oncology, 88:201-207(2015). PMID: 25502447
  33. Yagishita S, Hamada A. Clinical pharmacology of EGFR/Met inhibitors in non-small cell lung cancer, Current Drug Target, 21:312-321(2014). PMID: 25382203
  34. Yamakawa Y, Hamada A, Uchida T, Sato D, Yuki M, Hayashi M, Kawaguchi T, Saito H. Distinct Interaction of Nilotinib and Imatinib with P-Glycoprotein in Intracellular Accumulation and Cytotoxicity in CML Cell Line K562 Cells. Biol Pharm Bull. 37(8):1330-5 (2014). PMID: 25087954
  35. Hirakawa A, Yonemori K, Kuwatsuka Y, Kodaira M, Yamamoto H, Yunokawa M, Hamada A, Shimizu C, Tamura K, Gemma A, Fujiwara Y. A Descriptive Analysis of Post-Chemotherapy Development of Interstitial Lung Disease using Spontaneous Reporting Data in Japan. Curr Drug Saf. 9:220-226(2014). PMID: 24909577
  36. Tuchiya K, Hayashida T, Hamada A, Kato S, Oka S, Gatanaga H. Low raltegravir concentration in cerebrospinal fluid in patients with ABCG2 genetic variants, J Acquir Immune Defic Syndr, 166:484-486(2014). PMID: 24872134
  37. Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Imamura Y, Yatsuda J, Sayem MA, Irie A, Hamada A, Jono H,Yoshida K, Tsunoda T, Daigo Y, Kohrogi H, Yoshitake Y, NakamuraY, Shinohara M, Nishimura Y. LY6K-specific CD4+ T-cell immunity in patients with malignant tumor: Identification of LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes. OncoImmunology, 3:e28100, 2014. PMID: 25340007
  38. Tomita Y, Yuno A, Tsukamoto H, Senju S, Yoshimura S, Osawa R, KurodaY, Hirayama M, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y. Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. Int. J. Cancer 134: 352-366, 2014. PMID: 24734272
  39. Iwamoto N, Umino Y, Aoki C, Aoki Y, Sato T, Hamada A, Shimada T. Identification and quantitation for complementarity-determining regions of monoclonal antibody by nano-surface and molecular-orientation limited proteolysis. Analyst, 139:576-580(2014).
  40. Harada T, Hamada A, Shimokawa M, Takayama K, Kudoh S, Sato S, Saeki S, Miyawaki H, Moriyama A, Nakagawa K, Nakanishi Y. Phase I/II tiral of irrinotecan plus amurubicine supported with G-CSF for extended small cell lung cancer, Jpn J Clin Oncol, 44:127-133(2014). PMID: 24379211
  41. Shimma S, Takashima Y, Hashimoto J, Yonemori K, Tamura K, Hamada A. Alternative two-stepmatrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency. J Mass Spectrom, 48:1285-1290 (2013). PMID: 24338883
  42. Yatsuga C, Toyohisa D, Fujisawa TX, Nishitani S, Shinohara K, Matsuura N, Ikeda S, Muramatsu M, Hamada A, Tomoda A. No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children. Brain Dev. 36:620-625(2014). PMID: 24035255
  43. Hashiguchi Y, Hamada A, Shinohara T, Tsuchiya K, Jono H, Saito H. Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents. Biochem Biophys Res Commun. 439:221-227(2013). PMID: 23981805
  44. Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Irie A, Kawahara K, Yatsuda J, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y; Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor. Clin. Cancer Res. 19:4508-4520(2013). PMID: 23714729
  45. Tsubata Y, Okimoto T, Miura K, Karino F, Iwamoto S, Suzuki T, Hamaguchi S, Kanda H. Sutani A, Kuraki T, Hamada A, Isobe T. Phase I clinical and pharmacokinetics study of bi-weekly carboplatin/paclitaxel chemotherapy in aged patients with non-small-cell lung cancer, Anticancer Research, 33:261-266(2013). PMID: 23267154
  46. Tsubata Y, Hamada A, Sutani A, and Isobe T. Erlotinib-induced acute interstitial lung disease associated with extreme elevation of the plasma concentration in an elderly non-small-cell lung cancer patient, Journal of Cancer Research and Therapeutics, 8: 154-156(2012). PMID: 22531540
  47. Hamada A, Sasaki J, Saeki S, Iwamoto N, Inaba M, Ushijima S, Urata M, Kishi H, Fujii S, Semba H, Kashiwabara K, Tsubata Y, Kai Y, Isobe T, Kourogi H, Saito H. Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small cell lung cancer, Pharmacogenomics, 13:615-624(2012). PMID: 22462752
  48. Kato T, Hamada A, Mori S, Saito H. Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis, Drug Metab Pharmacokinet, 27:192-199(2012). PMID: 22104130
  49. Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, Yoshimura M, Hamada A, Saito H. Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events. Clin Exp Nephrol. 16:843-851(2012). PMID: 22569819

 

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医薬品開発における質量分析イメージング技術利用に関するリフレクションペーパー(2016年度)