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分譲可能な肉腫細胞株

提供可能な肉腫細胞株

2020.06.05更新

# Cancer type ID Original tumor type Comments(histology, fusion gene, ets) Ref
1 Leiomyosarcoma NCC-LMS1-C1 PDC These cell lines were established from tumors of leiomyosarcoma of bone. The details of this case were reported in reference 1 and 2. 1
2 NCC-LMS1-X3-C1 PDX 2
3 Undifferentiated pleomorphic sarcoma (UPS) NCC-UPS1-C1 PDC   3
4 NCC-UPS1-X3-C1 PDX   4
5 NCC-UPS2-C1 PDC   5
6 NCC-UPS3-C1 PDC   in preparation
7 NCC-UPS4-C1 PDC   in preparation
8 Malignant peripheral nerve sheath tumor(MPNST)

NCC-MPNST1-C1

PDC   6
9 NCC-MPNST2-C1 PDC These cell line was established from tumors of MPNST of bone. 6
10 NCC-MPNST3-C1 PDC   6
11 NCC-MPNST3-X2-C1 PDX   6
12 NCC-MPNST4-C1 PDC   6
13 NCC-MPNST5-C1 PDC   6
14 Osteosarcoma

NCC-OS1-C1

PDC conventional osteosarcoma 7
15 NCC-ESOS1-C1 PDC extraskeletal osteosarcoma 8
16 Clear cell sarcoma NCC-CCS1B-C1 PDC EWSR1-ATF1 fusion gene 9
17 NCC-CCS1B-X2-C1 PDX EWSR1-ATF1 fusion gene 9
18 NCC-CCS1-X4-C1 PDX EWSR1-ATF1 fusion gene 9
19 CIC-DUX4 NCC-CDS1-X1-C1 PDX CIC-DUX4 fusion gene 10
20 NCC-CDS1-X3-C1 PDX CIC-DUX4 fusion gene. 10
21 NCC-CDS2-C1 PDC CIC-DUX4 fusion gene. 11
22 Rhabdomyosarcoma NCC-pRMS1-C1 PDC pleomorphic rhabdomyosarcoma 12
23 NCC-pRMS-X4-C1 PDX pleomorphic rhabdomyosarcoma 12
24 NCC-ssRMS1-C1 PDC spindle-cell/sclerosing rhabdomyosarcoma 13
25 NCC-aRMS1-C1 PDC alveolar rhabdomyosarcoma in preparation
26 Synovial sarcoma NCC-SS1-C1 PDC SYT-SSX1 fusion gene 14
27 NCC-SS2-C1 PDC SYT-SSX2 fusion gene 15
28 NCC-SS3-C1 PDC SYT-SSX1 fusion gene 16
29 Dermatofibrosarcoma protuberans (DFSP) NCC-DFSP1-C1 PDC COL1A1(exon 33)-PDGFB(exon 2) fusion gene 17
30 NCC-DFSP2-C1 PDC COL1A1(exon 42)-PDGFB(exon 2) fusion gene 17
31 NCC-DFSP3-C1 PDC COL1A1(exon 25)-PDGFB(exon 2) fusion gene 18
32 Myxofibrosarcoma NCC-MFS1-C1 PDC   19
33 NCC-MFS2-C1 PDC   in preparation
34 Ewing's sarcoma NCC-ES1-C1 PDC EWSR1-FLI1 fusion gene 20
35 Chondrosarcoma NCC-dCS1-C1 PDC dedifferentiated chondrosarcoma 21
36 NCC-dCS2-C1 PDC dedifferentiated chondrosarcoma in preparation
37 Alveolar soft part sarcoma (ASPS) NCC-ASPS1-C1 PDC ASPL-TFE3 fusion gene submitted
38 Giant cell tumor of bone (GCTB) NCC-GCTB1-C1 PDC giant cell tumor of bone. H3F3A mutation in preparation
39 NCC-GCTB2-C1 PDC giant cell tumor of bone. H3F3A mutation in preparation
40 NCC-GCTB3-C1 PDC giant cell tumor of bone. H3F3A mutation in preparation
41 NCC-TGCTB1-C1 PDC Tenosynovial giant cell tumor. COL6A3-CSF1 fusion gene in preparation
42 Liposarcoma NCC-MLS1-C1 PDC Myxoid liposarcoma. FUS-CHOP fusion gene submitted
43 NCC-DDLS1-C1 PDC Dedifferentiated liposarcoma. MDM2 amplifiacation in preparation
44 NCC-DDLS2-C1 PDC Dedifferentiated liposarcoma. MDM2 amplifiacation in preparation
45 NCC-PLS1-C1 PDC Pleomorphic liposarcoma in preparation

References

  1. Sakumoto M, Takahashi M, Oyama R, Takai Y, Kito F, Shiozawa K, Qiao Z,Yoshida A, Endo M, Kawai A, Kondo T. stablishment and proteomic characterization of NCC-LMS1-C1, a novel cell line of primary leiomyosarcoma of the bone. Jpn J Clin Oncol. 2017 Oct 1;47(10):954-961. doi: 10.1093/jjco/hyx096. PMID: 28981730.[PubMed](external link)

  2.  Oyama R, Takahashi M, Kito F, Sakumoto M, Shiozawa K, Qiao Z, Yoshida A, Endo M, Kawai A, Kondo T. Establishment and characterization of patient-derived xenograft and its cell line of primary leiomyosarcoma of bone. In Vitro Cell Dev Biol Anim. 2018 Jun;54(6):458-467. doi: 10.1007/s11626-018-0258-2. Epub 2018 May 29. PMID: 29845452.[PubMed](external link)
  3. Tiss. Cult. Res. Commun. (2017) 36, 41-48. [J-Stage](external link)
  4. Tiss. Cult. Res. Commun. (2018) 37, 1–13. [J-Stage](external link)
  5. Oyama R, Kito F, Sakumoto M, Shiozawa K, Toki S, Yoshida A, Kawai A, Kondo T. Establishment and proteomic characterization of a novel cell line, NCC-UPS2-C1, derived from a patient with undifferentiated pleomorphic sarcoma. In Vitro Cell Dev Biol Anim. 2018 Mar;54(3):257-263. doi:10.1007/s11626-018-0229-7. Epub 2018 Jan 22. PMID:29359268.[PubMed](external link)
  6. Oyama R, Kito F, Takahashi M, Hattori E, Noguchi R, Takai Y, Sakumoto M, Qiao Z, Toki S, Sugawara M, Tanzawa Y, Kobayashi E, Nakatani F, Iwata S, Yoshida A, Kawai A, Kondo T. Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. Cancer Cell Int. 2020 Feb 19;20:58. doi: 10.1186/s12935-020-1128-z. PMID: 32099531; PMCID: PMC7031935.[PubMed](external link)

  7. Kito F, Oyama R, Sakumoto M, Takahashi M, Shiozawa K, Qiao Z, Sakamoto H,Hirose T, Setsu N, Yoshida A, Kawai A, Kondo T. Establishment and characterization of novel patient-derived osteosarcoma xenograft and cell line. In Vitro Cell Dev Biol Anim. 2018 Aug;54(7):528-536. doi:10.1007/s11626-018-0274-2. Epub 2018 Jun 25. PMID: 29943355.[PumMed](external link)

  8. Kito F, Oyama R, Noguchi R, Hattori E, Sakumoto M, Endo M, Kobayashi E, Yoshida A, Kawai A, Kondo T. Establishment and characterization of novel patient-derived extraskeletal osteosarcoma cell line NCC-ESOS1-C1. Hum Cell. 2020 Jan;33(1):283-290. doi: 10.1007/s13577-019-00291-z. Epub 2019 Oct 17. PMID:31625124.In Vitro Cell Dev Biol Anim (2018) 54,770-778. [PubMed](external link)

  9. Sakumoto M, Oyama R, Takahashi M, Takai Y, Kito F, Shiozawa K, Qiao Z, Endo M, Yoshida A, Kawai A, Kondo T. Establishment and proteomic characterization of patient-derived clear cell sarcoma xenografts and cell lines. In Vitro Cell Dev Biol Anim. 2018 Feb;54(2):163-176. doi: 10.1007/s11626-017-0207-5. Epub 2017 Dec 1. PMID: 29197033.[PubMed](external link)

  10.  Oyama R, Takahashi M, Yoshida A, Sakumoto M, Takai Y, Kito F, Shiozawa K, Qiao Z, Arai Y, Shibata T, Araki Y, Endo M, Kawai A, Kondo T. Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines. Sci Rep. 2017 Jul 5;7(1):4712. doi: 10.1038/s41598-017-04967-0. PMID: 28680140; PMCID:PMC5498486. [PumMed](external link)
  11. Yoshimatsu Y, Noguchi R, Tsuchiya R, Kito F, Sei A, Sugaya J, Nakagawa M,Yoshida A, Iwata S, Kawai A, Kondo T. Establishment and characterization of NCC-CDS2-C1: a novel patient-derived cell line of CIC-DUX4 sarcoma. Hum Cell. 2020 Apr;33(2):427-436. doi: 10.1007/s13577-019-00312-x. Epub 2020 Jan 2. PMID:31898195.Human Cell (2019). [PubMed](external link)

  12. Tiss. Cult. Res. Commun. (2018) 37,147-158.  [J-Stage](external link
  13. Yoshimatsu Y, Noguchi R, Tsuchiya R, Sei A, Sugaya J, Iwata S, Sugiyama M,Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-ssRMS1-C1: a novel patient-derived spindle-cell/sclerosing rhabdomyosarcoma cell line. Hum Cell. 2020 Apr 16. doi: 10.1007/s13577-020-00359-1. Epub ahead of print. PMID: 32300959.[PubMed](external link)

  14. Kito F, Oyama R, Takai Y, Sakumoto M, Shiozawa K, Qiao Z, Uehara T, Yoshida A, Kawai A, Kondo T. Establishment and characterization of the NCC-SS1-C1 synovial sarcoma cell line. Hum Cell. 2018 Apr;31(2):167-174. doi:10.1007/s13577-018-0199-9. Epub 2018 Feb 15. PMID: 29450702.[PubMed](external link)

  15. Oyama R, Kito F, Sakumoto M, Shiozawa K, Toki S, Endo M, Yoshida A, Kawai A, Kondo T. Establishment and proteomic characterization of a novel synovial sarcoma cell line, NCC-SS2-C1. In Vitro Cell Dev Biol Anim. 2018 May;54(5):392-399. doi: 10.1007/s11626-018-0237-7. Epub 2018 Apr 6. PMID:29626278.[PubMed](external link)

  16. Yoshimatsu Y, Noguchi R, Tsuchiya R, Sei A, Sugaya J, Iwata S, Yoshida A,Kawai A, Kondo T. Establishment and Characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma. Hum Cell. 2020 Apr 9. doi:10.1007/s13577-020-00354-6. Epub ahead of print. PMID: 32274656.[PubMed](external link)

  17. Oyama R, Kito F, Qiao Z, Sakumoto M, Shiozawa K, Toki S, Yoshida A, Kawai A, Kondo T. Establishment of novel atient-derived models of dermatofibrosarcoma protuberans: two cell lines, NCC-DFSP1-C1 and NCC-DFSP2-C1. In Vitro Cell Dev Biol Anim. 2019 Jan;55(1):62-73. doi: 10.1007/s11626-018-0305-z. Epub 2018 Nov 8. PMID: 30411273.[PubMed](external link)

  18. Yoshimatsu Y, Noguchi R, Tsuchiya R, Sei A, Nakagawa M, Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-DFSP3-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line. Hum Cell. 2020 Apr 30. doi:10.1007/s13577-020-00365-3. Epub ahead of print. PMID: 32356243.[PubMed](external link)

  19. Kito F, Oyama R, Sakumoto M, Shiozawa K, Qiao Z, Toki S, Yoshida A, Kawai A, Kondo T. Establishment and Characterization of a novel cell line, NCC-MFS1-C1, derived from a patient with myxofibrosarcoma. Hum Cell. 2019 Apr;32(2):214-222.doi: 10.1007/s13577-018-00233-1. Epub 2019 Feb 8. PMID: 30737712.[PubMed](external link)

  20. Oyama R, Kito F, Qiao Z, Sakumoto M, Noguchi R, Takahashi M, Toki S, Tanzawa Y, Yoshida A, Kawai A, Kondo T. Establishment of a novel patient-derived Ewing's sarcoma cell line, NCC-ES1-C1. In Vitro Cell Dev Biol Anim. 2018 Dec;54(10):770-778. doi: 10.1007/s11626-018-0302-2. Epub 2018 Oct 15. PMID:30324244. [PubMed](external link)

  21. Oyama R, Kito F, Takahashi M, Sakumoto M, Shiozawa K, Qiao Z, Noguchi R,Kubo T, Toki S, Nakatani F, Yoshida A, Kawai A, Kondo T. Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1. Hum Cell. 2019 Apr;32(2):202-213. doi: 10.1007/s13577-018-0232-2. Epub 2019 Feb 8. PMID: 30737713.[PubMed](external link)