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業績

  1. Kumazaki M, Shimomura I, Kiyono T, Ochiya T, and Yamamoto Y: Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells. Biochem Biophys Res Commun 525:483-490, 2020.
  2. Heawchaiyaphum C, Iizasa H, Ekalaksananan T, Burassakarn A, Kiyono T, Kanehiro Y, Yoshiyama H, and Pientong C: Epstein-Barr Virus Infection of Oral Squamous Cells. Microorganisms 8, 2020.
  3. Orimoto A, Katayama M, Tani T, Ito K, Eitsuka T, Nakagawa K, Inoue-Murayama M, Onuma M, Kiyono T, and Fukuda T: Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1. Biochem Biophys Res Commun, 2020.
  4. Orimoto A, Kyakumoto S, Eitsuka T, Nakagawa K, Kiyono T, and Fukuda T: Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition. PloS one 15:e0229996, 2020.
  5. Morris T A, Naik J, Fibben K S, Kong X, Kiyono T, Yokomori K, and Grosberg A: Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs. PLoS Comput Biol 16:e1007676, 2020.
  6. Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak T W, Nakao K, Nakagawa T, Maehama T, and Suzuki A: YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv 6:eaay3324, 2020.
  7. Yang X Y, Ozawa S, Kato Y, Maehata Y, Izukuri K, Ikoma T, Kanamori K, Akasaka T, Suzuki K, Iwabuchi H, Kurata S I, Katoh I, Sakurai T, Kiyono T, and Hata R I: C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression. Int J Mol Sci 20, 2019.
  8. Tani T, Eitsuka T, Katayama M, Nagamine T, Nakaya Y, Suzuki H, Kiyono T, Nakagawa K, Inoue-Murayama M, Onuma M, and Fukuda T: Establishment of immortalized primary cell from the critically endangered Bonin flying fox (Pteropus pselaphon). PloS one 14:e0221364, 2019.
  9. Sekine S, Kiyono T, Ryo E, Ogawa R, Wakai S, Ichikawa H, Suzuki K, Arai S, Tsuta K, Ishida M, Sasajima Y, Goshima N, Yamazaki N, and Mori T: Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. J Clin Invest 130:3827-3832, 2019.
  10. Naito Y, Yamamoto Y, Sakamoto N, Shimomura I, Kogure A, Kumazaki M, Yokoi A, Yashiro M, Kiyono T, Yanagihara K, Takahashi R U, Hirakawa K, Yasui W, and Ochiya T: Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts. Oncogene 38:5566-5579, 2019.
  11. Murakami I, Egawa N, Griffin H, Yin W, Kranjec C, Nakahara T, Kiyono T, and Doorbar J: Roles for E1-independent replication and E6-mediated p53 degradation during low-risk and high-risk human papillomavirus genome maintenance. PLoS Pathog 15:e1007755, 2019.
  12. Katayama M, Kiyono T, Ohmaki H, Eitsuka T, Endoh D, Inoue-Murayama M, Nakajima N, Onuma M, and Fukuda T: Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators. J Cell Physiol 234:6709-6720, 2019.
  13. Katayama M, Kiyono T, Kuroda K, Ueda K, Onuma M, Shirakawa H, and Fukuda T: Rat-derived feeder cells immortalized by expression of mutant CDK4, cyclin D, and telomerase can support stem cell growth. Biochim Biophys Acta Mol Cell Res 1866:945-956, 2019.
  14. Inoue M, Kajiwara K, Yamaguchi A, Kiyono T, Samura O, Akutsu H, Sago H, Okamoto A, and Umezawa A: Autonomous trisomic rescue of Down syndrome cells. Lab Invest, 2019.
  15. Hirose Y, Onuki M, Tenjimbayashi Y, Yamaguchi-Naka M, Mori S, Tasaka N, Satoh T, Morisada T, Iwata T, Kiyono T, Mimura T, Sekizawa A, Matsumoto K, and Kukimoto I: Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions. Viruses 11, 2019.
  16. Ghani F I, Dendo K, Watanabe R, Yamada K, Yoshimatsu Y, Yugawa T, Nakahara T, Tanaka K, Yoshida H, Yoshida M, Ishikawa M, Goshima N, Kato T, and Kiyono T: An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors. Cells 8, 2019.
  17. Fukuda T, Gouko R, Eitsuka T, Suzuki R, Takahashi K, Nakagawa K, Sugano E, Tomita H, and Kiyono T: Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. Front Genet 10:587, 2019.
  18. Yoshida M, Taguchi A, Kawana K, Ogishima J, Adachi K, Kawata A, Nakamura H, Sato M, Fujimoto A, Inoue T, Tomio K, Mori M, Nagamatsu T, Arimoto T, Koga K, Hiraike O W, Oda K, Kiyono T, Osuga Y, and Fujii T: Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity. Int J Oncol 53:1580-1590, 2018.
  19. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan M M, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, and Muramatsu M: Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Scientific reports 8:9745, 2018.
  20. Nakamura K, Nakayama K, Ishikawa N, Ishikawa M, Sultana R, Kiyono T, and Kyo S: Reconstitution of high-grade serous ovarian carcinoma from primary fallopian tube secretory epithelial cells. Oncotarget 9:12609-12619, 2018.
  21. Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, Tanaka T, Nishimura Y, Mizoguchi A, Goshima N, and Inagaki M: EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Nature communications 9:758, 2018.
  22. Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, Inagaki M, and Hayashi Y: Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Genes Cells 23:1023-1042, 2018.
  23. Gouko R, Onuma M, Eitsuka T, Katayama M, Takahashi K, Nakagawa K, Inoue-Murayama M, Kiyono T, and Fukuda T: Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. Cytotechnology 70:1619-1630, 2018.
  24. Fukuda T, Eitsuka T, Donai K, Kurita M, Saito T, Okamoto H, Kinoshita K, Katayama M, Nitto H, Uchida T, Onuma M, Sone H, Inoue-Murayama M, and Kiyono T: Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta). Scientific reports 8:9229, 2018.
  25. Dendo K, Yugawa T, Nakahara T, Ohno S I, Goshima N, Arakawa H, and Kiyono T: Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression. Carcinogenesis 39:202-213, 2018.
  26. Nagata Y, Kiyono T, Okamura K, Goto Y I, Matsuo M, Ikemoto-Uezumi M, and Hashimoto N: Interleukin-1beta (IL-1beta)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1beta on human dystrophic myogenic cells. PloS one 12:e0188821, 2017.
  27. Mori S, Takeuchi T, Ishii Y, Yugawa T, Kiyono T, Nishina H, and Kukimoto I: Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J Virol 91, 2017.
  28. Yamamoto E, Niimi K, Kiyono T, Yamamoto T, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, and Kikkawa F: Establishment and characterization of cell lines derived from complete hydatidiform mole. Int J Mol Med 40:614-622, 2017.
  29. Kayama K, Watanabe S, Takafuji T, Tsuji T, Hironaka K, Matsumoto M, Nakayama K I, Enari M, Kohno T, Shiraishi K, Kiyono T, Yoshida K, Sugimoto N, and Fujita M: GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. EMBO reports 18:123-137, 2017.
  30. Katayama M, Hirayama T, Kiyono T, Onuma M, Tani T, Takeda S, Nishimori K, and Fukuda T: Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. J Reprod Dev 63:311-318, 2017.
  31. Hashimoto N, Kiyono T, Saitow F, Asada M, and Yoshida M: Reversible differentiation of immortalized human bladder smooth muscle cells accompanied by actin bundle reorganization. PloS one 12:e0186584, 2017.
  32. Hashimoto H, Suda Y, Miyashita T, Ochiai A, Tsuboi M, Masutomi K, Kiyono T, and Ishii G: A novel method to generate single-cell-derived cancer-associated fibroblast clones. J Cancer Res Clin Oncol 143:1409-1419, 2017.
  33. Fuchigami T, Koyama H, Kishida M, Nishizawa Y, Iijima M, Kibe T, Ueda M, Kiyono T, Maniwa Y, Nakamura N, and Kishida S: Fibroblasts promote the collective invasion of ameloblastoma tumor cells in a 3D coculture model. FEBS Open Bio 7:2000-2007, 2017.
  34. Yoshimatsu Y, Nakahara T, Tanaka K, Inagawa Y, Narisawa-Saito M, Yugawa T, Ohno S I, Fujita M, Nakagama H, and Kiyono T: Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes. Cancer Sci 108:1303-1309, 2017.
  35. Yokoi A, Yoshioka Y, Yamamoto Y, Ishikawa M, Ikeda S I, Kato T, Kiyono T, Takeshita F, Kajiyama H, Kikkawa F, and Ochiya T: Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nature communications 8:14470, 2017.
  36. Shinohara M, Sumino Y, Sato F, Kiyono T, Hashimoto N, and Mimata H: Tumor necrosis factor-alpha inhibits differentiation of myogenic cells in human urethral rhabdosphincter. Int J Urol 24:461-467, 2017.
  37. Noguchi K, Wakai K, Kiyono T, Kawabe M, Yoshikawa K, Hashimoto-Tamaoki T, Kishimoto H, and Nakano Y: Molecular analysis of keratocystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients. Int J Oncol 51:1731-1738, 2017.
  38. Nakahara T, and Kiyono T: Interplay between NF-κB/interferon signaling and the genome replication of HPV. Future Virology 11:141-155, 2016.
  39. Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya M A, Asano R, Tokinaga A, Kiyono T, Hirahara F, Ohno S, and Miyagi E: Aberrant Expression of the Cell Polarity Regulator aPKClambda/iota is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 35:106-117, 2016.
  40. Kondo T, Ozawa S, Ikoma T, Yang X Y, Kanamori K, Suzuki K, Iwabuchi H, Maehata Y, Miyamoto C, Taguchi T, Kiyono T, Kubota E, and Hata R I: Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma. Oncogenesis 5:e240, 2016.
  41. Kinebuchi M, Matsuura A, Kiyono T, Nomura Y, and Kimura S: Diagnostic copper imaging of Menkes disease by synchrotron radiation-generated X-ray fluorescence analysis. Scientific reports 6:33247, 2016.
  42. Yoshida M, Taguchi A, Kawana K, Adachi K, Kawata A, Ogishima J, Nakamura H, Fujimoto A, Sato M, Inoue T, Nishida H, Furuya H, Tomio K, Arimoto T, Koga K, Wada-Hiraike O, Oda K, Nagamatsu T, Kiyono T, Osuga Y, and Fujii T: Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis. PloS one 11:e0160330, 2016.
  43. Katayama M, Hirayama T, Horie K, Kiyono T, Donai K, Takeda S, Nishimori K, and Fukuda T: Induced Pluripotent Stem Cells With Six Reprogramming Factors From Prairie Vole, Which Is an Animal Model for Social Behaviors. Cell Transplant 25:783-796, 2016.
  44. Kanda T, Furuse Y, Oshitani H, and Kiyono T: Highly Efficient CRISPR/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains. J Virol 90:4383-4393, 2016.
  45. Kakiuchi T, Takahara T, Kasugai Y, Arita K, Yoshida N, Karube K, Suguro M, Matsuo K, Nakanishi H, Kiyono T, Nakamura S, Osada H, Sekido Y, Seto M, and Tsuzuki S: Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation. Carcinogenesis, 2016.
  46. Iwata Y, Suzuki N, Ohtake H, Kamauchi S, Hashimoto N, Kiyono T, and Wakabayashi S: Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2-independent mechanisms, unlike muscular dystrophy. Journal of cachexia, sarcopenia and muscle 7:366-376, 2016.
  47. Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, and Inagaki M: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. J Cell Biol 212:409-423, 2016.
  48. Katayama M, Kiyono T, Horie K, Hirayama T, Eitsuka T, Kuroda K, Donai K, Hidema S, Nishimori K, and Fukuda T: Establishment of an immortalized cell line derived from the prairie vole via lentivirus-mediated transduction of mutant cyclin-dependent kinase 4, cyclin D, and telomerase reverse transcriptase. Experimental animals / Japanese Association for Laboratory Animal Science 65:87-96, 2016.
  49. Fukuda T, Iino Y, Eitsuka T, Onuma M, Katayama M, Murata K, Inoue-Murayama M, Hara K, Isogai E, and Kiyono T: Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators. Cytotechnology 68:1937-1947, 2016.
  50. Chopjitt P, Pientong C, Sunthamala N, Kongyingyoes B, Haonon O, Boonmars T, Kikawa S, Nakahara T, Kiyono T, and Ekalaksananan T: E6D25E, HPV16 Asian variant shows specific proteomic pattern correlating in cells transformation and suppressive innate immune response. Biochem Biophys Res Commun 478:417-423, 2016.
  51. Yachida S, Wood L D, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss M J, Wolfgang C L, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban R H, and Shibata T: Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. Cancer cell 29:229-240, 2016.
  52. Tone H, Yoshioka S, Akiyama H, Nishimura A, Ichimura M, Nakatani M, Kiyono T, Toyoda M, Watanabe M, and Umezawa A: Embryoid Body-Explant Outgrowth Cultivation from Induced Pluripotent Stem Cells in an Automated Closed Platform. BioMed research international 2016:7098987, 2016.
  53. Pantic B, Borgia D, Giunco S, Malena A, Kiyono T, Salvatori S, De Rossi A, Giardina E, Sangiuolo F, Pegoraro E, Vergani L, and Botta A: Reliable and versatile immortal muscle cell models from healthy and myotonic dystrophy type 1 primary human myoblasts. Exp Cell Res 342:39-51, 2016.
  54. Fukuda T, Iino Y, Onuma M, Gen B, Inoue-Murayama M, and Kiyono T: Expression of human cell cycle regulators in the primary cell line of the African savannah elephant (loxodonta africana) increases proliferation until senescence, but does not induce immortalization. In vitro cellular & developmental biology. Animal 52:20-26, 2016.
  55. Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, and Kiyono T: Activation of NF-kappaB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. J Virol 89:5040-5059, 2015.
  56. Kuroda K, Kiyono T, Isogai E, Masuda M, Narita M, Okuno K, Koyanagi Y, and Fukuda T: Immortalization of Fetal Bovine Colon Epithelial Cells by Expression of Human Cyclin D1, Mutant Cyclin Dependent Kinase 4, and Telomerase Reverse Transcriptase: An In Vitro Model for Bacterial Infection. PloS one 10:e0143473, 2015.
  57. Kuroda K, Kiyono T, Eitsuka T, Isogai H, Takahashi K, Donai K, Isogai E, and Fukuda T: Establishment of cell lines derived from the genus Macaca through controlled expression of cell cycle regulators. Journal of cellular biochemistry 116:205-211, 2015.
  58. Ichioka M, Mita S, Shimizu Y, Imada K, Kiyono T, Bono Y, and Kyo S: Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells. The Journal of steroid biochemistry and molecular biology 147:103-110, 2015.
  59. Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, and Taniguchi M: Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice. Scientific reports 5:9083, 2015.
  60. Takeshima H, Niwa T, Takahashi T, Wakabayashi M, Yamashita S, Ando T, Inagawa Y, Taniguchi H, Katai H, Sugiyama T, Kiyono T, and Ushijima T: Frequent involvement of chromatin remodeler alterations in gastric field cancerization. Cancer letters 357:328-338, 2015.
  61. Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, Kiyono T, Kurumizaka H, Ohkawa Y, and Fujita M: Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. Nucleic acids research 43:5898-5911, 2015.
  62. Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, Yukuhiro M, Morimoto H, Pang N, Liu B, Kiyono T, Amemiya M, Tanaka K, Yoshida K, Sugimoto N, Ohshima T, and Fujita M: A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo. Biochim Biophys Acta 1850:1676-1684, 2015.
  63. Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, and Kikkawa F: CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization. Reprod Sci 22:377-384, 2015.